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Classifying Druggability on Potential Binding Sites of Glycogen Synthase Kinase-3β: An In-Silico Assessment

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase that exists in two highly homologous forms: GSK-3α and GSK-3β encoded by two different genes1-3. Moreover, in humans, a splice variant (GSK-3β2) has been reported4 . The role of GSK-3 as a drug target has been implicated in a variety of unmet human diseases, such as Alzheimer’s disease (AD)5–8, bipolar disorder9,10, various forms of cancers11,12, diabetes13, and many other diseases14–17.

ACTA PHARMACEUTICA SCIENCIA Dergisi 55/3/1. Sayısı İçin Tıklayınız.