Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| LIVER BIOCHEMISTRY I | - | Fall Semester | 2+2 | 3 | 6 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | Assist.Prof. Çağrı ÇAKICI |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assist.Prof. Derya CANSIZ, Assist.Prof. Çağrı ÇAKICI |
| Assistant(s) | Prof.Dr.Nesrin Emekli, Assoc. Prof. Dr.Türkan Yiğitbaşı, Ass. Prof .Dr.Sibel Erdem |
| Aim | To learn the biochemistry of the liver and to gain knowledge on liver tests . |
| Course Content | This course contains; Biochemical functions of the liver,Altering diseases liver function tests,Bilirubin metabolism,Bile acid structure and function,Synthesized proteins in the liver and functions,Affected enzymes in liver diseases Synthesis of,Liver tests which measure the ability,Hepatic nitrogen metabolism,Liver cell destruction tests showing,Cholestasis of the tests,hepatic metabolism of ammonia,liver and clotting factors,Liver cancer markers,Protein synthesis in liver. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-Explains liver function tests. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Discuss the functions of the liver. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Selects tests that are sensitive to non-liver diseases. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4.Defines drugs that are broken down in the liver. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.5.Discuss ammonia and urea metabolism and encephalopathy. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Compares enzymes related to liver functions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.5'- Defines nucleotidase. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3-Can compare viral hepatitis affecting the liver. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Can compare the tests used in liver dysfunction. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1.Explains the tests that measure the conjugation capacity of the liver. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Define the tests that measure the synthesis ability of the liver. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4.Debate liver cancer marker | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Compares analgesic and anti-inflammatory drugs. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Defines lipid lowering drugs. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Defines antimicrobial drugs. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6-Can access printed and electronic information sources, read and write information at a level to follow developments in biochemistry and related fields. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7-Collects data regarding liver biochemistry, inspects it by taking into account ethical values, and teaches these values. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8- Analyzes the results obtained in the field of liver biochemistry within the framework of quality processes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2. Distinguishes tests with low sensitivity. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1. Defines aminotransferases. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2. Defines phosphatases. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4. Identifies gamma glutamyl transferase. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1. Describe Hepatitis A and related tests. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2. Describe Hepatitis B and related tests. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3. Describe Hepatitis C and related tests. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4. Identifies tests for other viral hepatitis such as Hepatitis D and E. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3. Describes the tests that determine cholestasis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3. Demonstrate cholestasis tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5 –Can compare drug-induced liver tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4. Compares anticonvulsant and anesthetic drugs. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.5. Defines industrial drugs. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Biochemical functions of the liver | 1, 2 |
| 2 | Altering diseases liver function tests | 1, 2 |
| 3 | Bilirubin metabolism | 1, 2 |
| 4 | Bile acid structure and function | 1, 2 |
| 5 | Synthesized proteins in the liver and functions | 1, 2 |
| 6 | Affected enzymes in liver diseases Synthesis of | 1, 2 |
| 7 | Liver tests which measure the ability | 1, 2 |
| 8 | Hepatic nitrogen metabolism | 1, 2 |
| 9 | Liver cell destruction tests showing | 1, 2 |
| 10 | Cholestasis of the tests | 1, 2 |
| 11 | hepatic metabolism of ammonia | 1, 2 |
| 12 | liver and clotting factors | 1, 2 |
| 13 | Liver cancer markers | 1, 2 |
| 14 | Protein synthesis in liver | 1, 2 |
| Resources |
| 1) Published books of Prof.Dr.Nesrin Emekli and Assoc.Prof.Dr.Türkan Yiğitbaşı. Biochemistry Lab Book For Students (Doç.Dr.Türkan Yiğitbaşı,Prof.Dr.Nesrin Emekli) Medipol Üniversitesi Yayınları 2) Henry's Clinical Diagnosis and Management by Laboratory Methods (Mc Pherson.Pıncus) |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Knows the biochemical macromolecular metabolism. Applies and advances the knowlegde. | X | |||||
| 2 | Knows the principles of routine and research oriented biochemical technologies. | ||||||
| 3 | Practical Laboratory Applications (Sampling conditions of various body fluids and tissue samples in health and disease states, reasons of analytical errors, storage conditions of samples,working principles of technologies used in routine and research based studies, determinig reference values.) | ||||||
| 4 | Knows basic biostatistics methods, applies to experimental study results and evaluates. | ||||||
| 5 | Knows how to use specific instruments in biochemistry | ||||||
| 6 | Can access printeed and electronic literature and able to follow the advancements in biochemistry and related field. | ||||||
| 7 | Can integrate and interpret the knowledge gained in biochemistry with knowledge obtained in other fields and can generate new information. | X | |||||
| 8 | Independantly applies his/her theoretical knowledge, critical thinking skills to the area of study, evaluates the results and writes a report. | ||||||
| 9 | Defines a technical or scientific problem either with the helpof an advisor or independently, can come up with proposals and solve when needed. | ||||||
| 10 | Take on responsibility in collborative studies, contributes and work in harmony. | ||||||
| 11 | Follows national and international literature in Biochemistry, presents the work in seminars or publishes in journals. | X | |||||
| 12 | Can evaluate and teach biochemical data collection, interpretation, application and decleration recpecting cultural, scientific, social and ethical values. | ||||||
| 13 | Take responsibility in managing, evaluate the results according to the context of quality processes. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 2 | 28 | |||
| Guided Problem Solving | 14 | 2 | 28 | |||
| Resolution of Homework Problems and Submission as a Report | 5 | 10 | 50 | |||
| Term Project | 2 | 10 | 20 | |||
