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Significance of Crude and Degummed Citrullus Lanatus Seed oil on Inflammatory Cytokines in Experimental Infection Induced by Candida Albicans

This study evaluated immunomodulatory and candidacidal properties of Citrullus lanatus seed oil (CLSO) on Candida albicans-infected rat. The immunomodulatory and candidacidal activities of both crude and degummed oil at varied doses were determined using 80 female albino rats, randomised into 10 groups of 8 rats per group based on the days 7 and 14 of study. Delayed hypersensitivity reaction showed a significant increase (p<0.05) in the hind paw oedema of rats treated with crude and degummed oil after 24 hours; however after 48 hour, a significant decrease (p<0.05) in hind paw oedema was observed. However, the CD4 + T-lymphocytes decreased at day 14 when compared with day 7 counterpart. In the same vein, IFN-γ and TNF-α decreased from day 7 to day 14 of the study; while IL-10 and IgA increased from day 7 to day 14 of the study. CLSO does not boost immune system, rather demonstrated anti-inflammatory activities of the oil.

Keywords: Candidiasis; CD4 count; cytokines; degummed oil; immunosuppression.

ACTA PHARMACEUTICA SCIENCIA Dergisi 59/3. Sayısı İçin Tıklayınız.

Ekleme Tarihi: 23/03/2023 - 10:00Son Güncelleme Tarihi: 26/07/2023 - 11:51