Synthesis of Novel 3, 5, 6-trisubstituted triazine Derivatives and Their Biological Activity Evaluation as Potential Antitumor and Anti-inflammatory Agents
Together cardiovascular diseases, cancer is one of the common causes of death. By the discovery of mechanisms of cancer, efforts focused on different targets to treat disease. Besides the new techniques like hyperthermia, photodynamic therapy and stem cell transplation; old techniques radiotherapy, hormonal and non-hormonal chemotherapy, immunotherapy and surgery methods is still being used. In chemotherapy, alkylation agents, mitotic inhibitors and antimetabolites are used either alone or in combination with each other. In simple terms, a selective drug must be active on cancer cells but inactive in normal cells. But the differences between normal and cancer cells is quite little and not qualitative so that its hard to find an exploitable mechanism .
ACTA PHARMACEUTICA SCIENCIA Dergisi 54/8. Sayısı İçin Tıklayınız.