Ders Detayı
Course Description
Course | Code | Semester | T+P (Hour) | Credit | ECTS |
---|---|---|---|---|---|
HEMOSTASIS BIOCHEMISTRY II | - | Fall Semester | 2+2 | 3 | 8 |
Course Program |
Prerequisites Courses | |
Recommended Elective Courses |
Language of Course | Turkish |
Course Level | Third Cycle (Doctorate Degree) |
Course Type | Elective |
Course Coordinator | |
Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER |
Assistant(s) | |
Aim | Understand biochemical reaction during bleeding and thrombosis, discuss the relation of the clinics with the hemostatic system |
Course Content | This course contains; Biochemical properties of endothelium (II),Platelet metabolism and function (II),Measurement of platelet functions (II),Coagulation proteins,Laboratory tests about coagulation proteins,Oral anticoagulants,Tissue factor and tissue factor pathway inhibitors (II),Isolation of coagulation proteins (I),Isolation of coagulation proteins (II),Heparin structure and function in hemostatic system,Structure and function of protein C (II),General basis of coagulation inhibitors,Fibrinolytic system,Atherosclerosis in aspect of hemostasis. |
Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
1-At the end of this course, the students will be able to; | 10, 11, 16, 19, 6, 9 | A, D, E |
1.1Understands what endothelial damage is and evaluates the results. | 10, 11, 16, 19, 6, 9 | A, D, E |
1.2.Defines what haemostatic factors are found in the subendothelium. | 10, 11, 16, 19, 6, 9 | A, D, E |
1.3.Explain the functions of proteins released from the endothelium. | 10, 11, 16, 19, 6, 9 | A, D, E |
1.4.It questions why blood circulates in the vein without clotting. | 10, 11, 16, 19, 6, 9 | A, D, E |
2.1.Explain the adhesion of platelets and evaluate the pathology. | 10, 11, 16, 19, 6, 9 | A, D, E |
2.2.Definitions platelet secretion and explains the pathology. | 10, 11, 16, 19, 6, 9 | A, D, E |
2.4.Evaluates platelet function in thrombus-prone conditions. | 10, 11, 16, 19, 6, 9 | A, D, E |
3-Evaluate overview of thrombosis in biochemical aspects | 10, 11, 16, 19, 6, 9 | A, D, E |
3.1.Explain how platelet adhesion is measured. | 10, 11, 16, 19, 6, 9 | A, D, E |
3.4.Explains the relationship between antiaggregant platelet. | 10, 11, 16, 19, 6, 9 | A, D, E |
4-Discuss the properties and measurement of coagulation proteins in the blood | 10, 11, 16, 19, 6, 9 | A, D, E |
4.Learn the properties and measurement of contact activation factor | 10, 11, 16, 19, 6, 9 | A, D, E |
4.1.Explain the importance of contact activation proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
4.2.Explain the difference between extrinsic system and intrinsic system proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
4.3.Explains the proteins in the common pathway and the activity of platelets. | 10, 11, 16, 19, 6, 9 | A, D, E |
4.4.Develops ideas related to the balancing of thrombin and fibrin in pathological conditions. | 10, 11, 16, 19, 6, 9 | A, D, E |
4.5.Explains the relationship between oral anticoagulants and coagulation. | 10, 11, 16, 19, 6, 9 | A, D, E |
4.6.Shows new ideas in the evaluation of oral anticoagulants. | 10, 11, 16, 19, 6, 9 | A, D, E |
5.4.Explains the relationship between tissue factor and inflammation. | 10, 11, 16, 19, 6, 9 | A, D, E |
6.Can question how coagulation proteins are isolated. | 10, 11, 16, 19, 6, 9 | A, D, E |
6.1.Explains the isolation and clinical use of fibrinogen. | 10, 11, 16, 19, 6, 9 | A, D, E |
6.2.Explains the isolation of prothrombin and its use in the clinic. | 10, 11, 16, 19, 6, 9 | A, D, E |
6.3.Explains the isolation and clinical use of haemophilic factors. | 10, 11, 16, 19, 6, 9 | A, D, E |
6.4.Evaluate the isolation of other coagulation proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
7.Defines the structure and functions of heparin. | 10, 11, 16, 19, 6, 9 | A, D, E |
7.1.Explains the structure and functions of heparin. | 10, 11, 16, 19, 6, 9 | A, D, E |
7.2.Explains the properties of heparin and coagulation relationship. | 10, 11, 16, 19, 6, 9 | A, D, E |
7.3.Shows how the effect of heparin on the coagulation system is measured. | 10, 11, 16, 19, 6, 9 | A, D, E |
7.5.Describes superior techniques in the clinical evaluation of heparin. | 10, 11, 16, 19, 6, 9 | A, D, E |
8.Can question coagulation inhibitors. | 10, 11, 16, 19, 6, 9 | A, D, E |
8.1.Explains protein C and its properties. | 10, 11, 16, 19, 6, 9 | A, D, E |
8.2.Explains the relationship between antithrombin and heparin. | 10, 11, 16, 19, 6, 9 | A, D, E |
8.3.Explains the relationship between heparin and antithrombin. | 10, 11, 16, 19, 6, 9 | A, D, E |
8.4.Evaluates coagulation inhibitors collectively. | 10, 11, 16, 19, 6, 9 | A, D, E |
9.Can question the fibrinolytic system. | 10, 11, 16, 19, 6, 9 | A, D, E |
9.1.Defines the biochemical evaluation of atherosclerotic endothelium. | 10, 11, 16, 19, 6, 9 | A, D, E |
9.2.Explains the relationship between atherosclerosis and platelet. | 10, 11, 16, 19, 6, 9 | A, D, E |
9.3.Explains the coagulation system of atherosclerosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
10-Can question the haemostatic aspect of atherosclerosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
10.1.Explains the relationship between plasminogen and plasmin. | 10, 11, 16, 19, 6, 9 | A, D, E |
10.2.Defines plasminogen and plasmin inhibitors. | 10, 11, 16, 19, 6, 9 | A, D, E |
10.3.Evaluates thrombus in terms of fibrinolytic. | 10, 11, 16, 19, 6, 9 | A, D, E |
10.4.Evaluates the fibrinolytic system in the laboratory. Identify new ideas and applications. | 10, 11, 16, 19, 6, 9 | A, D, E |
11-Analyses printed and electronic resources in the field of haemostasis. | 10, 11, 16, 19, 6, 9 | A, D, E |
12-Take responsibility in management activities, evaluate the processes related to haemostasis in terms of quality. | 10, 11, 16, 19, 6, 9 | A, D, E |
2. Discuss the results of endothelial damage | 10, 11, 16, 19, 6, 9 | A, D, E |
2.3. Defines the aggregation of platelets and explains the pathology. | 10, 11, 16, 19, 6, 9 | A, D, E |
2.5. Identifies new methods to prevent thrombus formation. | 10, 11, 16, 19, 6, 9 | A, D, E |
3.2. It shows how platelet secretion is measured. | 10, 11, 16, 19, 6, 9 | A, D, E |
3.3. Shows how platelet aggregation is measured. | 10, 11, 16, 19, 6, 9 | A, D, E |
5. Question the importance and properties of tissue factor. | 10, 11, 16, 19, 6, 9 | A, D, E |
5.1. Explains the molecular structure and location of the tissue factor. | 10, 11, 16, 19, 6, 9 | A, D, E |
5.2. Evaluates the cause of tissue factor localisation in the body. | 10, 11, 16, 19, 6, 9 | A, D, E |
5.3. Explains the relation of tissue factor and cancer. | 10, 11, 16, 19, 6, 9 | A, D, E |
5.5. Evaluates the importance and properties of tissue factor inhibitor. | 10, 11, 16, 19, 6, 9 | A, D, E |
5.6. To be able to develop new ideas about the relationship between tissue factor and haemostasis. | 10, 11, 16, 19, 6, 9 | A, D, E |
7.4. Evaluates other effects of heparin. | 10, 11, 16, 19, 6, 9 | A, D, E |
9.4. To be able to comprehend atherosclerosis collectively in terms of haemostatic aspects and develop new methods in clinical practice. | 10, 11, 16, 19, 6, 9 | A, D, E |
Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
Order | Subjects | Preliminary Work |
---|---|---|
1 | Biochemical properties of endothelium (II) | 1, 2, 3 |
2 | Platelet metabolism and function (II) | 1, 2, 3 |
3 | Measurement of platelet functions (II) | 1, 2, 3 |
4 | Coagulation proteins | 1, 2, 3 |
5 | Laboratory tests about coagulation proteins | 1, 2, 3 |
6 | Oral anticoagulants | 1, 2, 3 |
7 | Tissue factor and tissue factor pathway inhibitors (II) | 1, 2, 3 |
8 | Isolation of coagulation proteins (I) | 1, 2, 3 |
9 | Isolation of coagulation proteins (II) | 1, 2, 3 |
10 | Heparin structure and function in hemostatic system | 1, 2, 3 |
11 | Structure and function of protein C (II) | 1, 2, 3 |
12 | General basis of coagulation inhibitors | 1, 2, 3 |
13 | Fibrinolytic system | 1, 2, 3 |
14 | Atherosclerosis in aspect of hemostasis | 1, 2, 3 |
Resources |
1)Biochemistry of Haemostatic system in Basic and Applied Biochemistry, Nesrin Emekli 2)Nobel Tıp Kitapevleri, Williams Haematology Beutler, Lichtman, Coller, Kipps ve Seligsohn |
Course Contribution to Program Qualifications
Course Contribution to Program Qualifications | |||||||
No | Program Qualification | Contribution Level | |||||
1 | 2 | 3 | 4 | 5 | |||
1 | Defines macro and micromolecules in cell and body fluids at an advanced level. | X | |||||
2 | Knows how to store and protect the material to be analyzed. | X | |||||
3 | Knows how to identify molecules found in cells and body fluids. | X | |||||
4 | Knows the principles of technologies to be used for routine and research purposes. | X | |||||
5 | Knows how to evaluate the results of the study, interprets and questions. | X | |||||
6 | Knows how to use field-specific tools and equipment | X | |||||
7 | Knows how to access and interpret field-specific resources and information | X | |||||
8 | Shares information with disciplines related to the field | X | |||||
9 | Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals. | X | |||||
10 | Solves a scientific and technical problem, knows where to get help. | X | |||||
11 | Takes responsibility in joint scientific studies, contributes and works in harmony. | X | |||||
12 | Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field. | X | |||||
13 | Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially. | X | |||||
14 | Can take part in management activities, evaluate the results obtained to improve quality | X |
Assessment Methods
Contribution Level | Absolute Evaluation | |
Rate of Midterm Exam to Success | 50 | |
Rate of Final Exam to Success | 50 | |
Total | 100 |
ECTS / Workload Table | ||||||
Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
Course Hours | 14 | 2 | 28 | |||
Guided Problem Solving | 14 | 2 | 28 | |||
Resolution of Homework Problems and Submission as a Report | 6 | 10 | 60 | |||
Term Project | 5 | 10 | 50 | |||
Presentation of Project / Seminar | 2 | 2 | 4 | |||
Quiz | 0 | 0 | 0 | |||
Midterm Exam | 1 | 35 | 35 | |||
General Exam | 1 | 45 | 45 | |||
Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
Total Workload(Hour) | 250 | |||||
Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(250/30) | 8 | |||||
ECTS of the course: 30 hours of work is counted as 1 ECTS credit. |
Detail Informations of the Course
Course Description
Course | Code | Semester | T+P (Hour) | Credit | ECTS |
---|---|---|---|---|---|
HEMOSTASIS BIOCHEMISTRY II | - | Fall Semester | 2+2 | 3 | 8 |
Course Program |
Prerequisites Courses | |
Recommended Elective Courses |
Language of Course | Turkish |
Course Level | Third Cycle (Doctorate Degree) |
Course Type | Elective |
Course Coordinator | |
Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER |
Assistant(s) | |
Aim | Understand biochemical reaction during bleeding and thrombosis, discuss the relation of the clinics with the hemostatic system |
Course Content | This course contains; Biochemical properties of endothelium (II),Platelet metabolism and function (II),Measurement of platelet functions (II),Coagulation proteins,Laboratory tests about coagulation proteins,Oral anticoagulants,Tissue factor and tissue factor pathway inhibitors (II),Isolation of coagulation proteins (I),Isolation of coagulation proteins (II),Heparin structure and function in hemostatic system,Structure and function of protein C (II),General basis of coagulation inhibitors,Fibrinolytic system,Atherosclerosis in aspect of hemostasis. |
Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
1-At the end of this course, the students will be able to; | 10, 11, 16, 19, 6, 9 | A, D, E |
1.1Understands what endothelial damage is and evaluates the results. | 10, 11, 16, 19, 6, 9 | A, D, E |
1.2.Defines what haemostatic factors are found in the subendothelium. | 10, 11, 16, 19, 6, 9 | A, D, E |
1.3.Explain the functions of proteins released from the endothelium. | 10, 11, 16, 19, 6, 9 | A, D, E |
1.4.It questions why blood circulates in the vein without clotting. | 10, 11, 16, 19, 6, 9 | A, D, E |
2.1.Explain the adhesion of platelets and evaluate the pathology. | 10, 11, 16, 19, 6, 9 | A, D, E |
2.2.Definitions platelet secretion and explains the pathology. | 10, 11, 16, 19, 6, 9 | A, D, E |
2.4.Evaluates platelet function in thrombus-prone conditions. | 10, 11, 16, 19, 6, 9 | A, D, E |
3-Evaluate overview of thrombosis in biochemical aspects | 10, 11, 16, 19, 6, 9 | A, D, E |
3.1.Explain how platelet adhesion is measured. | 10, 11, 16, 19, 6, 9 | A, D, E |
3.4.Explains the relationship between antiaggregant platelet. | 10, 11, 16, 19, 6, 9 | A, D, E |
4-Discuss the properties and measurement of coagulation proteins in the blood | 10, 11, 16, 19, 6, 9 | A, D, E |
4.Learn the properties and measurement of contact activation factor | 10, 11, 16, 19, 6, 9 | A, D, E |
4.1.Explain the importance of contact activation proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
4.2.Explain the difference between extrinsic system and intrinsic system proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
4.3.Explains the proteins in the common pathway and the activity of platelets. | 10, 11, 16, 19, 6, 9 | A, D, E |
4.4.Develops ideas related to the balancing of thrombin and fibrin in pathological conditions. | 10, 11, 16, 19, 6, 9 | A, D, E |
4.5.Explains the relationship between oral anticoagulants and coagulation. | 10, 11, 16, 19, 6, 9 | A, D, E |
4.6.Shows new ideas in the evaluation of oral anticoagulants. | 10, 11, 16, 19, 6, 9 | A, D, E |
5.4.Explains the relationship between tissue factor and inflammation. | 10, 11, 16, 19, 6, 9 | A, D, E |
6.Can question how coagulation proteins are isolated. | 10, 11, 16, 19, 6, 9 | A, D, E |
6.1.Explains the isolation and clinical use of fibrinogen. | 10, 11, 16, 19, 6, 9 | A, D, E |
6.2.Explains the isolation of prothrombin and its use in the clinic. | 10, 11, 16, 19, 6, 9 | A, D, E |
6.3.Explains the isolation and clinical use of haemophilic factors. | 10, 11, 16, 19, 6, 9 | A, D, E |
6.4.Evaluate the isolation of other coagulation proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
7.Defines the structure and functions of heparin. | 10, 11, 16, 19, 6, 9 | A, D, E |
7.1.Explains the structure and functions of heparin. | 10, 11, 16, 19, 6, 9 | A, D, E |
7.2.Explains the properties of heparin and coagulation relationship. | 10, 11, 16, 19, 6, 9 | A, D, E |
7.3.Shows how the effect of heparin on the coagulation system is measured. | 10, 11, 16, 19, 6, 9 | A, D, E |
7.5.Describes superior techniques in the clinical evaluation of heparin. | 10, 11, 16, 19, 6, 9 | A, D, E |
8.Can question coagulation inhibitors. | 10, 11, 16, 19, 6, 9 | A, D, E |
8.1.Explains protein C and its properties. | 10, 11, 16, 19, 6, 9 | A, D, E |
8.2.Explains the relationship between antithrombin and heparin. | 10, 11, 16, 19, 6, 9 | A, D, E |
8.3.Explains the relationship between heparin and antithrombin. | 10, 11, 16, 19, 6, 9 | A, D, E |
8.4.Evaluates coagulation inhibitors collectively. | 10, 11, 16, 19, 6, 9 | A, D, E |
9.Can question the fibrinolytic system. | 10, 11, 16, 19, 6, 9 | A, D, E |
9.1.Defines the biochemical evaluation of atherosclerotic endothelium. | 10, 11, 16, 19, 6, 9 | A, D, E |
9.2.Explains the relationship between atherosclerosis and platelet. | 10, 11, 16, 19, 6, 9 | A, D, E |
9.3.Explains the coagulation system of atherosclerosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
10-Can question the haemostatic aspect of atherosclerosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
10.1.Explains the relationship between plasminogen and plasmin. | 10, 11, 16, 19, 6, 9 | A, D, E |
10.2.Defines plasminogen and plasmin inhibitors. | 10, 11, 16, 19, 6, 9 | A, D, E |
10.3.Evaluates thrombus in terms of fibrinolytic. | 10, 11, 16, 19, 6, 9 | A, D, E |
10.4.Evaluates the fibrinolytic system in the laboratory. Identify new ideas and applications. | 10, 11, 16, 19, 6, 9 | A, D, E |
11-Analyses printed and electronic resources in the field of haemostasis. | 10, 11, 16, 19, 6, 9 | A, D, E |
12-Take responsibility in management activities, evaluate the processes related to haemostasis in terms of quality. | 10, 11, 16, 19, 6, 9 | A, D, E |
2. Discuss the results of endothelial damage | 10, 11, 16, 19, 6, 9 | A, D, E |
2.3. Defines the aggregation of platelets and explains the pathology. | 10, 11, 16, 19, 6, 9 | A, D, E |
2.5. Identifies new methods to prevent thrombus formation. | 10, 11, 16, 19, 6, 9 | A, D, E |
3.2. It shows how platelet secretion is measured. | 10, 11, 16, 19, 6, 9 | A, D, E |
3.3. Shows how platelet aggregation is measured. | 10, 11, 16, 19, 6, 9 | A, D, E |
5. Question the importance and properties of tissue factor. | 10, 11, 16, 19, 6, 9 | A, D, E |
5.1. Explains the molecular structure and location of the tissue factor. | 10, 11, 16, 19, 6, 9 | A, D, E |
5.2. Evaluates the cause of tissue factor localisation in the body. | 10, 11, 16, 19, 6, 9 | A, D, E |
5.3. Explains the relation of tissue factor and cancer. | 10, 11, 16, 19, 6, 9 | A, D, E |
5.5. Evaluates the importance and properties of tissue factor inhibitor. | 10, 11, 16, 19, 6, 9 | A, D, E |
5.6. To be able to develop new ideas about the relationship between tissue factor and haemostasis. | 10, 11, 16, 19, 6, 9 | A, D, E |
7.4. Evaluates other effects of heparin. | 10, 11, 16, 19, 6, 9 | A, D, E |
9.4. To be able to comprehend atherosclerosis collectively in terms of haemostatic aspects and develop new methods in clinical practice. | 10, 11, 16, 19, 6, 9 | A, D, E |
Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
Order | Subjects | Preliminary Work |
---|---|---|
1 | Biochemical properties of endothelium (II) | 1, 2, 3 |
2 | Platelet metabolism and function (II) | 1, 2, 3 |
3 | Measurement of platelet functions (II) | 1, 2, 3 |
4 | Coagulation proteins | 1, 2, 3 |
5 | Laboratory tests about coagulation proteins | 1, 2, 3 |
6 | Oral anticoagulants | 1, 2, 3 |
7 | Tissue factor and tissue factor pathway inhibitors (II) | 1, 2, 3 |
8 | Isolation of coagulation proteins (I) | 1, 2, 3 |
9 | Isolation of coagulation proteins (II) | 1, 2, 3 |
10 | Heparin structure and function in hemostatic system | 1, 2, 3 |
11 | Structure and function of protein C (II) | 1, 2, 3 |
12 | General basis of coagulation inhibitors | 1, 2, 3 |
13 | Fibrinolytic system | 1, 2, 3 |
14 | Atherosclerosis in aspect of hemostasis | 1, 2, 3 |
Resources |
1)Biochemistry of Haemostatic system in Basic and Applied Biochemistry, Nesrin Emekli 2)Nobel Tıp Kitapevleri, Williams Haematology Beutler, Lichtman, Coller, Kipps ve Seligsohn |
Course Contribution to Program Qualifications
Course Contribution to Program Qualifications | |||||||
No | Program Qualification | Contribution Level | |||||
1 | 2 | 3 | 4 | 5 | |||
1 | Defines macro and micromolecules in cell and body fluids at an advanced level. | X | |||||
2 | Knows how to store and protect the material to be analyzed. | X | |||||
3 | Knows how to identify molecules found in cells and body fluids. | X | |||||
4 | Knows the principles of technologies to be used for routine and research purposes. | X | |||||
5 | Knows how to evaluate the results of the study, interprets and questions. | X | |||||
6 | Knows how to use field-specific tools and equipment | X | |||||
7 | Knows how to access and interpret field-specific resources and information | X | |||||
8 | Shares information with disciplines related to the field | X | |||||
9 | Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals. | X | |||||
10 | Solves a scientific and technical problem, knows where to get help. | X | |||||
11 | Takes responsibility in joint scientific studies, contributes and works in harmony. | X | |||||
12 | Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field. | X | |||||
13 | Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially. | X | |||||
14 | Can take part in management activities, evaluate the results obtained to improve quality | X |
Assessment Methods
Contribution Level | Absolute Evaluation | |
Rate of Midterm Exam to Success | 50 | |
Rate of Final Exam to Success | 50 | |
Total | 100 |