Ders Detayı
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| RADIOBIOLOGY | - | Fall Semester | 4+0 | 4 | 12 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Required |
| Course Coordinator | Assist.Prof. Mustafa ÇAĞLAR |
| Name of Lecturer(s) | |
| Assistant(s) | |
| Aim | To give information about the biological effects of radiation |
| Course Content | This course contains; Review of basic cell biology (nucleus, membrane, cytoplasm, organelle).,History of radiation injuries in humans,Radiation interactions,Indirect effects of radiation,Target theory and cell survival curves,Apoptosis, reproductive cell death,RBE, OER, Radioprotectors, radiosensitizers,Tissue injuries, Acute effects of radiation,Radiation carcinogenesis, Radiation mutagenesis,Risk estimates of radiation, Predictions of cancers in populations,Radiation epidemiology, Evidence of cancers in populations,Concept of radiation hormesis,BED/EQD2 calculations, calculating the effects of treatment delays (Tpot, Tdelay),BED/EQD2 calculations, calculating the effects of treatment delays (Tpot, Tdelay),Tumor radiobiology, Molecular mechanisms, Drug/radiation interactions. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| Explains basic cell biology. | 10, 9 | A |
| Analyses radiation damage types and effect levels. | 19, 9 | A |
| Explain the DNA damage and repair mechanisms of radiation. | 21, 9 | A |
| Defines topics related to radiation damage relationship such as Target Theory, Cell survival curves. | 10, 9 | A |
| Analyses tumour biology, tumour radiobiology and molecular mechanisms. | 19, 9 | A |
| Teaching Methods: | 10: Discussion Method, 19: Brainstorming Technique, 21: Simulation Technique, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Review of basic cell biology (nucleus, membrane, cytoplasm, organelle). | Mebis Lecture Notes |
| 2 | History of radiation injuries in humans | Mebis Lecture Notes |
| 3 | Radiation interactions | Mebis Lecture Notes |
| 4 | Indirect effects of radiation | Mebis Lecture Notes |
| 5 | Target theory and cell survival curves | Mebis Lecture Notes |
| 6 | Apoptosis, reproductive cell death | Mebis Lecture Notes |
| 7 | RBE, OER, Radioprotectors, radiosensitizers | Mebis Lecture Notes |
| 8 | Tissue injuries, Acute effects of radiation | Mebis Lecture Notes |
| 9 | Radiation carcinogenesis, Radiation mutagenesis | Mebis Lecture Notes |
| 10 | Risk estimates of radiation, Predictions of cancers in populations | Mebis Lecture Notes |
| 11 | Radiation epidemiology, Evidence of cancers in populations | Mebis Lecture Notes |
| 12 | Concept of radiation hormesis | Mebis Lecture Notes |
| 13 | BED/EQD2 calculations, calculating the effects of treatment delays (Tpot, Tdelay) | Mebis Lecture Notes |
| 13 | BED/EQD2 calculations, calculating the effects of treatment delays (Tpot, Tdelay) | Mebis Lecture Notes |
| 14 | Tumor radiobiology, Molecular mechanisms, Drug/radiation interactions | Mebis Lecture Notes |
| Resources |
| Basic Radiotherapy Physics and Biology David S. Chang • Foster D. Lasley Indra J. Das • Marc S. Mendonca Joseph R. Dynlacht |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Has the essential knowledge about the structure and functioning of the radiation emitting machines used in radiation oncology, nuclear medicine and radiology. | X | |||||
| 2 | Able to follow and implement daily, weekly and monthly quality control programs of radiation emitting machines. | X | |||||
| 3 | Able to do the acceptance and commissioning of new machines. | X | |||||
| 4 | Able to the treatment planning of patients. | X | |||||
| 5 | Able to be a radiation safety officer of the institute. | X | |||||
| 6 | Able to participate fields research teams; individually undertake the responsibility of the work assigned and perform it independently. | X | |||||
| 7 | Able to evaluate all new information regarding the field and associate them based on available knowledge. | X | |||||
| 8 | Uses the communication and computer technology effectively in theoretical and practical studies. | X | |||||
| 9 | Able to present theoretical or research data orally or written. | X | |||||
| 10 | Adheres to ethical values and behaves according to dynamics of social responsibility. | X | |||||
| 11 | Able to do the planning of clinical implementation without giving harm to staff and patient. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 4 | 56 | |||
| Guided Problem Solving | 2 | 20 | 40 | |||
| Resolution of Homework Problems and Submission as a Report | 2 | 30 | 60 | |||
| Term Project | 0 | 0 | 0 | |||
| Presentation of Project / Seminar | 2 | 60 | 120 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 30 | 30 | |||
| General Exam | 1 | 60 | 60 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 366 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(366/30) | 12 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| RADIOBIOLOGY | - | Fall Semester | 4+0 | 4 | 12 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Required |
| Course Coordinator | Assist.Prof. Mustafa ÇAĞLAR |
| Name of Lecturer(s) | |
| Assistant(s) | |
| Aim | To give information about the biological effects of radiation |
| Course Content | This course contains; Review of basic cell biology (nucleus, membrane, cytoplasm, organelle).,History of radiation injuries in humans,Radiation interactions,Indirect effects of radiation,Target theory and cell survival curves,Apoptosis, reproductive cell death,RBE, OER, Radioprotectors, radiosensitizers,Tissue injuries, Acute effects of radiation,Radiation carcinogenesis, Radiation mutagenesis,Risk estimates of radiation, Predictions of cancers in populations,Radiation epidemiology, Evidence of cancers in populations,Concept of radiation hormesis,BED/EQD2 calculations, calculating the effects of treatment delays (Tpot, Tdelay),BED/EQD2 calculations, calculating the effects of treatment delays (Tpot, Tdelay),Tumor radiobiology, Molecular mechanisms, Drug/radiation interactions. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| Explains basic cell biology. | 10, 9 | A |
| Analyses radiation damage types and effect levels. | 19, 9 | A |
| Explain the DNA damage and repair mechanisms of radiation. | 21, 9 | A |
| Defines topics related to radiation damage relationship such as Target Theory, Cell survival curves. | 10, 9 | A |
| Analyses tumour biology, tumour radiobiology and molecular mechanisms. | 19, 9 | A |
| Teaching Methods: | 10: Discussion Method, 19: Brainstorming Technique, 21: Simulation Technique, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Review of basic cell biology (nucleus, membrane, cytoplasm, organelle). | Mebis Lecture Notes |
| 2 | History of radiation injuries in humans | Mebis Lecture Notes |
| 3 | Radiation interactions | Mebis Lecture Notes |
| 4 | Indirect effects of radiation | Mebis Lecture Notes |
| 5 | Target theory and cell survival curves | Mebis Lecture Notes |
| 6 | Apoptosis, reproductive cell death | Mebis Lecture Notes |
| 7 | RBE, OER, Radioprotectors, radiosensitizers | Mebis Lecture Notes |
| 8 | Tissue injuries, Acute effects of radiation | Mebis Lecture Notes |
| 9 | Radiation carcinogenesis, Radiation mutagenesis | Mebis Lecture Notes |
| 10 | Risk estimates of radiation, Predictions of cancers in populations | Mebis Lecture Notes |
| 11 | Radiation epidemiology, Evidence of cancers in populations | Mebis Lecture Notes |
| 12 | Concept of radiation hormesis | Mebis Lecture Notes |
| 13 | BED/EQD2 calculations, calculating the effects of treatment delays (Tpot, Tdelay) | Mebis Lecture Notes |
| 13 | BED/EQD2 calculations, calculating the effects of treatment delays (Tpot, Tdelay) | Mebis Lecture Notes |
| 14 | Tumor radiobiology, Molecular mechanisms, Drug/radiation interactions | Mebis Lecture Notes |
| Resources |
| Basic Radiotherapy Physics and Biology David S. Chang • Foster D. Lasley Indra J. Das • Marc S. Mendonca Joseph R. Dynlacht |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Has the essential knowledge about the structure and functioning of the radiation emitting machines used in radiation oncology, nuclear medicine and radiology. | X | |||||
| 2 | Able to follow and implement daily, weekly and monthly quality control programs of radiation emitting machines. | X | |||||
| 3 | Able to do the acceptance and commissioning of new machines. | X | |||||
| 4 | Able to the treatment planning of patients. | X | |||||
| 5 | Able to be a radiation safety officer of the institute. | X | |||||
| 6 | Able to participate fields research teams; individually undertake the responsibility of the work assigned and perform it independently. | X | |||||
| 7 | Able to evaluate all new information regarding the field and associate them based on available knowledge. | X | |||||
| 8 | Uses the communication and computer technology effectively in theoretical and practical studies. | X | |||||
| 9 | Able to present theoretical or research data orally or written. | X | |||||
| 10 | Adheres to ethical values and behaves according to dynamics of social responsibility. | X | |||||
| 11 | Able to do the planning of clinical implementation without giving harm to staff and patient. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |