Medipol University

Course Detail

Ders Detayı

Course Description

CourseCodeSemesterT+P (Hour)CreditECTS
CLINICAL ENZYMOLOGY-Spring Semester2+238
Course Program
Prerequisites Courses
Recommended Elective Courses
Language of CourseTurkish
Course LevelThird Cycle (Doctorate Degree)
Course TypeElective
Course CoordinatorAssist.Prof. Gözde ÜLFER
Name of Lecturer(s)Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assist.Prof. Çağrı ÇAKICI, Assist.Prof. Derya CANSIZ
Assistant(s)
AimTo gain advanced knowledge about enzymes and enzymatic reactions and to discuss potential enzyme-based drug development
Course ContentThis course contains; 1-General properties of the enzymes,2-Classification of the enzymes,3-Isoenzymes,4-Cofactors,5-Factors affectşng enzyme reactions,6-Enzyme Kinetics,7-Enzyme inhibitors,8-Catalytic activity of enzymes and drugs,9-Analysis of enzyme activity,10-Acid and ve alkali phosphatase (3.1.3.2 and 3.1.3.1),11-ACE (3.4.15.1),12-Laktate dehydrogenase (EC 1.1.1.27),13-5’Nucleotidase (EC 3.1.3.5),14-Other enzymes.
Dersin Öğrenme KazanımlarıTeaching MethodsAssessment Methods
1-Explains general properties of the enzymes10, 11, 16, 19, 6, 9A, D, E
1.1.Explains catalyzer effect of the enzymes10, 11, 16, 19, 6, 9A, D, E
1.2.Explain substrate specificity property of the enzymes10, 11, 16, 19, 6, 9A, D, E
1.3.Explains the molecular basis of the catalytic property10, 11, 16, 19, 6, 9A, D, E
1.4.Explain isoenzymes and related pathological conditions10, 11, 16, 19, 6, 9A, D, E
1.5.Explain coenzymes and cofactors10, 11, 16, 19, 6, 9A, D, E
1.6.Explain half-life of enzymes in blood10, 11, 16, 19, 6, 9A, D, E
2-Explain classification of the enzymes10, 11, 16, 19, 6, 9A, D, E
2.1.Explain main and sub groups of enzymes10, 11, 16, 19, 6, 9A, D, E
2.2.Explain specificity of carbon bonds for classification10, 11, 16, 19, 6, 9A, D, E
3-Question reactions of the enzymes10, 11, 16, 19, 6, 9A, D, E
3.1.Explain the factors affecting enzymatic reactions10, 11, 16, 19, 6, 9A, D, E
3.2.Explain Michaelis-Menten constant and its importance for enzymes10, 11, 16, 19, 6, 9A, D, E
3.3.Explain how to draw Lineweaver-Burk linear10, 11, 16, 19, 6, 9A, D, E
3.4.Question Km value10, 11, 16, 19, 6, 9A, D, E
4-Question enzyme activators and inhibitors10, 11, 16, 19, 6, 9A, D, E
4.1.Explain competitive inhibition10, 11, 16, 19, 6, 9A, D, E
4.2.Explain uncompetitive inhibition10, 11, 16, 19, 6, 9A, D, E
4.4.Develop new ideas for the development of enzyme-based drugs10, 11, 16, 19, 6, 9A, D, E
5-Discuss enzymes that are responsible for energy conversion from nutrition10, 11, 16, 19, 6, 9A, D, E
5.1.Describe mechanism action of enzymes in the first main group10, 11, 16, 19, 6, 9A, D, E
5.2.Describe mechanism action of enzymes in the second main group10, 11, 16, 19, 6, 9A, D, E
5.3.Question mechanism action of enzymes in the third main group10, 11, 16, 19, 6, 9A, D, E
5.4.Question mechanism action of enzymes in the other main groups10, 11, 16, 19, 6, 9A, D, E
2.3. Explain how to isolate enzymes from blood, cell and from other body fluids10, 11, 16, 19, 6, 9A, D, E
4.3. Explain noncompetitive inhibition10, 11, 16, 19, 6, 9A, D, E
Teaching Methods:10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method
Assessment Methods:A: Traditional Written Exam, D: Oral Exam, E: Homework

Course Outline

OrderSubjectsPreliminary Work
11-General properties of the enzymes1, 2, 3, 4, 5
22-Classification of the enzymes1, 2, 3, 4, 5
33-Isoenzymes1, 2, 3, 4, 5
44-Cofactors1, 2, 3, 4, 5
55-Factors affectşng enzyme reactions1, 2, 3, 4, 5
66-Enzyme Kinetics1, 2, 3, 4, 5
77-Enzyme inhibitors1, 2, 3, 4, 5
88-Catalytic activity of enzymes and drugs1, 2, 3, 4, 5
99-Analysis of enzyme activity1, 2, 3, 4, 5
1010-Acid and ve alkali phosphatase (3.1.3.2 and 3.1.3.1)1, 2, 3, 4, 5
1111-ACE (3.4.15.1)1, 2, 3, 4, 5
1212-Laktate dehydrogenase (EC 1.1.1.27)1, 2, 3, 4, 5
1313-5’Nucleotidase (EC 3.1.3.5)1, 2, 3, 4, 5
1414-Other enzymes1, 2, 3, 4, 5
Resources
Published books of Prof. Dr. Nesrin Emekli ve Assoc Prof. Dr. Türkan Yiğitbaşı
Henry's Clinical diagnosis and Managemen by laboratory methods Lehninger Biochemistry Kaplan & Pesce Clinical Biochemistry

Course Contribution to Program Qualifications

Course Contribution to Program Qualifications
NoProgram QualificationContribution Level
12345
1
Defines macro and micromolecules in cell and body fluids at an advanced level.
2
Knows how to store and protect the material to be analyzed.
3
Knows how to identify molecules found in cells and body fluids.
4
Knows the principles of technologies to be used for routine and research purposes.
5
Knows how to evaluate the results of the study, interprets and questions.
6
Knows how to use field-specific tools and equipment
7
Knows how to access and interpret field-specific resources and information
8
Shares information with disciplines related to the field
9
Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals.
10
Solves a scientific and technical problem, knows where to get help.
11
Takes responsibility in joint scientific studies, contributes and works in harmony.
12
Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field.
13
Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially.
14
Can take part in management activities, evaluate the results obtained to improve quality

Assessment Methods

Contribution LevelAbsolute Evaluation
Rate of Midterm Exam to Success 50
Rate of Final Exam to Success 50
Total 100
ECTS / Workload Table
ActivitiesNumber ofDuration(Hour)Total Workload(Hour)
Course Hours14228
Guided Problem Solving1412168
Resolution of Homework Problems and Submission as a Report000
Term Project000
Presentation of Project / Seminar000
Quiz000
Midterm Exam000
General Exam000
Performance Task, Maintenance Plan000
Total Workload(Hour)196
Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(196/30)7
ECTS of the course: 30 hours of work is counted as 1 ECTS credit.

Detail Informations of the Course

Course Description

CourseCodeSemesterT+P (Hour)CreditECTS
CLINICAL ENZYMOLOGY-Spring Semester2+238
Course Program
Prerequisites Courses
Recommended Elective Courses
Language of CourseTurkish
Course LevelThird Cycle (Doctorate Degree)
Course TypeElective
Course CoordinatorAssist.Prof. Gözde ÜLFER
Name of Lecturer(s)Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assist.Prof. Çağrı ÇAKICI, Assist.Prof. Derya CANSIZ
Assistant(s)
AimTo gain advanced knowledge about enzymes and enzymatic reactions and to discuss potential enzyme-based drug development
Course ContentThis course contains; 1-General properties of the enzymes,2-Classification of the enzymes,3-Isoenzymes,4-Cofactors,5-Factors affectşng enzyme reactions,6-Enzyme Kinetics,7-Enzyme inhibitors,8-Catalytic activity of enzymes and drugs,9-Analysis of enzyme activity,10-Acid and ve alkali phosphatase (3.1.3.2 and 3.1.3.1),11-ACE (3.4.15.1),12-Laktate dehydrogenase (EC 1.1.1.27),13-5’Nucleotidase (EC 3.1.3.5),14-Other enzymes.
Dersin Öğrenme KazanımlarıTeaching MethodsAssessment Methods
1-Explains general properties of the enzymes10, 11, 16, 19, 6, 9A, D, E
1.1.Explains catalyzer effect of the enzymes10, 11, 16, 19, 6, 9A, D, E
1.2.Explain substrate specificity property of the enzymes10, 11, 16, 19, 6, 9A, D, E
1.3.Explains the molecular basis of the catalytic property10, 11, 16, 19, 6, 9A, D, E
1.4.Explain isoenzymes and related pathological conditions10, 11, 16, 19, 6, 9A, D, E
1.5.Explain coenzymes and cofactors10, 11, 16, 19, 6, 9A, D, E
1.6.Explain half-life of enzymes in blood10, 11, 16, 19, 6, 9A, D, E
2-Explain classification of the enzymes10, 11, 16, 19, 6, 9A, D, E
2.1.Explain main and sub groups of enzymes10, 11, 16, 19, 6, 9A, D, E
2.2.Explain specificity of carbon bonds for classification10, 11, 16, 19, 6, 9A, D, E
3-Question reactions of the enzymes10, 11, 16, 19, 6, 9A, D, E
3.1.Explain the factors affecting enzymatic reactions10, 11, 16, 19, 6, 9A, D, E
3.2.Explain Michaelis-Menten constant and its importance for enzymes10, 11, 16, 19, 6, 9A, D, E
3.3.Explain how to draw Lineweaver-Burk linear10, 11, 16, 19, 6, 9A, D, E
3.4.Question Km value10, 11, 16, 19, 6, 9A, D, E
4-Question enzyme activators and inhibitors10, 11, 16, 19, 6, 9A, D, E
4.1.Explain competitive inhibition10, 11, 16, 19, 6, 9A, D, E
4.2.Explain uncompetitive inhibition10, 11, 16, 19, 6, 9A, D, E
4.4.Develop new ideas for the development of enzyme-based drugs10, 11, 16, 19, 6, 9A, D, E
5-Discuss enzymes that are responsible for energy conversion from nutrition10, 11, 16, 19, 6, 9A, D, E
5.1.Describe mechanism action of enzymes in the first main group10, 11, 16, 19, 6, 9A, D, E
5.2.Describe mechanism action of enzymes in the second main group10, 11, 16, 19, 6, 9A, D, E
5.3.Question mechanism action of enzymes in the third main group10, 11, 16, 19, 6, 9A, D, E
5.4.Question mechanism action of enzymes in the other main groups10, 11, 16, 19, 6, 9A, D, E
2.3. Explain how to isolate enzymes from blood, cell and from other body fluids10, 11, 16, 19, 6, 9A, D, E
4.3. Explain noncompetitive inhibition10, 11, 16, 19, 6, 9A, D, E
Teaching Methods:10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method
Assessment Methods:A: Traditional Written Exam, D: Oral Exam, E: Homework

