Formulation And Characterization Of Intra Nasal Delivery Of Nortriptyline Hydrochloride Thermoreversible Gelling System In Treatment Of Depression
Depression is a common psychiatric disorder affecting about 120 million people worldwide, and statistics clearly identify it as a major public health problem.1 . Conventional oral dosage forms are available in market for treatment of depression, but the major drawbacks with these are many patients find it difficult to swallow (dysphagia) tablets and capsules. The difficulty experienced mainly in pediatrics and geriatrics patients2 . The main advantages of nose to brain delivery such as rapidly absorbed through the nasal mucosa, preventing
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