Applications of Cell Culture Studies in Pharmaceutical Technology
Studies conducted during the initial development of drugs such as toxicity, corrosion and drug activity were carried out on animals; however, in the past 10 to 20 years, alternatives have been sought due to the fact that animals do not effectively model human in vivo conditions and unexpected responses are observed in the studies. Cell culture studies made positive contributions to the initial development of drugs. Contrary to animal studies, the need for low drug and a short response time are the characteristics for in vitro cell culture methods1 . In 2005, more than 100 million animals were used and 10 billion dollars were spent for animal toxicity experiments2 . It is possible to reduce this cost and the amount of animal use for experiments with well-designed cell culture studies3 .
ACTA PHARMACEUTICA SCIENCIA Dergisi 55/3/2. Sayısı İçin Tıklayınız.