| Presentation of Project / Seminar | 2 | 2 | 4 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 20 | 20 | |||
| General Exam | 1 | 30 | 30 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 180 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(180/30) | 6 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| LIVER BIOCHEMISTRY I | - | Fall Semester | 2+2 | 3 | 6 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | Assist.Prof. Çağrı ÇAKICI |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assist.Prof. Derya CANSIZ, Assist.Prof. Çağrı ÇAKICI |
| Assistant(s) | Prof.Dr.Nesrin Emekli, Assoc. Prof. Dr.Türkan Yiğitbaşı, Ass. Prof .Dr.Sibel Erdem |
| Aim | To learn the biochemistry of the liver and to gain knowledge on liver tests . |
| Course Content | This course contains; Biochemical functions of the liver,Altering diseases liver function tests,Bilirubin metabolism,Bile acid structure and function,Synthesized proteins in the liver and functions,Affected enzymes in liver diseases Synthesis of,Liver tests which measure the ability,Hepatic nitrogen metabolism,Liver cell destruction tests showing,Cholestasis of the tests,hepatic metabolism of ammonia,liver and clotting factors,Liver cancer markers,Protein synthesis in liver. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-Explains liver function tests. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Discuss the functions of the liver. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Selects tests that are sensitive to non-liver diseases. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4.Defines drugs that are broken down in the liver. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.5.Discuss ammonia and urea metabolism and encephalopathy. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Compares enzymes related to liver functions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.5'- Defines nucleotidase. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3-Can compare viral hepatitis affecting the liver. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Can compare the tests used in liver dysfunction. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1.Explains the tests that measure the conjugation capacity of the liver. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Define the tests that measure the synthesis ability of the liver. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4.Debate liver cancer marker | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Compares analgesic and anti-inflammatory drugs. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Defines lipid lowering drugs. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Defines antimicrobial drugs. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6-Can access printed and electronic information sources, read and write information at a level to follow developments in biochemistry and related fields. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7-Collects data regarding liver biochemistry, inspects it by taking into account ethical values, and teaches these values. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8- Analyzes the results obtained in the field of liver biochemistry within the framework of quality processes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2. Distinguishes tests with low sensitivity. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1. Defines aminotransferases. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2. Defines phosphatases. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4. Identifies gamma glutamyl transferase. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1. Describe Hepatitis A and related tests. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2. Describe Hepatitis B and related tests. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3. Describe Hepatitis C and related tests. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4. Identifies tests for other viral hepatitis such as Hepatitis D and E. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3. Describes the tests that determine cholestasis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3. Demonstrate cholestasis tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5 –Can compare drug-induced liver tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4. Compares anticonvulsant and anesthetic drugs. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.5. Defines industrial drugs. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Biochemical functions of the liver | 1, 2 |
| 2 | Altering diseases liver function tests | 1, 2 |
| 3 | Bilirubin metabolism | 1, 2 |
| 4 | Bile acid structure and function | 1, 2 |
| 5 | Synthesized proteins in the liver and functions | 1, 2 |
| 6 | Affected enzymes in liver diseases Synthesis of | 1, 2 |
| 7 | Liver tests which measure the ability | 1, 2 |
| 8 | Hepatic nitrogen metabolism | 1, 2 |
| 9 | Liver cell destruction tests showing | 1, 2 |
| 10 | Cholestasis of the tests | 1, 2 |
| 11 | hepatic metabolism of ammonia | 1, 2 |
| 12 | liver and clotting factors | 1, 2 |
| 13 | Liver cancer markers | 1, 2 |
| 14 | Protein synthesis in liver | 1, 2 |
| Resources |
| 1) Published books of Prof.Dr.Nesrin Emekli and Assoc.Prof.Dr.Türkan Yiğitbaşı. Biochemistry Lab Book For Students (Doç.Dr.Türkan Yiğitbaşı,Prof.Dr.Nesrin Emekli) Medipol Üniversitesi Yayınları 2) Henry's Clinical Diagnosis and Management by Laboratory Methods (Mc Pherson.Pıncus) |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Knows the biochemical macromolecular metabolism. Applies and advances the knowlegde. | X | |||||
| 2 | Knows the principles of routine and research oriented biochemical technologies. | ||||||
| 3 | Practical Laboratory Applications (Sampling conditions of various body fluids and tissue samples in health and disease states, reasons of analytical errors, storage conditions of samples,working principles of technologies used in routine and research based studies, determinig reference values.) | ||||||
| 4 | Knows basic biostatistics methods, applies to experimental study results and evaluates. | ||||||
| 5 | Knows how to use specific instruments in biochemistry | ||||||
| 6 | Can access printeed and electronic literature and able to follow the advancements in biochemistry and related field. | ||||||
| 7 | Can integrate and interpret the knowledge gained in biochemistry with knowledge obtained in other fields and can generate new information. | X | |||||
| 8 | Independantly applies his/her theoretical knowledge, critical thinking skills to the area of study, evaluates the results and writes a report. | ||||||
| 9 | Defines a technical or scientific problem either with the helpof an advisor or independently, can come up with proposals and solve when needed. | ||||||
| 10 | Take on responsibility in collborative studies, contributes and work in harmony. | ||||||
| 11 | Follows national and international literature in Biochemistry, presents the work in seminars or publishes in journals. | X | |||||
| 12 | Can evaluate and teach biochemical data collection, interpretation, application and decleration recpecting cultural, scientific, social and ethical values. | ||||||
| 13 | Take responsibility in managing, evaluate the results according to the context of quality processes. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |