Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| MEDICAL BIOLOGY & GENETICS | - | Yearly | 44+10 | - | 4 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | English |
| Course Level | First Cycle (Bachelor's Degree) |
| Course Type | Committee Course |
| Course Coordinator | Prof.Dr. Esra ÇAĞAVİ |
| Name of Lecturer(s) | Assist.Prof. İlyas ÖZÇİÇEK, Assist.Prof. Neşe AYŞİT, Prof.Dr. Esra ÇAĞAVİ, Prof.Dr. Kürşat ÖZDİLLİ, Assist.Prof. Elif Zeynep YILMAZ, Assoc.Prof. Nihal KARAKAŞ, Assist.Prof. Sven Pierre L. VILAIN, Assist.Prof. Salih GENCER, Assist.Prof. Berrak ÇAĞLAYAN |
| Assistant(s) | Prof.Dr. Esra ÇAĞAVİ, Prof.Dr. Kürşat ÖZDİLLİ, Dr.Öğr.Üye. İlyas ÖZÇİÇEK, Dr.Öğr.Üye. Neşe AYŞİT, Dr.Öğr.Üye. Elif Zeynep YILMAZ |
| Aim | The aim of this course is to define the fundamental concepts in cellular, molecular and functional aspects of medical biology and genetics of the cell, to evaluate association of pathologies and homeostasis with molecular mechanisms that will lay the foundation for understanding of basic cellular mechanisms for clinical applications that meets the requirements for medical proficiency and learning objectives. |
| Course Content | This course contains; Fundamentals of Life: The cell and biosynthesis,Proteins: Structure and function ,Lab-1: The laboratory guidelines, micropipette practice, practice in SDS-PAGE ,The genetic material of a cell: DNA, chromosomes and the genome,DNA replication, repair and recombination,RNA structure and function, transciption,Genetic code and translation,The control of gene expression and genetic switches,Epigenetics and cell memory,Lab-2: Polimerase Chain Reaction (PCR),Lab-3: DNA restriction digestion and Agarose gel electrophoresis,The structural properties and function of cell membrane,Intracellular compartments: Organelles I,Intracellular compartments: Organelles-II,Protein sorting and vesicular trafficking in the cell,Endocytosis, exocytosis and membrane transport,Cellular communication and signaling pathways-I,Cellular communication and signaling pathways-II,Cytoskeleton and motor proteins,Lab-4: Florescence Microscopy: Immunocytochemical observation of the cell ,Cellular junctions, cell adhesion and extracellular matrix,Cell Cycle ,Cell senescence and Cell death,Stem Cells and Regeneration,Cancer biology and the molecular basis of cancer,The current therapeutic approaches for cancer,Lab-5: Cell culture applications,The fundamentals of medical genetics,Mendelian Inheritance,Non-mendelian Inheritance ,Autosomal Chromosomal Disorders,Inheritance of Sex Chromosome Disorders ,Prenatal tests and Genetic Counseling. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| Define basic knowledge and concepts in molecular biology and genetics | 14, 9 | C, E |
| Define structure, function, biosynthesis and catabolic mechanisms of macromolecules in the cell | 14, 9 | C, E |
| Explains molecular biology techniques used in the study of molecules and structures that enable the cell to function. | 13, 17, 9 | C, E, G |
| Interpret the cellular processes and the cellular signaling mechanisms | 13, 14, 19, 9 | C, E |
| Define the structure and function of intracellular compartments (organelles) and associated with major organelle pathologies | 14, 9 | C |
| Defnes the basic mechanisms of embryonic development and adult tissue renewal and stem cells, as well as cell death and cell cycle control. | 14, 9 | C, E |
| Discuss the genetic basis of diseases | 10, 13, 14, 9 | C, E |
| Defines the basic molecular principles of cancer | 14, 9 | C, E |
| Explains medical genetics concepts, classification of genetic diseases, basic hereditary disease groups and inheritance principles. | 13, 14, 9 | C |
| Defines basic laboratory rules and practices in the field of medical biology. | 12, 13, 14, 17, 9 | C, E, G |
| Teaching Methods: | 10: Discussion Method, 12: Problem Solving Method, 13: Case Study Method, 14: Self Study Method, 17: Experimental Technique, 19: Brainstorming Technique, 9: Lecture Method |
| Assessment Methods: | C: Multiple-Choice Exam, E: Homework, G: Quiz |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Fundamentals of Life: The cell and biosynthesis | |
| 2 | Proteins: Structure and function | |
| 3 | Lab-1: The laboratory guidelines, micropipette practice, practice in SDS-PAGE | |
| 4 | The genetic material of a cell: DNA, chromosomes and the genome | |
| 5 | DNA replication, repair and recombination | |
| 6 | RNA structure and function, transciption | |
| 7 | Genetic code and translation | |
| 8 | The control of gene expression and genetic switches | |
| 9 | Epigenetics and cell memory | |
| 10 | Lab-2: Polimerase Chain Reaction (PCR) | |
