Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| PHARMACEUTICAL CHEMISTRY I | - | Fall Semester | 3+0 | 3 | 5 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | First Cycle (Bachelor's Degree) |
| Course Type | Required |
| Course Coordinator | Prof.Dr. Seda ÜNSALAN |
| Name of Lecturer(s) | Assist.Prof. Hacer KARATAŞ BRISTOW |
| Assistant(s) | |
| Aim | To evaluate the history of drugs, physicochemical and chemical factors effecting the activities of the drugs, drug metabolism, new drug research and development and their applications. |
| Course Content | This course contains; Introduction to pharmaceutical chemistry, the history of drugs, drug sources, nomenclature and classification,Physicochemical properties: Solubility of drugs,The determination of solubility,Physicochemical properties: İonization of drugs,The determination of ionization,Chemical properties: Chemical bondings in drug and receptor interactions,Chemical properties: Drug and receptor interactions,Steric factors,Drug metabolism: Phase I reactions,Drug metabolism: Phase II reactions,Bioizosterism,Structure-activity relationships,New drug development,Prodrog: Designing and synthesis. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 5.2.discuss the solubility parameters. | 16, 19, 9 | A |
| 1. will be able to explain the definicition of pharmaceutical chemistry, the history and general properties of drugs. | 16, 19, 9 | A |
| 1.1. explain the sources of drugs. | 16, 19, 9 | A |
| 1.2. illustrate the nomenclature of the drugs. | 16, 19, 9 | A |
| 1.3. interpret the classification of drugs. | 16, 19, 9 | A |
| 2. will be able to relate the physicochemical properties effecting on the drug activities. | 16, 19, 9 | A |
| 2.1. interpret the relationships between the activities and solubilities of the drugs. | 16, 19, 9 | A |
| 2.2. discuss the relationships between the activities and ionizations of the drugs. | 16, 19, 9 | A |
| 2.3. formulate identifying and calculating the solubility and ionization properties of the drug molucules. | 16, 19, 9 | A |
| 3. will be able to evaluate the relationships between the activities and chemical structures of the drugs. | 16, 19, 9 | A |
| 3.1. evaluate the drug-receptor relationships. | 16, 19, 9 | A |
| 3.2. interpret the role of chemical bonding in drug-receptor relationships. | 16, 19, 9 | A |
| 3.3. discuss the steric effects on the drug activities. | 16, 19, 9 | A |
| 4. will be able to explain the drug metabolism. | 16, 19, 9 | A |
| 4.1. interpret the Faz I drug metabolism reactions. | 16, 19, 9 | A |
| 4.2. interpret the Faz II drug metabolism reactions. | 16, 19, 9 | A |
| 4.3. demonstrate the metabolism products of drugs. | 16, 19, 9 | A |
| 5. will be able to design the structure-activities relationships. | 16, 19, 9 | A |
| 5.1. interpret the parameters using in quantitative structure-activities relationships. | 16, 19, 9 | A |
| 5.3. interpret the electronic and steric parameters. | 16, 19, 9 | A |
| 6. will be able to formulate the studies on development of the new drug molecules. | 16, 19, 9 | A |
| 6.1. illustrate the using the bioisosteric groups in drug development. | 16, 19, 9 | A |
| 6.2. suggest the designing and synthesis of prodrugs. | 16, 19, 9 | A |
| 6.3. report the phase of new drug development from biological system. | 16, 19, 9 | A |
| Teaching Methods: | 16: Question - Answer Technique, 19: Brainstorming Technique, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Introduction to pharmaceutical chemistry, the history of drugs, drug sources, nomenclature and classification | 1 |
| 2 | Physicochemical properties: Solubility of drugs | 1 |
| 3 | The determination of solubility | 1 |
| 4 | Physicochemical properties: İonization of drugs | 1 |
| 5 | The determination of ionization | 1 |
| 6 | Chemical properties: Chemical bondings in drug and receptor interactions | 1 |
| 7 | Chemical properties: Drug and receptor interactions | 1 |
| 8 | Steric factors | 1 |
| 9 | Drug metabolism: Phase I reactions | 1 |
| 10 | Drug metabolism: Phase II reactions | 1 |
| 11 | Bioizosterism | 1 |
| 12 | Structure-activity relationships | 1 |
| 13 | New drug development | 1 |
| 14 | Prodrog: Designing and synthesis | 1 |
| Resources |
| The Pharmaceutical Chemistry notes will be given to the students. |
| 1. Farmasötik Kimya. Hacettepe Üniversitesi Yayınları, Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı Öğretim Üyeleri. (2004), Ankara. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | PQ-1. Skilfully use information technology to access, follow, evaluate and apply current knowledge in the field of Pharmaceutical Sciences. | X | |||||
| 2 | PQ-2. Have advanced knowledge in APIs and DPs. | X | |||||
| 3 | PQ-3. Collaborate with the experts for collection, interpretation, application and declaration of data in Pharmaceutical Sciences field. | X | |||||
| 4 | PQ-4. Provide best patient counseling services and medication therapy management using his/her knowledge and pharmaceutical information systems to improve the quality of life and safety of patient. | X | |||||
