Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| MOLECULAR GENETICS | - | Fall Semester | 4+0 | 4 | 7 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | Assist.Prof. Salih GENCER |
| Name of Lecturer(s) | Prof.Dr. Gürkan ÖZTÜRK, Prof.Dr. Cafer MARANGOZ, Prof.Dr. Zübeyir BAYRAKTAROĞLU, Assoc.Prof. Sultan Sibel ERDEM, Assoc.Prof. Ayşe Arzu ŞAKUL, Prof.Dr. İlknur KESKİN, Prof.Dr. Mustafa GÜZEL, Prof.Dr. Esra ÇAĞAVİ, Assoc.Prof. Nihal KARAKAŞ, Assist.Prof. Elif Zeynep YILMAZ, Assist.Prof. Salih GENCER |
| Assistant(s) | |
| Aim | To learn the cell membrane, endomembrane system, organelles and clinical importance of these systems. Understanding of endocytosis, exocytosis, intracellular skeletal system. To know the basics of cell cycle, cell division and cell aging. To learn DNA replication, nucleic acids, DNA and structure of DNA. Understanding of transcription and translation steps of gene expression and epigenetic control of gene expression. To understand the causes and repair mechanisms of DNA damage and to know the basics of cancer biology and genetics. To learn immunobiology and stem cell biology. To gain insights on the methods used in molecular biology. Understanding of chromosomal anomalies with mendel and nonmendel inheritance models and their importance in clinical genetics. |
| Course Content | This course contains; Cell membrane, endomembrane system, organelles and clinical relevance,Cell membrane, endomembrane system, organelles and clinical relevance,Directed protein synthesis, Endocytosis-exocytosis, receptor-mediated endocytosis,Cytoskeleton, cell junctions and extracellular matrix,Cell cycle, cell senescence and cell death,Nucleic acids, DNA structure and replication,Transcription and protein synthesis,DNA damage and repair,Cancer biology and cancer genetics,Immunobiology and stem cell biology,Epigenetics,The methods used in molecular biology and molecular genetics ,Mendelian and Nonmendelian inheritance and chromosomal anomalies,Clinical genetics. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1. Defines the concepts of molecular biology and genetics underlying cell functioning. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1 Defines the structure and functions of the molecules that make up the cell. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2 Compares the synthesis and degradation of cellular molecules. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3 Summarizes molecular biology techniques used in the study of molecules and structures that enable the cell to function. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2. Interprets cell functioning and intercellular communication mechanisms. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1 Defines the compartments (organelles) that make up the cell. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2 Explains the structure and functions of organelles within the cell. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3 Explains the molecular transport and communication mechanisms between cellular organelles. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4 Explains intercellular communication mechanisms and signal perception. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.5 Questions the molecular origins of diseases caused by disruption of cellular functioning. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3. Discuss the functioning and structuring of cells in the organism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1 Explains tissue and organ development from cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2 Explains the genetic and molecular mechanisms that affect cells forming the organism. | 11, 16, 19, 6, 9 | A, D, E |
| 3.3 Defines the structure-function relationship in cells and organisms. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4 Discusses the genetic origins of diseases that prevent the healthy functioning of cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Cell membrane, endomembrane system, organelles and clinical relevance | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 2 | Cell membrane, endomembrane system, organelles and clinical relevance | Molecula rCell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 3 | Directed protein synthesis, Endocytosis-exocytosis, receptor-mediated endocytosis | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 4 | Cytoskeleton, cell junctions and extracellular matrix | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 5 | Cell cycle, cell senescence and cell death | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 6 | Nucleic acids, DNA structure and replication | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 7 | Transcription and protein synthesis | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 8 | DNA damage and repair | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 9 | Cancer biology and cancer genetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 10 | Immunobiology and stem cell biology | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 11 | Epigenetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 12 | The methods used in molecular biology and molecular genetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 13 | Mendelian and Nonmendelian inheritance and chromosomal anomalies | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 14 | Clinical genetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| Resources |
| Cell Biology Essential Cell Biology Molecular Biology of the Cell |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Gains up-to-date scientific knowledge and skills in the field of microbiology and follows the innovations in this field. | ||||||
| 2 | Plans and statistically assesses scientific research, prepares an article for publication in a refereed journal and/or presents it in a scientific meeting. | ||||||
| 3 | Uses microbiology laboratories in accordance with good laboratory practices and biosafety rules. | ||||||
| 4 | Cognizant of the importance of interdisciplinary studies and follows the disciplines related to the field. | ||||||
| 5 | Develops ability to use of devices and tools that serve routine and research purposes in the basic microbiology laboratory and applies a research in the laboratory. | ||||||
| 6 | Knows how to use scientific resources in the library and/or on the internet to reach scientific information. | ||||||
| 7 | Develops the ability to present scientific study results or a topic in the field at a professional level. | ||||||
| 8 | Develops critical and analytical thinking skills by using theoretical knowledge, the ability to listen carefully and ask the right questions. | ||||||
| 9 | Defines a scientific or technical problem under supervision or rather independently, develops a plan of action to address the problem. | ||||||
| 10 | Monitors the current, national and international professional literature in the field of microbiology, presents topic of interest as a seminar or publishes the rsults in a journal. | ||||||
| 11 | Appreciates and internalizes the social, scientific, cultural and ethical values in the stages of collecting, interpreting, applying and announcing data related to the field of microbiology. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 4 | 56 | |||
| Guided Problem Solving | 14 | 8 | 112 | |||
| Resolution of Homework Problems and Submission as a Report | 0 | 0 | 0 | |||
| Term Project | 0 | 0 | 0 | |||
| Presentation of Project / Seminar | 0 | 0 | 0 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 15 | 15 | |||
| General Exam | 1 | 27 | 27 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 210 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(210/30) | 7 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| MOLECULAR GENETICS | - | Fall Semester | 4+0 | 4 | 7 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | Assist.Prof. Salih GENCER |
| Name of Lecturer(s) | Prof.Dr. Gürkan ÖZTÜRK, Prof.Dr. Cafer MARANGOZ, Prof.Dr. Zübeyir BAYRAKTAROĞLU, Assoc.Prof. Sultan Sibel ERDEM, Assoc.Prof. Ayşe Arzu ŞAKUL, Prof.Dr. İlknur KESKİN, Prof.Dr. Mustafa GÜZEL, Prof.Dr. Esra ÇAĞAVİ, Assoc.Prof. Nihal KARAKAŞ, Assist.Prof. Elif Zeynep YILMAZ, Assist.Prof. Salih GENCER |
| Assistant(s) | |
| Aim | To learn the cell membrane, endomembrane system, organelles and clinical importance of these systems. Understanding of endocytosis, exocytosis, intracellular skeletal system. To know the basics of cell cycle, cell division and cell aging. To learn DNA replication, nucleic acids, DNA and structure of DNA. Understanding of transcription and translation steps of gene expression and epigenetic control of gene expression. To understand the causes and repair mechanisms of DNA damage and to know the basics of cancer biology and genetics. To learn immunobiology and stem cell biology. To gain insights on the methods used in molecular biology. Understanding of chromosomal anomalies with mendel and nonmendel inheritance models and their importance in clinical genetics. |
| Course Content | This course contains; Cell membrane, endomembrane system, organelles and clinical relevance,Cell membrane, endomembrane system, organelles and clinical relevance,Directed protein synthesis, Endocytosis-exocytosis, receptor-mediated endocytosis,Cytoskeleton, cell junctions and extracellular matrix,Cell cycle, cell senescence and cell death,Nucleic acids, DNA structure and replication,Transcription and protein synthesis,DNA damage and repair,Cancer biology and cancer genetics,Immunobiology and stem cell biology,Epigenetics,The methods used in molecular biology and molecular genetics ,Mendelian and Nonmendelian inheritance and chromosomal anomalies,Clinical genetics. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1. Defines the concepts of molecular biology and genetics underlying cell functioning. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1 Defines the structure and functions of the molecules that make up the cell. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2 Compares the synthesis and degradation of cellular molecules. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3 Summarizes molecular biology techniques used in the study of molecules and structures that enable the cell to function. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2. Interprets cell functioning and intercellular communication mechanisms. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1 Defines the compartments (organelles) that make up the cell. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2 Explains the structure and functions of organelles within the cell. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3 Explains the molecular transport and communication mechanisms between cellular organelles. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4 Explains intercellular communication mechanisms and signal perception. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.5 Questions the molecular origins of diseases caused by disruption of cellular functioning. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3. Discuss the functioning and structuring of cells in the organism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1 Explains tissue and organ development from cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2 Explains the genetic and molecular mechanisms that affect cells forming the organism. | 11, 16, 19, 6, 9 | A, D, E |
| 3.3 Defines the structure-function relationship in cells and organisms. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4 Discusses the genetic origins of diseases that prevent the healthy functioning of cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Cell membrane, endomembrane system, organelles and clinical relevance | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 2 | Cell membrane, endomembrane system, organelles and clinical relevance | Molecula rCell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 3 | Directed protein synthesis, Endocytosis-exocytosis, receptor-mediated endocytosis | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 4 | Cytoskeleton, cell junctions and extracellular matrix | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 5 | Cell cycle, cell senescence and cell death | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 6 | Nucleic acids, DNA structure and replication | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 7 | Transcription and protein synthesis | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 8 | DNA damage and repair | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 9 | Cancer biology and cancer genetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 10 | Immunobiology and stem cell biology | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 11 | Epigenetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 12 | The methods used in molecular biology and molecular genetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 13 | Mendelian and Nonmendelian inheritance and chromosomal anomalies | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| 14 | Clinical genetics | Molecular Cell Biology 9th ed. (Arnold Berk , Chris A. Kaiser , Harvey Lodish , Monty Krieger) |
| Resources |
| Cell Biology Essential Cell Biology Molecular Biology of the Cell |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Gains up-to-date scientific knowledge and skills in the field of microbiology and follows the innovations in this field. | ||||||
| 2 | Plans and statistically assesses scientific research, prepares an article for publication in a refereed journal and/or presents it in a scientific meeting. | ||||||
| 3 | Uses microbiology laboratories in accordance with good laboratory practices and biosafety rules. | ||||||
| 4 | Cognizant of the importance of interdisciplinary studies and follows the disciplines related to the field. | ||||||
| 5 | Develops ability to use of devices and tools that serve routine and research purposes in the basic microbiology laboratory and applies a research in the laboratory. | ||||||
| 6 | Knows how to use scientific resources in the library and/or on the internet to reach scientific information. | ||||||
| 7 | Develops the ability to present scientific study results or a topic in the field at a professional level. | ||||||
| 8 | Develops critical and analytical thinking skills by using theoretical knowledge, the ability to listen carefully and ask the right questions. | ||||||
| 9 | Defines a scientific or technical problem under supervision or rather independently, develops a plan of action to address the problem. | ||||||
| 10 | Monitors the current, national and international professional literature in the field of microbiology, presents topic of interest as a seminar or publishes the rsults in a journal. | ||||||
| 11 | Appreciates and internalizes the social, scientific, cultural and ethical values in the stages of collecting, interpreting, applying and announcing data related to the field of microbiology. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |