Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| PHARMACEUTICAL CHEMISTRY I | PHA3114143 | Fall Semester | 3+0 | 3 | 5 |
| Course Program | Perşembe 13:30-14:15 Perşembe 14:30-15:15 Perşembe 15:30-16:15 Perşembe 16:30-17:15 Perşembe 17:30-18:15 Perşembe 18:30-19:15 |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | English |
| Course Level | First Cycle (Bachelor's Degree) |
| Course Type | Required |
| Course Coordinator | Prof.Dr. Mine YARIM YÜKSEL |
| Name of Lecturer(s) | Prof.Dr. Mine YARIM YÜKSEL |
| Assistant(s) | |
| Aim | To evaluate the history of drugs, physicochemical and chemical factors effecting the activities of the drugs, drug metabolism, new drug research and development and their applications. |
| Course Content | This course contains; Introduction to pharmaceutical chemistry, the history of drugs, drug sources, nomenclature and classification ,Physicochemical properties: Solubility of drugs,The determination of solubility,Physicochemical properties: İonization of drugs,The determination of ionization,Chemical properties: Chemical bondings in drug and receptor interactions,Chemical properties: Drug and receptor interactions,Steric factors,Drug metabolism: Phase I reactions ,Drug metabolism: Phase II reactions,Bioisosterism,Structure-activity relationships ,Yeni ilaç geliştirilmesi ,Önilaç: Tasarlanması ve sentezi . |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1. will be able to explain the definicition of pharmaceutical chemistry, the history and general properties of drugs. 1.1. explain the sources of drugs. 1.2. illustrate the nomenclature of the drugs. 1.3. interpret the classification of drugs. 2. will be able to relate the physicochemical properties effecting on the drug activities. 2.1. interpret the relationships between the activities and solubilities of the drugs. 2.2. discuss the relationships between the activities and ionizations of the drugs. 2.3. formulate identifying and calculating the solubility and ionization properties of the drug molucules. 3. will be able to evaluate the relationships between the activities and chemical structures of the drugs. 3.1. evaluate the drug-receptor relationships. 3.2. interpret the role of chemical bonding in drug-receptor relationships. 3.3. discuss the steric effects on the drug activities. 4. will be able to explain the drug metabolism. 4.1. interpret the Faz I drug metabolism reactions. 4.2. interpret the Faz II drug metabolism reactions. 4.3. demonstrate the metabolism products of drugs. 5. will be able to design the structure-activities relationships. 5.1. interpret the parameters using in quantitative structure-activities relationships. 5.3. interpret the electronic and steric parameters. 6. will be able to formulate the studies on development of the new drug molecules. 6.1. illustrate the using the bioisosteric groups in drug development. 6.2. suggest the designing and synthesis of prodrugs. 6.3. report the phase of new drug development from biological system. | 16, 9 | A |
| Teaching Methods: | 16: Question - Answer Technique, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Introduction to pharmaceutical chemistry, the history of drugs, drug sources, nomenclature and classification | Reading the references |
| 2 | Physicochemical properties: Solubility of drugs | Reading the references |
| 3 | The determination of solubility | Reading the references |
| 4 | Physicochemical properties: İonization of drugs | Reading the references |
| 5 | The determination of ionization | Reading the references |
| 6 | Chemical properties: Chemical bondings in drug and receptor interactions | Reading the references |
| 7 | Chemical properties: Drug and receptor interactions | Reading the references |
| 8 | Steric factors | Reading the references |
| 9 | Drug metabolism: Phase I reactions | Reading the references |
| 10 | Drug metabolism: Phase II reactions | Reading the references |
| 11 | Bioisosterism | Reading the references |
| 12 | Structure-activity relationships | Reading the references |
| 13 | Yeni ilaç geliştirilmesi | Reading the references |
| 14 | Önilaç: Tasarlanması ve sentezi | Reading the references |
| Resources |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | PQ-1. Skilfully use information technology to access, follow, evaluate and apply current knowledge in the field of Pharmaceutical Sciences. | X | |||||
| 2 | PQ-2. Have advanced knowledge in APIs and DPs. | X | |||||
| 3 | PQ-3. Collaborate with the experts for collection, interpretation, application and declaration of data in Pharmaceutical Sciences field. | ||||||
| 4 | PQ-4. Provide best patient counseling services and medication therapy management using his/her knowledge and pharmaceutical information systems to improve the quality of life and safety of patient. | ||||||
| 5 | PQ-5. Capable of organizing and administering a drugstore as per responsibilities prescribed under the Pharmacy Law, using skills, knowledge and advanced technology systems. | ||||||
| 6 | PQ-6. Skilfully use computer programs and advanced technology related to the Pharmaceutical Sciences. | ||||||
| 7 | PQ-7. Provide solutions to the professional issues using scientific knowledge and data. | ||||||
| 8 | PQ-8. Perform identification, quality control and standardization of the drug products. | X | |||||
| 9 | PQ-9. Prepare and implement developmental plans for his/her subordinates, frequently evaluate their progress and make necessary adjustments. | ||||||
| 10 | PQ-10. Capable of conducting independent studies with his/her advanced knowledge in pharmaceutical sciences, takes responsibilities in professional organizations and efficiently collaborates with the members of his/her own organization as well as other organizations. | X | |||||
| 11 | PQ-11. Clearly show signs of adoption of life-long learning and openness to further development. | ||||||
| 12 | PQ-12. Critically evaluate their knowledge in pharmaceutical sciences. | ||||||
| 13 | PQ-13. Closely follow and evaluate the national and international professional developments. | X | |||||
| 14 | PQ-14. Record and document all professional activities and applications. | ||||||
| 15 | PQ-15. Communicate all necessary information about medicines to patient, medical personnel and public. | X | |||||
| 16 | PQ-16. Proficient in English to communicate and follow current knowledge in pharmaceutical sciences. | X | |||||
| 17 | PQ-17. Inform officials and organizations about the issues with the quality assurance of pharmaceutical products. | ||||||
| 18 | PQ-18. Actively involve in the preparation of APIs, every stage of the formulation and production of DPs. | X | |||||
| 19 | PQ-19. Knowledgable in the regulatory rules of new drug application, data protection and patent issues and understand their interrelationship. | ||||||
| 20 | PQ-20. Have awareness of his/her duties, rights and responsibilities and act based on Pharmacy Law and high professional ethical standards. | ||||||
| 21 | PQ-21. Familiar with and actively pursue the personal and public health, environmental, and work safety issues. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 40 | |
| Rate of Final Exam to Success | 60 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 3 | 42 | |||
| Guided Problem Solving | 14 | 3 | 42 | |||
| Resolution of Homework Problems and Submission as a Report | 0 | 0 | 0 | |||
| Term Project | 1 | 24 | 24 | |||
| Presentation of Project / Seminar | 0 | 0 | 0 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 21 | 21 | |||
| General Exam | 1 | 21 | 21 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 150 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(150/30) | 5 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| PHARMACEUTICAL CHEMISTRY I | PHA3114143 | Fall Semester | 3+0 | 3 | 5 |
| Course Program | Perşembe 13:30-14:15 Perşembe 14:30-15:15 Perşembe 15:30-16:15 Perşembe 16:30-17:15 Perşembe 17:30-18:15 Perşembe 18:30-19:15 |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | English |
| Course Level | First Cycle (Bachelor's Degree) |
| Course Type | Required |
| Course Coordinator | Prof.Dr. Mine YARIM YÜKSEL |
| Name of Lecturer(s) | Prof.Dr. Mine YARIM YÜKSEL |
| Assistant(s) | |
| Aim | To evaluate the history of drugs, physicochemical and chemical factors effecting the activities of the drugs, drug metabolism, new drug research and development and their applications. |
| Course Content | This course contains; Introduction to pharmaceutical chemistry, the history of drugs, drug sources, nomenclature and classification ,Physicochemical properties: Solubility of drugs,The determination of solubility,Physicochemical properties: İonization of drugs,The determination of ionization,Chemical properties: Chemical bondings in drug and receptor interactions,Chemical properties: Drug and receptor interactions,Steric factors,Drug metabolism: Phase I reactions ,Drug metabolism: Phase II reactions,Bioisosterism,Structure-activity relationships ,Yeni ilaç geliştirilmesi ,Önilaç: Tasarlanması ve sentezi . |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1. will be able to explain the definicition of pharmaceutical chemistry, the history and general properties of drugs. 1.1. explain the sources of drugs. 1.2. illustrate the nomenclature of the drugs. 1.3. interpret the classification of drugs. 2. will be able to relate the physicochemical properties effecting on the drug activities. 2.1. interpret the relationships between the activities and solubilities of the drugs. 2.2. discuss the relationships between the activities and ionizations of the drugs. 2.3. formulate identifying and calculating the solubility and ionization properties of the drug molucules. 3. will be able to evaluate the relationships between the activities and chemical structures of the drugs. 3.1. evaluate the drug-receptor relationships. 3.2. interpret the role of chemical bonding in drug-receptor relationships. 3.3. discuss the steric effects on the drug activities. 4. will be able to explain the drug metabolism. 4.1. interpret the Faz I drug metabolism reactions. 4.2. interpret the Faz II drug metabolism reactions. 4.3. demonstrate the metabolism products of drugs. 5. will be able to design the structure-activities relationships. 5.1. interpret the parameters using in quantitative structure-activities relationships. 5.3. interpret the electronic and steric parameters. 6. will be able to formulate the studies on development of the new drug molecules. 6.1. illustrate the using the bioisosteric groups in drug development. 6.2. suggest the designing and synthesis of prodrugs. 6.3. report the phase of new drug development from biological system. | 16, 9 | A |
| Teaching Methods: | 16: Question - Answer Technique, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Introduction to pharmaceutical chemistry, the history of drugs, drug sources, nomenclature and classification | Reading the references |
| 2 | Physicochemical properties: Solubility of drugs | Reading the references |
| 3 | The determination of solubility | Reading the references |
| 4 | Physicochemical properties: İonization of drugs | Reading the references |
| 5 | The determination of ionization | Reading the references |
| 6 | Chemical properties: Chemical bondings in drug and receptor interactions | Reading the references |
| 7 | Chemical properties: Drug and receptor interactions | Reading the references |
| 8 | Steric factors | Reading the references |
| 9 | Drug metabolism: Phase I reactions | Reading the references |
| 10 | Drug metabolism: Phase II reactions | Reading the references |
| 11 | Bioisosterism | Reading the references |
| 12 | Structure-activity relationships | Reading the references |
| 13 | Yeni ilaç geliştirilmesi | Reading the references |
| 14 | Önilaç: Tasarlanması ve sentezi | Reading the references |
| Resources |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | PQ-1. Skilfully use information technology to access, follow, evaluate and apply current knowledge in the field of Pharmaceutical Sciences. | X | |||||
| 2 | PQ-2. Have advanced knowledge in APIs and DPs. | X | |||||
| 3 | PQ-3. Collaborate with the experts for collection, interpretation, application and declaration of data in Pharmaceutical Sciences field. | ||||||
| 4 | PQ-4. Provide best patient counseling services and medication therapy management using his/her knowledge and pharmaceutical information systems to improve the quality of life and safety of patient. | ||||||
| 5 | PQ-5. Capable of organizing and administering a drugstore as per responsibilities prescribed under the Pharmacy Law, using skills, knowledge and advanced technology systems. | ||||||
| 6 | PQ-6. Skilfully use computer programs and advanced technology related to the Pharmaceutical Sciences. | ||||||
| 7 | PQ-7. Provide solutions to the professional issues using scientific knowledge and data. | ||||||
| 8 | PQ-8. Perform identification, quality control and standardization of the drug products. | X | |||||
| 9 | PQ-9. Prepare and implement developmental plans for his/her subordinates, frequently evaluate their progress and make necessary adjustments. | ||||||
| 10 | PQ-10. Capable of conducting independent studies with his/her advanced knowledge in pharmaceutical sciences, takes responsibilities in professional organizations and efficiently collaborates with the members of his/her own organization as well as other organizations. | X | |||||
| 11 | PQ-11. Clearly show signs of adoption of life-long learning and openness to further development. | ||||||
| 12 | PQ-12. Critically evaluate their knowledge in pharmaceutical sciences. | ||||||
| 13 | PQ-13. Closely follow and evaluate the national and international professional developments. | X | |||||
| 14 | PQ-14. Record and document all professional activities and applications. | ||||||
| 15 | PQ-15. Communicate all necessary information about medicines to patient, medical personnel and public. | X | |||||
| 16 | PQ-16. Proficient in English to communicate and follow current knowledge in pharmaceutical sciences. | X | |||||
| 17 | PQ-17. Inform officials and organizations about the issues with the quality assurance of pharmaceutical products. | ||||||
| 18 | PQ-18. Actively involve in the preparation of APIs, every stage of the formulation and production of DPs. | X | |||||
| 19 | PQ-19. Knowledgable in the regulatory rules of new drug application, data protection and patent issues and understand their interrelationship. | ||||||
| 20 | PQ-20. Have awareness of his/her duties, rights and responsibilities and act based on Pharmacy Law and high professional ethical standards. | ||||||
| 21 | PQ-21. Familiar with and actively pursue the personal and public health, environmental, and work safety issues. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 40 | |
| Rate of Final Exam to Success | 60 | |
| Total | 100 | |