| 11 | Lab-3: DNA restriction digestion and Agarose gel electrophoresis | |
| 12 | The structural properties and function of cell membrane | |
| 13 | Intracellular compartments: Organelles I | |
| 14 | Intracellular compartments: Organelles-II | |
| 15 | Protein sorting and vesicular trafficking in the cell | |
| 16 | Endocytosis, exocytosis and membrane transport | |
| 17 | Cellular communication and signaling pathways-I | |
| 18 | Cellular communication and signaling pathways-II | |
| 19 | Cytoskeleton and motor proteins | |
| 20 | Lab-4: Florescence Microscopy: Immunocytochemical observation of the cell | |
| 21 | Cellular junctions, cell adhesion and extracellular matrix | |
| 22 | Cell Cycle | |
| 23 | Cell senescence and Cell death | |
| 24 | Stem Cells and Regeneration | |
| 25 | Cancer biology and the molecular basis of cancer | |
| 26 | The current therapeutic approaches for cancer | |
| 27 | Lab-5: Cell culture applications | |
| 28 | The fundamentals of medical genetics | |
| 29 | Mendelian Inheritance | |
| 30 | Non-mendelian Inheritance | |
| 31 | Autosomal Chromosomal Disorders | |
| 32 | Inheritance of Sex Chromosome Disorders | |
| 33 | Prenatal tests and Genetic Counseling |
| Resources |
| 1. Lecture slayts and notes. 2. Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter “Essential Cell Biology” Fourth Edition, Garland Science Publishers, USA, 2013. |
| Alberts et al., “Molecular Biology of the Cell" Sixth Edition, Garland Science Publishers, USA, 2017. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Knows structural (morphological) and operational (functional) properties of the normal human (medical) and disorder (disease) states | X | |||||
| 2 | Knows diagnostic methods and treatment modalities of disorders (diseases). | X | |||||
| 3 | Knows the causes of disease conditions, ways of protection and methods of promoting and improving community health. | X | |||||
| 4 | Knows the methods of developing and applying health related knowledge at advanced level. | X | |||||
| 5 | Able to reach multidisciplinary advanced knowledge regarding health-related disciplines, interpret and apply the knowledge. | X | |||||
| 6 | Performs a complete clinical examination of human body structurally and functionally and identifies problems. | ||||||
| 7 | Interprets laboratory results for diagnosis, compares with clinical data and develop solution proposals. | X | |||||
| 8 | Selects and implements appropriate tools for the promotion and development of individual and community health. | ||||||
| 9 | Plans and conducts an advanced study on health independently. | X | |||||
| 10 | Develops new strategic approaches to solve the problems encountered in the promotion and development of individual and community health. | X | |||||
| 11 | Takes the responsibility of any type of practice when diagnosing and treating human body | ||||||
| 12 | Takes the role as a leader or a team worker when solving health related problems. | X | |||||
| 13 | Evaluates knowledge and skills regarding health with a critical approach and develops a positive attitude towards lifelong learning. | X | |||||
| 14 | Informs the patient, related people, institutions and the society about the health problems and transfers solution proposals in writing, verbally and visually using effective communication means. | X | |||||
| 15 | Critically reviews, develops and acts on changes in social relations and norms that guide such relationships. | ||||||
| 16 | Uses English at least at the European Language Portfolio B2 Level, monitors knowledge and communicates in his field. | X | |||||
| 17 | Able to use advanced computer skills and informatics and communication technologies at a level required by the field. | X | |||||
| 18 | Acquires, interprets, implements and announces data related to the health and acts in accordance with social, scientific, cultural and ethical values and teaches these values. | X | |||||
| 19 | Develops strategies, policy and implementation plans in the field of health and evaluates the results obtained within the framework of quality processes. | X | |||||
| 20 | Shares studies on the promotion and development of health with interdisciplinary specialists systematically, supporting with quantitative and qualitative data. | X | |||||
| 21 | Has adequate awareness on occupational health and safety issues. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 40 | |
| Rate of Final Exam to Success | 60 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 33 | 2 | 66 | |||
| Guided Problem Solving | 0 | 0 | 0 | |||
| Resolution of Homework Problems and Submission as a Report | 0 | 0 | 0 | |||
| Term Project | 0 | 0 | 0 | |||
| Presentation of Project / Seminar | 0 | 0 | 0 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 5 | 7 | 35 | |||
| General Exam | 1 | 10 | 10 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 111 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(111/30) | 4 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| MEDICAL BIOLOGY & GENETICS | - | Yearly | 44+10 | - | 4 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | English |
| Course Level | First Cycle (Bachelor's Degree) |
| Course Type | Committee Course |
| Course Coordinator | Prof.Dr. Esra ÇAĞAVİ |
| Name of Lecturer(s) | Assist.Prof. İlyas ÖZÇİÇEK, Assist.Prof. Neşe AYŞİT, Prof.Dr. Esra ÇAĞAVİ, Prof.Dr. Kürşat ÖZDİLLİ, Assist.Prof. Elif Zeynep YILMAZ, Assoc.Prof. Nihal KARAKAŞ, Assist.Prof. Sven Pierre L. VILAIN, Assist.Prof. Salih GENCER, Assist.Prof. Berrak ÇAĞLAYAN |
| Assistant(s) | Prof.Dr. Esra ÇAĞAVİ, Prof.Dr. Kürşat ÖZDİLLİ, Dr.Öğr.Üye. İlyas ÖZÇİÇEK, Dr.Öğr.Üye. Neşe AYŞİT, Dr.Öğr.Üye. Elif Zeynep YILMAZ |
| Aim | The aim of this course is to define the fundamental concepts in cellular, molecular and functional aspects of medical biology and genetics of the cell, to evaluate association of pathologies and homeostasis with molecular mechanisms that will lay the foundation for understanding of basic cellular mechanisms for clinical applications that meets the requirements for medical proficiency and learning objectives. |
| Course Content | This course contains; Fundamentals of Life: The cell and biosynthesis,Proteins: Structure and function ,Lab-1: The laboratory guidelines, micropipette practice, practice in SDS-PAGE ,The genetic material of a cell: DNA, chromosomes and the genome,DNA replication, repair and recombination,RNA structure and function, transciption,Genetic code and translation,The control of gene expression and genetic switches,Epigenetics and cell memory,Lab-2: Polimerase Chain Reaction (PCR),Lab-3: DNA restriction digestion and Agarose gel electrophoresis,The structural properties and function of cell membrane,Intracellular compartments: Organelles I,Intracellular compartments: Organelles-II,Protein sorting and vesicular trafficking in the cell,Endocytosis, exocytosis and membrane transport,Cellular communication and signaling pathways-I,Cellular communication and signaling pathways-II,Cytoskeleton and motor proteins,Lab-4: Florescence Microscopy: Immunocytochemical observation of the cell ,Cellular junctions, cell adhesion and extracellular matrix,Cell Cycle ,Cell senescence and Cell death,Stem Cells and Regeneration,Cancer biology and the molecular basis of cancer,The current therapeutic approaches for cancer,Lab-5: Cell culture applications,The fundamentals of medical genetics,Mendelian Inheritance,Non-mendelian Inheritance ,Autosomal Chromosomal Disorders,Inheritance of Sex Chromosome Disorders ,Prenatal tests and Genetic Counseling. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| Define basic knowledge and concepts in molecular biology and genetics | 14, 9 | C, E |
| Define structure, function, biosynthesis and catabolic mechanisms of macromolecules in the cell | 14, 9 | C, E |
| Explains molecular biology techniques used in the study of molecules and structures that enable the cell to function. | 13, 17, 9 | C, E, G |
| Interpret the cellular processes and the cellular signaling mechanisms | 13, 14, 19, 9 | C, E |
| Define the structure and function of intracellular compartments (organelles) and associated with major organelle pathologies | 14, 9 | C |
| Defnes the basic mechanisms of embryonic development and adult tissue renewal and stem cells, as well as cell death and cell cycle control. | 14, 9 | C, E |
| Discuss the genetic basis of diseases | 10, 13, 14, 9 | C, E |
| Defines the basic molecular principles of cancer | 14, 9 | C, E |
| Explains medical genetics concepts, classification of genetic diseases, basic hereditary disease groups and inheritance principles. | 13, 14, 9 | C |
| Defines basic laboratory rules and practices in the field of medical biology. | 12, 13, 14, 17, 9 | C, E, G |
| Teaching Methods: | 10: Discussion Method, 12: Problem Solving Method, 13: Case Study Method, 14: Self Study Method, 17: Experimental Technique, 19: Brainstorming Technique, 9: Lecture Method |
| Assessment Methods: | C: Multiple-Choice Exam, E: Homework, G: Quiz |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Fundamentals of Life: The cell and biosynthesis | |
| 2 | Proteins: Structure and function | |
| 3 | Lab-1: The laboratory guidelines, micropipette practice, practice in SDS-PAGE | |
| 4 | The genetic material of a cell: DNA, chromosomes and the genome | |
| 5 | DNA replication, repair and recombination | |
| 6 | RNA structure and function, transciption | |
| 7 | Genetic code and translation | |
| 8 | The control of gene expression and genetic switches | |
| 9 | Epigenetics and cell memory | |
| 10 | Lab-2: Polimerase Chain Reaction (PCR) | |
| 11 | Lab-3: DNA restriction digestion and Agarose gel electrophoresis | |
| 12 | The structural properties and function of cell membrane | |
| 13 | Intracellular compartments: Organelles I | |
| 14 | Intracellular compartments: Organelles-II | |
| 15 | Protein sorting and vesicular trafficking in the cell | |
| 16 | Endocytosis, exocytosis and membrane transport | |
| 17 | Cellular communication and signaling pathways-I | |
| 18 | Cellular communication and signaling pathways-II | |
| 19 | Cytoskeleton and motor proteins | |
| 20 | Lab-4: Florescence Microscopy: Immunocytochemical observation of the cell | |
| 21 | Cellular junctions, cell adhesion and extracellular matrix | |
| 22 | Cell Cycle | |
| 23 | Cell senescence and Cell death | |
| 24 | Stem Cells and Regeneration | |
| 25 | Cancer biology and the molecular basis of cancer | |
| 26 | The current therapeutic approaches for cancer | |
| 27 | Lab-5: Cell culture applications | |
| 28 | The fundamentals of medical genetics | |
| 29 | Mendelian Inheritance | |
| 30 | Non-mendelian Inheritance | |
| 31 | Autosomal Chromosomal Disorders | |
| 32 | Inheritance of Sex Chromosome Disorders | |
| 33 | Prenatal tests and Genetic Counseling |
| Resources |
| 1. Lecture slayts and notes. 2. Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter “Essential Cell Biology” Fourth Edition, Garland Science Publishers, USA, 2013. |
| Alberts et al., “Molecular Biology of the Cell" Sixth Edition, Garland Science Publishers, USA, 2017. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Knows structural (morphological) and operational (functional) properties of the normal human (medical) and disorder (disease) states | X | |||||
| 2 | Knows diagnostic methods and treatment modalities of disorders (diseases). | X | |||||
| 3 | Knows the causes of disease conditions, ways of protection and methods of promoting and improving community health. | X | |||||
| 4 | Knows the methods of developing and applying health related knowledge at advanced level. | X | |||||
| 5 | Able to reach multidisciplinary advanced knowledge regarding health-related disciplines, interpret and apply the knowledge. | X | |||||
| 6 | Performs a complete clinical examination of human body structurally and functionally and identifies problems. | ||||||
| 7 | Interprets laboratory results for diagnosis, compares with clinical data and develop solution proposals. | X | |||||
| 8 | Selects and implements appropriate tools for the promotion and development of individual and community health. | ||||||
| 9 | Plans and conducts an advanced study on health independently. | X | |||||
| 10 | Develops new strategic approaches to solve the problems encountered in the promotion and development of individual and community health. | X | |||||
| 11 | Takes the responsibility of any type of practice when diagnosing and treating human body | ||||||
| 12 | Takes the role as a leader or a team worker when solving health related problems. | X | |||||
| 13 | Evaluates knowledge and skills regarding health with a critical approach and develops a positive attitude towards lifelong learning. | X | |||||
| 14 | Informs the patient, related people, institutions and the society about the health problems and transfers solution proposals in writing, verbally and visually using effective communication means. | X | |||||
| 15 | Critically reviews, develops and acts on changes in social relations and norms that guide such relationships. | ||||||
| 16 | Uses English at least at the European Language Portfolio B2 Level, monitors knowledge and communicates in his field. | X | |||||
| 17 | Able to use advanced computer skills and informatics and communication technologies at a level required by the field. | X | |||||
| 18 | Acquires, interprets, implements and announces data related to the health and acts in accordance with social, scientific, cultural and ethical values and teaches these values. | X | |||||
| 19 | Develops strategies, policy and implementation plans in the field of health and evaluates the results obtained within the framework of quality processes. | X | |||||
| 20 | Shares studies on the promotion and development of health with interdisciplinary specialists systematically, supporting with quantitative and qualitative data. | X | |||||
| 21 | Has adequate awareness on occupational health and safety issues. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 40 | |
| Rate of Final Exam to Success | 60 | |
| Total | 100 | |