Course Outline

OrderSubjectsPreliminary Work
11-General properties of the enzymes1, 2, 3, 4, 5
22-Classification of the enzymes1, 2, 3, 4, 5
33-Isoenzymes1, 2, 3, 4, 5
44-Cofactors1, 2, 3, 4, 5
55-Factors affectşng enzyme reactions1, 2, 3, 4, 5
66-Enzyme Kinetics1, 2, 3, 4, 5
77-Enzyme inhibitors1, 2, 3, 4, 5
88-Catalytic activity of enzymes and drugs1, 2, 3, 4, 5
99-Analysis of enzyme activity1, 2, 3, 4, 5
1010-Acid and ve alkali phosphatase (3.1.3.2 and 3.1.3.1)1, 2, 3, 4, 5
1111-ACE (3.4.15.1)1, 2, 3, 4, 5
1212-Laktate dehydrogenase (EC 1.1.1.27)1, 2, 3, 4, 5
1313-5’Nucleotidase (EC 3.1.3.5)1, 2, 3, 4, 5
1414-Other enzymes1, 2, 3, 4, 5
Resources
Published books of Prof. Dr. Nesrin Emekli ve Assoc Prof. Dr. Türkan Yiğitbaşı
Henry's Clinical diagnosis and Managemen by laboratory methods Lehninger Biochemistry Kaplan & Pesce Clinical Biochemistry

Course Contribution to Program Qualifications

Course Contribution to Program Qualifications
NoProgram QualificationContribution Level
12345
1
Defines macro and micromolecules in cell and body fluids at an advanced level.
2
Knows how to store and protect the material to be analyzed.
3
Knows how to identify molecules found in cells and body fluids.
4
Knows the principles of technologies to be used for routine and research purposes.
5
Knows how to evaluate the results of the study, interprets and questions.
6
Knows how to use field-specific tools and equipment
7
Knows how to access and interpret field-specific resources and information
8
Shares information with disciplines related to the field
9
Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals.
10
Solves a scientific and technical problem, knows where to get help.
11
Takes responsibility in joint scientific studies, contributes and works in harmony.
12
Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field.
13
Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially.
14
Can take part in management activities, evaluate the results obtained to improve quality

Assessment Methods

Contribution LevelAbsolute Evaluation
Rate of Midterm Exam to Success 50
Rate of Final Exam to Success 50
Total 100

Numerical Data

Student Success

Ekleme Tarihi: 27/11/2023 - 02:24Son Güncelleme Tarihi: 27/11/2023 - 02:25
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