Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| MOLECULAR GENETICS | - | Fall Semester | 4+0 | 4 | 7 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | Assist.Prof. Salih GENCER |
| Name of Lecturer(s) | Prof.Dr. Gürkan ÖZTÜRK, Prof.Dr. Cafer MARANGOZ, Prof.Dr. Zübeyir BAYRAKTAROĞLU, Assoc.Prof. Sultan Sibel ERDEM, Assoc.Prof. Ayşe Arzu ŞAKUL, Prof.Dr. İlknur KESKİN, Prof.Dr. Esra ÇAĞAVİ, Prof.Dr. Mustafa GÜZEL, Assoc.Prof. Nihal KARAKAŞ, Assist.Prof. Elif Zeynep YILMAZ, Assist.Prof. Salih GENCER |
| Assistant(s) | |
| Aim | To learn the cell membrane, endomembrane system, organelles and clinical importance of these systems. Understanding of endocytosis, exocytosis, intracellular skeletal system. To know the basics of cell cycle, cell division and cell aging. To learn DNA replication, nucleic acids, DNA and structure of DNA. Understanding of transcription and translation steps of gene expression and epigenetic control of gene expression. To understand the causes and repair mechanisms of DNA damage and to know the basics of cancer biology and genetics. To learn immunobiology and stem cell biology. To gain insights on the methods used in molecular biology. Understanding of chromosomal anomalies with mendel and nonmendel inheritance models and their importance in clinical genetics. |
| Course Content | This course contains; Cell membrane, endomembrane system, organelles and clinical relevance,Cell membrane, endomembrane system, organelles and clinical relevance,Directed protein synthesis, Endocytosis-exocytosis, receptor-mediated endocytosis,Cytoskeleton, cell junctions and extracellular matrix,Cell cycle, cell senescence and cell death,Nucleic acids, DNA structure and replication,Transcription and protein synthesis,DNA damage and repair,Cancer biology and cancer genetics,Immunobiology and stem cell biology,Epigenetics,The methods used in molecular biology and molecular genetics ,Mendelian and Nonmendelian inheritance and chromosomal anomalies,Clinical genetics. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1. Defines the concepts of molecular biology and genetics underlying cell functioning. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1 Defines the structure and functions of the molecules that make up the cell. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2 Compares the synthesis and degradation of cellular molecules. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3 Summarizes molecular biology techniques used in the study of molecules and structures that enable the cell to function. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2. Interprets cell functioning and intercellular communication mechanisms. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1 Defines the compartments (organelles) that make up the cell. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2 Explains the structure and functions of organelles within the cell. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3 Explains the molecular transport and communication mechanisms between cellular organelles. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4 Explains intercellular communication mechanisms and signal perception. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.5 Questions the molecular origins of diseases caused by disruption of cellular functioning. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3. Discuss the functioning and structuring of cells in the organism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1 Explains tissue and organ development from cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2 Explains the genetic and molecular mechanisms that affect cells forming the organism. | 11, 16, 19, 6, 9 | A, D, E |
| 3.3 Defines the structure-function relationship in cells and organisms. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4 Discusses the genetic origins of diseases that prevent the healthy functioning of cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Cell membrane, endomembrane system, organelles and clinical relevance | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 2 | Cell membrane, endomembrane system, organelles and clinical relevance | Molecula rCell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 3 | Directed protein synthesis, Endocytosis-exocytosis, receptor-mediated endocytosis | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 4 | Cytoskeleton, cell junctions and extracellular matrix | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 5 | Cell cycle, cell senescence and cell death | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 6 | Nucleic acids, DNA structure and replication | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 7 | Transcription and protein synthesis | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 8 | DNA damage and repair | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 9 | Cancer biology and cancer genetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 10 | Immunobiology and stem cell biology | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 11 | Epigenetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 12 | The methods used in molecular biology and molecular genetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 13 | Mendelian and Nonmendelian inheritance and chromosomal anomalies | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 14 | Clinical genetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| Resources |
| Cell Biology Essential Cell Biology Molecular Biology of the Cell |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Has the essential knowledge about the structure and functioning of the nervous system. | X | |||||
| 2 | Knows the essential scientific questions of neuroscience and current fields of research. | X | |||||
| 3 | Have knowledge and interpretation skills about neurodegenerative processes. | X | |||||
| 4 | Know the principles of technologies for the measurement of molecular and cellular level parameters. | X | |||||
| 5 | Able to comment on related scientific researches with respect to rational, method and results. | X | |||||
| 6 | Knows main laboratory techniques. | X | |||||
| 7 | Able to explain main scientific questions regarding neuroscience. | X | |||||
| 8 | Able to evaluate all new information regarding the field and associate them based on available knowledge. | X | |||||
| 9 | Uses the communication and computer technology effectively in theoretical and practical studies. | X | |||||
| 10 | Able to present theoretical or research data orally or written in Turkish as well in English languages. | X | |||||
| 11 | Adheres to ethical values and behaves according to dynamics of social responsibility. | X | |||||
| 12 | Behaves in accordance with the principle that neuroscience research should eventually aim clinical implications and benefit. | X | |||||
| 13 | Able to participate neuroscience research teams; individually undertake the responsibility of the work assigned and perform it independently. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 4 | 56 | |||
| Guided Problem Solving | 14 | 8 | 112 | |||
| Resolution of Homework Problems and Submission as a Report | 0 | 0 | 0 | |||
| Term Project | 0 | 0 | 0 | |||