| 5 | PQ-5. Capable of organizing and administering a drugstore as per responsibilities prescribed under the Pharmacy Law, using skills, knowledge and advanced technology systems. | X | |||||
| 6 | PQ-6. Skilfully use computer programs and advanced technology related to the Pharmaceutical Sciences. | X | |||||
| 7 | PQ-7. Provide solutions to the professional issues using scientific knowledge and data. | X | |||||
| 8 | PQ-8. Perform identification, quality control and standardization of the drug products. | X | |||||
| 9 | PQ-9. Prepare and implement developmental plans for his/her subordinates, frequently evaluate their progress and make necessary adjustments. | X | |||||
| 10 | PQ-10. Capable of conducting independent studies with his/her advanced knowledge in pharmaceutical sciences, takes responsibilities in professional organizations and efficiently collaborates with the members of his/her own organization as well as other organizations. | X | |||||
| 11 | PQ-11. Clearly show signs of adoption of life-long learning and openness to further development. | X | |||||
| 12 | PQ-12. Critically evaluate their knowledge in pharmaceutical sciences. | X | |||||
| 13 | PQ-13. Closely follow and evaluate the national and international professional developments. | X | |||||
| 14 | PQ-14. Record and document all professional activities and applications. | X | |||||
| 15 | PQ-15. Communicate all necessary information about medicines to patient, medical personnel and public. | X | |||||
| 16 | PQ-16. Proficient in English to communicate and follow current knowledge in pharmaceutical sciences. | X | |||||
| 17 | PQ-17. Inform officials and organizations about the issues with the quality assurance of pharmaceutical products. | X | |||||
| 18 | PQ-18. Actively involve in the preparation of APIs, every stage of the formulation and production of DPs. | X | |||||
| 19 | PQ-19. Knowledgable in the regulatory rules of new drug application, data protection and patent issues and understand their interrelationship. | X | |||||
| 20 | PQ-20. Have awareness of his/her duties, rights and responsibilities and act based on Pharmacy Law and high professional ethical standards. | X | |||||
| 21 | PQ-21. Familiar with and actively pursue the personal and public health, environmental, and work safety issues. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 40 | |
| Rate of Final Exam to Success | 60 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 3 | 42 | |||
| Guided Problem Solving | 14 | 3 | 42 | |||
| Resolution of Homework Problems and Submission as a Report | 14 | 2 | 28 | |||
| Term Project | 5 | 2 | 10 | |||
| Presentation of Project / Seminar | 0 | 0 | 0 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 14 | 14 | |||
| General Exam | 1 | 20 | 20 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 156 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(156/30) | 5 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| PHARMACEUTICAL CHEMISTRY I | - | Fall Semester | 3+0 | 3 | 5 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | First Cycle (Bachelor's Degree) |
| Course Type | Required |
| Course Coordinator | Prof.Dr. Seda ÜNSALAN |
| Name of Lecturer(s) | Assist.Prof. Hacer KARATAŞ BRISTOW |
| Assistant(s) | |
| Aim | To evaluate the history of drugs, physicochemical and chemical factors effecting the activities of the drugs, drug metabolism, new drug research and development and their applications. |
| Course Content | This course contains; Introduction to pharmaceutical chemistry, the history of drugs, drug sources, nomenclature and classification,Physicochemical properties: Solubility of drugs,The determination of solubility,Physicochemical properties: İonization of drugs,The determination of ionization,Chemical properties: Chemical bondings in drug and receptor interactions,Chemical properties: Drug and receptor interactions,Steric factors,Drug metabolism: Phase I reactions,Drug metabolism: Phase II reactions,Bioizosterism,Structure-activity relationships,New drug development,Prodrog: Designing and synthesis. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 5.2.discuss the solubility parameters. | 16, 19, 9 | A |
| 1. will be able to explain the definicition of pharmaceutical chemistry, the history and general properties of drugs. | 16, 19, 9 | A |
| 1.1. explain the sources of drugs. | 16, 19, 9 | A |
| 1.2. illustrate the nomenclature of the drugs. | 16, 19, 9 | A |
| 1.3. interpret the classification of drugs. | 16, 19, 9 | A |
| 2. will be able to relate the physicochemical properties effecting on the drug activities. | 16, 19, 9 | A |
| 2.1. interpret the relationships between the activities and solubilities of the drugs. | 16, 19, 9 | A |
| 2.2. discuss the relationships between the activities and ionizations of the drugs. | 16, 19, 9 | A |
| 2.3. formulate identifying and calculating the solubility and ionization properties of the drug molucules. | 16, 19, 9 | A |
| 3. will be able to evaluate the relationships between the activities and chemical structures of the drugs. | 16, 19, 9 | A |
| 3.1. evaluate the drug-receptor relationships. | 16, 19, 9 | A |
| 3.2. interpret the role of chemical bonding in drug-receptor relationships. | 16, 19, 9 | A |
| 3.3. discuss the steric effects on the drug activities. | 16, 19, 9 | A |
| 4. will be able to explain the drug metabolism. | 16, 19, 9 | A |
| 4.1. interpret the Faz I drug metabolism reactions. | 16, 19, 9 | A |
| 4.2. interpret the Faz II drug metabolism reactions. | 16, 19, 9 | A |
| 4.3. demonstrate the metabolism products of drugs. | 16, 19, 9 | A |
| 5. will be able to design the structure-activities relationships. | 16, 19, 9 | A |
| 5.1. interpret the parameters using in quantitative structure-activities relationships. | 16, 19, 9 | A |
| 5.3. interpret the electronic and steric parameters. | 16, 19, 9 | A |
| 6. will be able to formulate the studies on development of the new drug molecules. | 16, 19, 9 | A |
| 6.1. illustrate the using the bioisosteric groups in drug development. | 16, 19, 9 | A |
| 6.2. suggest the designing and synthesis of prodrugs. | 16, 19, 9 | A |
| 6.3. report the phase of new drug development from biological system. | 16, 19, 9 | A |
| Teaching Methods: | 16: Question - Answer Technique, 19: Brainstorming Technique, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Introduction to pharmaceutical chemistry, the history of drugs, drug sources, nomenclature and classification | 1 |
| 2 | Physicochemical properties: Solubility of drugs | 1 |
| 3 | The determination of solubility | 1 |
| 4 | Physicochemical properties: İonization of drugs | 1 |
| 5 | The determination of ionization | 1 |
| 6 | Chemical properties: Chemical bondings in drug and receptor interactions | 1 |
| 7 | Chemical properties: Drug and receptor interactions | 1 |
| 8 | Steric factors | 1 |
| 9 | Drug metabolism: Phase I reactions | 1 |
| 10 | Drug metabolism: Phase II reactions | 1 |
| 11 | Bioizosterism | 1 |
| 12 | Structure-activity relationships | 1 |
| 13 | New drug development | 1 |
| 14 | Prodrog: Designing and synthesis | 1 |
| Resources |
| The Pharmaceutical Chemistry notes will be given to the students. |
| 1. Farmasötik Kimya. Hacettepe Üniversitesi Yayınları, Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı Öğretim Üyeleri. (2004), Ankara. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | PQ-1. Skilfully use information technology to access, follow, evaluate and apply current knowledge in the field of Pharmaceutical Sciences. | X | |||||
| 2 | PQ-2. Have advanced knowledge in APIs and DPs. | X | |||||
| 3 | PQ-3. Collaborate with the experts for collection, interpretation, application and declaration of data in Pharmaceutical Sciences field. | X | |||||
| 4 | PQ-4. Provide best patient counseling services and medication therapy management using his/her knowledge and pharmaceutical information systems to improve the quality of life and safety of patient. | X | |||||
| 5 | PQ-5. Capable of organizing and administering a drugstore as per responsibilities prescribed under the Pharmacy Law, using skills, knowledge and advanced technology systems. | X | |||||
| 6 | PQ-6. Skilfully use computer programs and advanced technology related to the Pharmaceutical Sciences. | X | |||||
| 7 | PQ-7. Provide solutions to the professional issues using scientific knowledge and data. | X | |||||
| 8 | PQ-8. Perform identification, quality control and standardization of the drug products. | X | |||||
| 9 | PQ-9. Prepare and implement developmental plans for his/her subordinates, frequently evaluate their progress and make necessary adjustments. | X | |||||
| 10 | PQ-10. Capable of conducting independent studies with his/her advanced knowledge in pharmaceutical sciences, takes responsibilities in professional organizations and efficiently collaborates with the members of his/her own organization as well as other organizations. | X | |||||
| 11 | PQ-11. Clearly show signs of adoption of life-long learning and openness to further development. | X | |||||
| 12 | PQ-12. Critically evaluate their knowledge in pharmaceutical sciences. | X | |||||
| 13 | PQ-13. Closely follow and evaluate the national and international professional developments. | X | |||||
| 14 | PQ-14. Record and document all professional activities and applications. | X | |||||
| 15 | PQ-15. Communicate all necessary information about medicines to patient, medical personnel and public. | X | |||||
| 16 | PQ-16. Proficient in English to communicate and follow current knowledge in pharmaceutical sciences. | X | |||||
| 17 | PQ-17. Inform officials and organizations about the issues with the quality assurance of pharmaceutical products. | X | |||||
| 18 | PQ-18. Actively involve in the preparation of APIs, every stage of the formulation and production of DPs. | X | |||||
| 19 | PQ-19. Knowledgable in the regulatory rules of new drug application, data protection and patent issues and understand their interrelationship. | X | |||||
| 20 | PQ-20. Have awareness of his/her duties, rights and responsibilities and act based on Pharmacy Law and high professional ethical standards. | X | |||||
| 21 | PQ-21. Familiar with and actively pursue the personal and public health, environmental, and work safety issues. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 40 | |
| Rate of Final Exam to Success | 60 | |
| Total | 100 | |