The aim of the course is to understand the 3D structure of proteins and make connection between the structure and the function of proteins. In addition, novel proteins can be designed with tailored functions.
Course Content
This course contains; Basic Structural Principles,Folding and Flexibility,DNA Structure,Structure, Function and Engineering,The mechanism of DNA recognition in prokaryotes and eukaryotes ,Enzyme Catalysis,Membrane Proteins,Signal Transduction,Fibrous Proteins,The mechanism of recognition of foreign molecules by immune system,The Structure of Spherical Viruses,The principles of prediction, Engineering and Design of Protein Structures,Determination of Protein Structures,Special Topics.
Dersin Öğrenme Kazanımları
Teaching Methods
Assessment Methods
Capable of building the relation between protein structure and function
10, 12, 14, 16, 19, 9
A, E, F
Proteins can be designed with novel functions.
10, 12, 14, 16, 19, 5, 9
A, E, F
The impact of environment on the enzyme kinetics can be interpreted.
10, 16, 19, 20
A, E, F
Capable of interpretation of the results obtained from molecular dynamics simulations in terms of protein structure-function relationship.
A: Traditional Written Exam, E: Homework, F: Project Task
Course Outline
Order
Subjects
Preliminary Work
1
Basic Structural Principles
2
Folding and Flexibility
3
DNA Structure
4
Structure, Function and Engineering
5
The mechanism of DNA recognition in prokaryotes and eukaryotes
6
Enzyme Catalysis
7
Membrane Proteins
8
Signal Transduction
9
Fibrous Proteins
10
The mechanism of recognition of foreign molecules by immune system
11
The Structure of Spherical Viruses
12
The principles of prediction, Engineering and Design of Protein Structures
13
Determination of Protein Structures
14
Special Topics
Resources
Introduction to Protein Structure, 2 nd Edition, Carl Brendon and John Tooze
Course Contribution to Program Qualifications
Course Contribution to Program Qualifications
No
Program Qualification
Contribution Level
1
2
3
4
5
1
An ability to apply knowledge of mathematics, science, and engineering
X
2
An ability to identify, formulate, and solve engineering problems
X
3
An ability to design a system, component, or process to meet desired needs within realistic constraints such as economic, environmental, social, political, ethical, health and safety, manufacturability, and sustainability
X
4
An ability to use the techniques, skills, and modern engineering tools necessary for engineering practice
X
5
An ability to use the techniques, skills, and modern engineering tools necessary for engineering practice
X
6
An ability to function on multidisciplinary teams
X
7
An ability to communicate effectively
X
8
A recognition of the need for, and an ability to engage in life-long learning
X
9
An understanding of professional and ethical responsibility
X
10
A knowledge of contemporary issues
X
11
The broad education necessary to understand the impact of engineering solutions in a global, economic, environmental, and societal context
X
12
Capability to apply and decide on engineering principals while understanding and rehabilitating the human body
X
Assessment Methods
Contribution Level
Absolute Evaluation
Rate of Midterm Exam to Success
30
Rate of Final Exam to Success
70
Total
100
ECTS / Workload Table
Activities
Number of
Duration(Hour)
Total Workload(Hour)
Course Hours
14
3
42
Guided Problem Solving
0
0
0
Resolution of Homework Problems and Submission as a Report
1
40
40
Term Project
0
0
0
Presentation of Project / Seminar
1
20
20
Quiz
0
0
0
Midterm Exam
1
30
30
General Exam
1
40
40
Performance Task, Maintenance Plan
0
0
0
Total Workload(Hour)
172
Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(172/30)
6
ECTS of the course: 30 hours of work is counted as 1 ECTS credit.
Detail Informations of the Course
Course Description
Course
Code
Semester
T+P (Hour)
Credit
ECTS
PROTEIN: STRUCTURE and FUNCTION
-
Fall Semester
3+0
3
6
Course Program
Prerequisites Courses
Recommended Elective Courses
Language of Course
English
Course Level
First Cycle (Bachelor's Degree)
Course Type
Elective
Course Coordinator
Assoc.Prof. Özge ŞENSOY
Name of Lecturer(s)
Assoc.Prof. Özge ŞENSOY
Assistant(s)
Aim
The aim of the course is to understand the 3D structure of proteins and make connection between the structure and the function of proteins. In addition, novel proteins can be designed with tailored functions.
Course Content
This course contains; Basic Structural Principles,Folding and Flexibility,DNA Structure,Structure, Function and Engineering,The mechanism of DNA recognition in prokaryotes and eukaryotes ,Enzyme Catalysis,Membrane Proteins,Signal Transduction,Fibrous Proteins,The mechanism of recognition of foreign molecules by immune system,The Structure of Spherical Viruses,The principles of prediction, Engineering and Design of Protein Structures,Determination of Protein Structures,Special Topics.
Dersin Öğrenme Kazanımları
Teaching Methods
Assessment Methods
Capable of building the relation between protein structure and function
10, 12, 14, 16, 19, 9
A, E, F
Proteins can be designed with novel functions.
10, 12, 14, 16, 19, 5, 9
A, E, F
The impact of environment on the enzyme kinetics can be interpreted.
10, 16, 19, 20
A, E, F
Capable of interpretation of the results obtained from molecular dynamics simulations in terms of protein structure-function relationship.
A: Traditional Written Exam, E: Homework, F: Project Task
Course Outline
Order
Subjects
Preliminary Work
1
Basic Structural Principles
2
Folding and Flexibility
3
DNA Structure
4
Structure, Function and Engineering
5
The mechanism of DNA recognition in prokaryotes and eukaryotes
6
Enzyme Catalysis
7
Membrane Proteins
8
Signal Transduction
9
Fibrous Proteins
10
The mechanism of recognition of foreign molecules by immune system
11
The Structure of Spherical Viruses
12
The principles of prediction, Engineering and Design of Protein Structures
13
Determination of Protein Structures
14
Special Topics
Resources
Introduction to Protein Structure, 2 nd Edition, Carl Brendon and John Tooze
Course Contribution to Program Qualifications
Course Contribution to Program Qualifications
No
Program Qualification
Contribution Level
1
2
3
4
5
1
An ability to apply knowledge of mathematics, science, and engineering
X
2
An ability to identify, formulate, and solve engineering problems
X
3
An ability to design a system, component, or process to meet desired needs within realistic constraints such as economic, environmental, social, political, ethical, health and safety, manufacturability, and sustainability
X
4
An ability to use the techniques, skills, and modern engineering tools necessary for engineering practice
X
5
An ability to use the techniques, skills, and modern engineering tools necessary for engineering practice
X
6
An ability to function on multidisciplinary teams
X
7
An ability to communicate effectively
X
8
A recognition of the need for, and an ability to engage in life-long learning
X
9
An understanding of professional and ethical responsibility
X
10
A knowledge of contemporary issues
X
11
The broad education necessary to understand the impact of engineering solutions in a global, economic, environmental, and societal context
X
12
Capability to apply and decide on engineering principals while understanding and rehabilitating the human body