| Presentation of Project / Seminar | 0 | 0 | 0 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 15 | 15 | |||
| General Exam | 1 | 27 | 27 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 210 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(210/30) | 7 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| MOLECULAR GENETICS | - | Fall Semester | 4+0 | 4 | 7 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | Assist.Prof. Salih GENCER |
| Name of Lecturer(s) | Prof.Dr. Gürkan ÖZTÜRK, Prof.Dr. Cafer MARANGOZ, Prof.Dr. Zübeyir BAYRAKTAROĞLU, Assoc.Prof. Sultan Sibel ERDEM, Assoc.Prof. Ayşe Arzu ŞAKUL, Prof.Dr. İlknur KESKİN, Prof.Dr. Esra ÇAĞAVİ, Prof.Dr. Mustafa GÜZEL, Assoc.Prof. Nihal KARAKAŞ, Assist.Prof. Elif Zeynep YILMAZ, Assist.Prof. Salih GENCER |
| Assistant(s) | |
| Aim | To learn the cell membrane, endomembrane system, organelles and clinical importance of these systems. Understanding of endocytosis, exocytosis, intracellular skeletal system. To know the basics of cell cycle, cell division and cell aging. To learn DNA replication, nucleic acids, DNA and structure of DNA. Understanding of transcription and translation steps of gene expression and epigenetic control of gene expression. To understand the causes and repair mechanisms of DNA damage and to know the basics of cancer biology and genetics. To learn immunobiology and stem cell biology. To gain insights on the methods used in molecular biology. Understanding of chromosomal anomalies with mendel and nonmendel inheritance models and their importance in clinical genetics. |
| Course Content | This course contains; Cell membrane, endomembrane system, organelles and clinical relevance,Cell membrane, endomembrane system, organelles and clinical relevance,Directed protein synthesis, Endocytosis-exocytosis, receptor-mediated endocytosis,Cytoskeleton, cell junctions and extracellular matrix,Cell cycle, cell senescence and cell death,Nucleic acids, DNA structure and replication,Transcription and protein synthesis,DNA damage and repair,Cancer biology and cancer genetics,Immunobiology and stem cell biology,Epigenetics,The methods used in molecular biology and molecular genetics ,Mendelian and Nonmendelian inheritance and chromosomal anomalies,Clinical genetics. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1. Defines the concepts of molecular biology and genetics underlying cell functioning. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1 Defines the structure and functions of the molecules that make up the cell. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2 Compares the synthesis and degradation of cellular molecules. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3 Summarizes molecular biology techniques used in the study of molecules and structures that enable the cell to function. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2. Interprets cell functioning and intercellular communication mechanisms. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1 Defines the compartments (organelles) that make up the cell. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2 Explains the structure and functions of organelles within the cell. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3 Explains the molecular transport and communication mechanisms between cellular organelles. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4 Explains intercellular communication mechanisms and signal perception. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.5 Questions the molecular origins of diseases caused by disruption of cellular functioning. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3. Discuss the functioning and structuring of cells in the organism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1 Explains tissue and organ development from cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2 Explains the genetic and molecular mechanisms that affect cells forming the organism. | 11, 16, 19, 6, 9 | A, D, E |
| 3.3 Defines the structure-function relationship in cells and organisms. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4 Discusses the genetic origins of diseases that prevent the healthy functioning of cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Cell membrane, endomembrane system, organelles and clinical relevance | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 2 | Cell membrane, endomembrane system, organelles and clinical relevance | Molecula rCell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 3 | Directed protein synthesis, Endocytosis-exocytosis, receptor-mediated endocytosis | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 4 | Cytoskeleton, cell junctions and extracellular matrix | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 5 | Cell cycle, cell senescence and cell death | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 6 | Nucleic acids, DNA structure and replication | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 7 | Transcription and protein synthesis | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 8 | DNA damage and repair | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 9 | Cancer biology and cancer genetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 10 | Immunobiology and stem cell biology | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 11 | Epigenetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 12 | The methods used in molecular biology and molecular genetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 13 | Mendelian and Nonmendelian inheritance and chromosomal anomalies | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 14 | Clinical genetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| Resources |
| Cell Biology Essential Cell Biology Molecular Biology of the Cell |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Has the essential knowledge about the structure and functioning of the nervous system. | X | |||||
| 2 | Knows the essential scientific questions of neuroscience and current fields of research. | X | |||||
| 3 | Have knowledge and interpretation skills about neurodegenerative processes. | X | |||||
| 4 | Know the principles of technologies for the measurement of molecular and cellular level parameters. | X | |||||
| 5 | Able to comment on related scientific researches with respect to rational, method and results. | X | |||||
| 6 | Knows main laboratory techniques. | X | |||||
| 7 | Able to explain main scientific questions regarding neuroscience. | X | |||||
| 8 | Able to evaluate all new information regarding the field and associate them based on available knowledge. | X | |||||
| 9 | Uses the communication and computer technology effectively in theoretical and practical studies. | X | |||||
| 10 | Able to present theoretical or research data orally or written in Turkish as well in English languages. | X | |||||
| 11 | Adheres to ethical values and behaves according to dynamics of social responsibility. | X | |||||
| 12 | Behaves in accordance with the principle that neuroscience research should eventually aim clinical implications and benefit. | X | |||||
| 13 | Able to participate neuroscience research teams; individually undertake the responsibility of the work assigned and perform it independently. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |