The aim of this course is to understand the molecular mechanisms at the nervous system level and to examine the effects of these mechanisms on neuronal functions. In addition to understanding the interactions between nerve cells and synapse formation at the cellular level, it is also aimed to learn the mechanisms of neuroplasticity, learning processes and various neurodegenerative diseases.
Course Content
This course contains; Introduction to Brain and Behavior,Nerve Cells, Neural Circutry and Behavior,Genes and Behavior,Cells of the Nervous System,Effects of Glial Cells to Neural Function,Midterm,Ion Channels - 1,Ion Channels - 2,Membrane Potential -1,Membrane Potential -2,Passive Electircal Properties of the Neuron,The Action Potential – 1,The Action Potential – 2,Synaptic transmission.
Dersin Öğrenme Kazanımları
Teaching Methods
Assessment Methods
4.Can analyse the Action Potential (Analysis).
1. Can categorize the cells of the nervous system (Analysis).
1.1. Defines the parts of a nevre cell (knowledge).
1.2. Defines the organelles of a nevre cell (knowledge).
1.3. Summarizes the cells of supporting tissue (comprehension).
1.4. Explains the functioning of the nervous system using the properties of the nerve cell (comprehension).
2. Can distinguish ion channels (Analysis).
2.1. Explains the contribution of ion channels to fast transmit in nervous system (comprehension).
2.2. Lists several characteristics of ion channels shared by all cells (knowledge).
2.3. Explains recording currents from a single ion channel (comprehension).
2.4. Composes biophysical, biochemical and molecular techniques used to understand the structure of ion channels. (synthesis).
3. Can analyse Membrane potential and the passive electrical properties of the neuron (Analysis).
3.1. Interprets the effect of nongated and gated ion channels to the resting membrane potential (application).
3.2. Calculates the contributions of different ions to the resting membrane potential via Goldman Equation (analysis).
3.3. Constructs the functional properties of the nevre cell as an electrical equivalent circuit (synthesis).
3.4. Explains the effect of the passive electrical properties of the neuron to electrical signaling (comprehension).
4.1. Defines the voltage-gated channels (knowledge).
4.2. Interprets the effect of variations in voltage-gated ion channels on signaling capabilities of neurons (application).
4.3. Defines voltage-clamp and patch-clamp techniques (knowledge)
Teaching Methods:
Assessment Methods:
Course Outline
Order
Subjects
Preliminary Work
1
Introduction to Brain and Behavior
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 5-17
2
Nerve Cells, Neural Circutry and Behavior
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 21-37
3
Genes and Behavior
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 39-59
4
Cells of the Nervous System
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 71-87
5
Effects of Glial Cells to Neural Function
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 87-96
6
Midterm
7
Ion Channels - 1
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 100-110
8
Ion Channels - 2
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 110-124
9
Membrane Potential -1
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 126-134
10
Membrane Potential -2
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 134-147
11
Passive Electircal Properties of the Neuron
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 134-147
12
The Action Potential – 1
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 148-170
13
The Action Potential – 2
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 148-170
14
Synaptic transmission
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 177-187
Resources
Principles of Neural Science - Fifth Edition (Eric R. Kandel)
Digital resources, online courses, articles, web-based simulations, seminars and conferences
Course Contribution to Program Qualifications
Course Contribution to Program Qualifications
No
Program Qualification
Contribution Level
1
2
3
4
5
1
Has the essential knowledge about the structure and functioning of the nervous system.
X
2
Knows the essential scientific questions and current research topics in neuroscience and produces hypotheses about them.
X
3
Have knowledge and interpretation skills about neurodegenerative processes.
X
4
Know the principles of technologies for the measurement of molecular and cellular level parameters.
X
5
Defines the methods used in neuroscience researches. In own research area uses the required techniques without assistance, develops new methods and techniques. Designs research projects and submits them as proposals. Presents the research findings in oral or written forms and in scientific articles.
X
6
Uses the communication and computer technology effectively in theoretical and practical studies.
X
7
Able to present theoretical or research data orally or written in Turkish as well in English languages.
X
8
Adheres to ethical values and behaves according to dynamics of social responsibility.
X
9
While focusing on the basic research behaves in accordance with the principle that neuroscience research should eventually aim clinical implications and benefit.
X
10
Designs and conducts scientific research, independently and within a team. Manages a research lab and establishes new ones.
X
11
Evaluates all new information regarding the field and associate them based on available knowledge.
X
Assessment Methods
Contribution Level
Absolute Evaluation
Rate of Midterm Exam to Success
50
Rate of Final Exam to Success
50
Total
100
ECTS / Workload Table
Activities
Number of
Duration(Hour)
Total Workload(Hour)
Course Hours
14
3
42
Guided Problem Solving
14
6
84
Resolution of Homework Problems and Submission as a Report
0
0
0
Term Project
0
0
0
Presentation of Project / Seminar
0
0
0
Quiz
0
0
0
Midterm Exam
1
18
18
General Exam
1
36
36
Performance Task, Maintenance Plan
0
0
0
Total Workload(Hour)
180
Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(180/30)
6
ECTS of the course: 30 hours of work is counted as 1 ECTS credit.
The aim of this course is to understand the molecular mechanisms at the nervous system level and to examine the effects of these mechanisms on neuronal functions. In addition to understanding the interactions between nerve cells and synapse formation at the cellular level, it is also aimed to learn the mechanisms of neuroplasticity, learning processes and various neurodegenerative diseases.
Course Content
This course contains; Introduction to Brain and Behavior,Nerve Cells, Neural Circutry and Behavior,Genes and Behavior,Cells of the Nervous System,Effects of Glial Cells to Neural Function,Midterm,Ion Channels - 1,Ion Channels - 2,Membrane Potential -1,Membrane Potential -2,Passive Electircal Properties of the Neuron,The Action Potential – 1,The Action Potential – 2,Synaptic transmission.
Dersin Öğrenme Kazanımları
Teaching Methods
Assessment Methods
4.Can analyse the Action Potential (Analysis).
1. Can categorize the cells of the nervous system (Analysis).
1.1. Defines the parts of a nevre cell (knowledge).
1.2. Defines the organelles of a nevre cell (knowledge).
1.3. Summarizes the cells of supporting tissue (comprehension).
1.4. Explains the functioning of the nervous system using the properties of the nerve cell (comprehension).
2. Can distinguish ion channels (Analysis).
2.1. Explains the contribution of ion channels to fast transmit in nervous system (comprehension).
2.2. Lists several characteristics of ion channels shared by all cells (knowledge).
2.3. Explains recording currents from a single ion channel (comprehension).
2.4. Composes biophysical, biochemical and molecular techniques used to understand the structure of ion channels. (synthesis).
3. Can analyse Membrane potential and the passive electrical properties of the neuron (Analysis).
3.1. Interprets the effect of nongated and gated ion channels to the resting membrane potential (application).
3.2. Calculates the contributions of different ions to the resting membrane potential via Goldman Equation (analysis).
3.3. Constructs the functional properties of the nevre cell as an electrical equivalent circuit (synthesis).
3.4. Explains the effect of the passive electrical properties of the neuron to electrical signaling (comprehension).
4.1. Defines the voltage-gated channels (knowledge).
4.2. Interprets the effect of variations in voltage-gated ion channels on signaling capabilities of neurons (application).
4.3. Defines voltage-clamp and patch-clamp techniques (knowledge)
Teaching Methods:
Assessment Methods:
Course Outline
Order
Subjects
Preliminary Work
1
Introduction to Brain and Behavior
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 5-17
2
Nerve Cells, Neural Circutry and Behavior
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 21-37
3
Genes and Behavior
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 39-59
4
Cells of the Nervous System
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 71-87
5
Effects of Glial Cells to Neural Function
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 87-96
6
Midterm
7
Ion Channels - 1
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 100-110
8
Ion Channels - 2
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 110-124
9
Membrane Potential -1
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 126-134
10
Membrane Potential -2
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 134-147
11
Passive Electircal Properties of the Neuron
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 134-147
12
The Action Potential – 1
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 148-170
13
The Action Potential – 2
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 148-170
14
Synaptic transmission
Principles of Neural Science - Fifth Edition (Eric R. Kandel) Page: 177-187
Resources
Principles of Neural Science - Fifth Edition (Eric R. Kandel)
Digital resources, online courses, articles, web-based simulations, seminars and conferences
Course Contribution to Program Qualifications
Course Contribution to Program Qualifications
No
Program Qualification
Contribution Level
1
2
3
4
5
1
Has the essential knowledge about the structure and functioning of the nervous system.
X
2
Knows the essential scientific questions and current research topics in neuroscience and produces hypotheses about them.
X
3
Have knowledge and interpretation skills about neurodegenerative processes.
X
4
Know the principles of technologies for the measurement of molecular and cellular level parameters.
X
5
Defines the methods used in neuroscience researches. In own research area uses the required techniques without assistance, develops new methods and techniques. Designs research projects and submits them as proposals. Presents the research findings in oral or written forms and in scientific articles.
X
6
Uses the communication and computer technology effectively in theoretical and practical studies.
X
7
Able to present theoretical or research data orally or written in Turkish as well in English languages.
X
8
Adheres to ethical values and behaves according to dynamics of social responsibility.
X
9
While focusing on the basic research behaves in accordance with the principle that neuroscience research should eventually aim clinical implications and benefit.
X
10
Designs and conducts scientific research, independently and within a team. Manages a research lab and establishes new ones.
X
11
Evaluates all new information regarding the field and associate them based on available knowledge.
