Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| MEDICAL BIOCHEMISTY | - | Yearly | 4+0 | - | 1 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | First Cycle (Bachelor's Degree) |
| Course Type | Committee Course |
| Course Coordinator | Prof.Dr. Neslin EMEKLİ |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assist.Prof. Gözde ÜLFER |
| Assistant(s) | |
| Aim | To teach the importance of proteins, enzymes, lipoproteins in clinical biochemistry and their role in monitoring the diagnosis and treatment of diseases. The role of lipoproteins in the diagnosis and treatment of atherosclerosis, other factors in atherosclerosis, blood glucose elevation, regulation, liver function tests, oral glucose tolerance test, bilirubin measurement, and the importance and importance of blood gases in clinical biochemistry. |
| Course Content | This course contains; Plasma proteins and immunoglobulins,Clinical enzymology,Tumor biochemistry,Clinical Biochemistry,Determination of bilirubin (Lab),Taking laboratory samples under suitable conditions and transporting them to the laboratory,Lipoprotein metabolism and atherosclerosis,Blood gases and respiratory biochemistry,Diabetes biochemistry and OGTT,Oral glucose tolerance test (LAB),Blood glucose regulation ,Liver function tests. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1.The functions of transport, storage, adjustment of osmotic and oncotic pressure, regulation of blood pH, formation and prevention of clot in hemostatic system, properties and functions of immune globulins are explained. Examples of the functions of proteins as enzymes are given. Students are informed about protein measurement methods. Students are informed about the evaluation of chemical and electrophoretic measurement methods in terms of plasma proteins. | 16, 17, 19, 9 | A, D, E, G |
| 2.What is used at the cellular level of the enzymes used in the clinic is explained. The importance of damage enzymes used in various diseases and their evaluations are explained. Enzymes used as cardiac markers, enzymes used as kidney function tests, what enzymes used as liver function tests mean, how measurement methods are performed, what errors are caused by our students are informed. | 16, 17, 19, 9 | A, D, E, G |
| 3.After informing about the mechanisms of growth and proliferation in cancer cells which can occur due to various unknown causes and DNA damage, the meaning of the laboratory tests used to determine these changes is explained. Information is given about the importance of these markers in monitoring the treatment. Regimens in multidisciplinary treatment methods, laboratory samples are given to prognostic results. | 16, 17, 19, 9 | A, D, E, G |
| 4.In clinical biochemistry laboratories, the importance of clinical biochemistry laboratory results is explained in terms of approval or rejection of diagnosis, determining prognosis, detection of disease and monitoring of treatment. Information about human resources and devices, communication skills, medical, education and administrative responsibilities are discussed. | 16, 17, 19, 9 | A, D, E, G |
| 6.Laboratory conditions are discussed in order to get healthy results. What is the safety of the laboratory, how to work in biological materials, the safety rules of chemical studies, how to create the necessary conditions for the safety of carcinogens, how the wastes are classified and which methods are used, the rules of transport of blood, urine and tissue samples are taught. | 16, 17, 19, 9 | A, D, E, G |
| 7.What is lipopoteins, how dietary lipids are transformed into lipoproteins, ways of transporting from the lymph system to the large circulation, informations about the fate of the liver and extra-liver tissues, the measurements that will be useful in the clinic, the meaning of lipoprotein and apoprotein measurements, the efficacy of lipoproteins and hemostatic system in atherosclerosis formation . Information is given about how the tests are interpreted. | 16, 17, 19, 9 | A, D, E, G |
| 5.It is explained how the bilirub, which is among the tests of liver dysfunction, passes from the hemoglobin into the blood. Biluribunun blood in the form of, pre-liver, liver and post-liver jaundice in how the biliribın is known and how to use it to monitor the diagnosis and treatment is given. Serum anconjugate and conjugate bilirubin, neonatal jaundice, interaction with glucuronic acid are discussed. | 16, 17, 19, 9 | A, D, E, G |
| 8.After giving information about the importance of acid base balance and blood gas laboratory data, the importance of buffer solutions and pK values are explained. Hydrogen ion concentration in extracellular fluid, arterial blood pH values, how to regulate the hydrogen ion in the buffer systems are explained. After summarizing the functions of the kidneys and lungs and various hormones and enzymes in the acid base balance, how these values are reflected in the laboratory are used for diagnosis and monitoring of the treatment. | 16, 17, 19, 9 | A, D, E, G |
| 9.After a brief information about the most common disease in the community, diabetes mellitus, laboratory diagnosis of diabetes, WHO diagnostic criteria, the importance of hemoglobin AC values are explained. It is explained why HbAic is important in complications seen in diabetic patients. In latent diabetes, fasting blood glucose and oral glucose loading test are given. The meaning of insulin dependent and independent types of diabetes is explained. | 16, 17, 19, 9 | A, D, E, G |
| 10.When glucose tolerance is impaired, insulin resistance information is given and the points that should be considered in oral glucose tolerance test are explained. What is the content of the protocol of the test, how much glucose should be given, pre-test, post-test and issues to be considered during testing are explained. | 16, 17, 19, 9 | A, D, E, G |
| 11.Metabolic and hormonal arrangements in the organism are described in order to keep blood sugar between the reference values. The relationship between the amount of glucose taken after entering the cell and the amount of glucose taken with the diet, the importance of fatty acids in metabolic control, the mechanism of action of all hormones that are effective against insulin and insulin, and how they are reflected in the clinic are explained. | 16, 17, 19, 9 | A, D, E, G |
| 12.Liver function tests, liver failure, liver dysfunction and liver disease, diagnosis, prognosis and prognosis are used for the purpose of diagnosis. The importance of liver parenchymal cells and the ability to regenerate are given. Tests and examples of liver function tests are explained. The meaning of liver damage, liver dysfunction and cholestasis tests are shown with examples. | 16, 17, 19, 9 | A, D, E, G |
| Teaching Methods: | 16: Question - Answer Technique, 17: Experimental Technique, 19: Brainstorming Technique, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework, G: Quiz |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Plasma proteins and immunoglobulins | In MEBIS, the student was informed about the subject. |
| 2 | Clinical enzymology | In MEBIS, the student was informed about the subject. |
| 3 | Tumor biochemistry | In MEBIS, the student was informed about the subject. |
| 4 | Clinical Biochemistry | In MEBIS, the student was informed about the subject. |
| 5 | Determination of bilirubin (Lab) | In MEBIS, the student was informed about the subject. |
| 6 | Taking laboratory samples under suitable conditions and transporting them to the laboratory | In MEBIS, the student was informed about the subject. |
| 7 | Lipoprotein metabolism and atherosclerosis | In MEBIS, the student was informed about the subject. |
| 8 | Blood gases and respiratory biochemistry | In MEBIS, the student was informed about the subject. |
| 9 | Diabetes biochemistry and OGTT | In MEBIS, the student was informed about the subject. |
| 9 | Oral glucose tolerance test (LAB) | In MEBIS, the student was informed about the subject. |
| 10 | Blood glucose regulation | In MEBIS, the student was informed about the subject. |
| 11 | Liver function tests | In MEBIS, the student was informed about the subject. |
| Resources |
| 1.Basic and Applied Biochemistry (Nesrin Emekli ), 2.Biochemistry (Fügen Gürdöl ve Evin Ademoğlu), 3.Biochemistry Laboratory(Türkan Yiğitbaşı,Nesrin Emekli). |
| 4.Harper's Biochemistry, 5.Lehninger Principles of Biochemistry, 6.Henry's Clinical Diagnosis and Management by Laboratory Methods. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Knows structural (morphological) and operational (functional) properties of the normal human (medical) and disorder (disease) states | X | |||||
| 2 | Knows diagnostic methods and treatment modalities of disorders (diseases). | X | |||||
| 3 | Knows the causes of disease conditions, ways of protection and methods of promoting and improving community health. | X | |||||
| 4 | Knows the methods of developing and applying health related knowledge at advanced level. | X | |||||
| 5 | Able to reach multidisciplinary advanced knowledge regarding health-related disciplines, interpret and apply the knowledge. | X | |||||
| 6 | Performs a complete clinical examination of human body structurally and functionally and identifies problems. | ||||||
| 7 | Interprets laboratory results for diagnosis, compares with clinical data and develop solution proposals. | X | |||||
| 8 | Selects and implements appropriate tools for the promotion and development of individual and community health. | X | |||||
| 9 | Plans and conducts an advanced study on health independently. | X | |||||
| 10 | Develops new strategic approaches to solve the problems encountered in the promotion and development of individual and community health. | X | |||||
| 11 | Takes the responsibility of any type of practice when diagnosing and treating human body | ||||||
| 12 | Takes the role as a leader or a team worker when solving health related problems. | X | |||||
| 13 | Evaluates knowledge and skills regarding health with a critical approach and develops a positive attitude towards lifelong learning. | X | |||||
| 14 | Informs the patient, related people, institutions and the society about the health problems and transfers solution proposals in writing, verbally and visually using effective communication means. | X | |||||
| 15 | Critically reviews, develops and acts on changes in social relations and norms that guide such relationships. | X | |||||
| 16 | Uses English at least at the European Language Portfolio B2 Level, monitors knowledge and communicates in his field. | X | |||||
| 17 | Able to use advanced computer skills and informatics and communication technologies at a level required by the field. | ||||||
| 18 | Acquires, interprets, implements and announces data related to the health and acts in accordance with social, scientific, cultural and ethical values and teaches these values. | X | |||||
| 19 | Develops strategies, policy and implementation plans in the field of health and evaluates the results obtained within the framework of quality processes. | X | |||||
| 20 | Shares studies on the promotion and development of health with interdisciplinary specialists systematically, supporting with quantitative and qualitative data. | X | |||||
| 21 | Has adequate awareness on occupational health and safety issues. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 40 | |
| Rate of Final Exam to Success | 60 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 0 | 0 | 0 | |||
| Guided Problem Solving | 0 | 0 | 0 | |||
| Resolution of Homework Problems and Submission as a Report | 0 | 0 | 0 | |||
| Term Project | 0 | 0 | 0 | |||
| Presentation of Project / Seminar | 0 | 0 | 0 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 0 | 0 | 0 | |||
| General Exam | 0 | 0 | 0 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 0 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(0/30) | 0 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| MEDICAL BIOCHEMISTY | - | Yearly | 4+0 | - | 1 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | First Cycle (Bachelor's Degree) |
| Course Type | Committee Course |
| Course Coordinator | Prof.Dr. Neslin EMEKLİ |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assist.Prof. Gözde ÜLFER |
| Assistant(s) | |
| Aim | To teach the importance of proteins, enzymes, lipoproteins in clinical biochemistry and their role in monitoring the diagnosis and treatment of diseases. The role of lipoproteins in the diagnosis and treatment of atherosclerosis, other factors in atherosclerosis, blood glucose elevation, regulation, liver function tests, oral glucose tolerance test, bilirubin measurement, and the importance and importance of blood gases in clinical biochemistry. |
| Course Content | This course contains; Plasma proteins and immunoglobulins,Clinical enzymology,Tumor biochemistry,Clinical Biochemistry,Determination of bilirubin (Lab),Taking laboratory samples under suitable conditions and transporting them to the laboratory,Lipoprotein metabolism and atherosclerosis,Blood gases and respiratory biochemistry,Diabetes biochemistry and OGTT,Oral glucose tolerance test (LAB),Blood glucose regulation ,Liver function tests. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1.The functions of transport, storage, adjustment of osmotic and oncotic pressure, regulation of blood pH, formation and prevention of clot in hemostatic system, properties and functions of immune globulins are explained. Examples of the functions of proteins as enzymes are given. Students are informed about protein measurement methods. Students are informed about the evaluation of chemical and electrophoretic measurement methods in terms of plasma proteins. | 16, 17, 19, 9 | A, D, E, G |
| 2.What is used at the cellular level of the enzymes used in the clinic is explained. The importance of damage enzymes used in various diseases and their evaluations are explained. Enzymes used as cardiac markers, enzymes used as kidney function tests, what enzymes used as liver function tests mean, how measurement methods are performed, what errors are caused by our students are informed. | 16, 17, 19, 9 | A, D, E, G |
| 3.After informing about the mechanisms of growth and proliferation in cancer cells which can occur due to various unknown causes and DNA damage, the meaning of the laboratory tests used to determine these changes is explained. Information is given about the importance of these markers in monitoring the treatment. Regimens in multidisciplinary treatment methods, laboratory samples are given to prognostic results. | 16, 17, 19, 9 | A, D, E, G |
| 4.In clinical biochemistry laboratories, the importance of clinical biochemistry laboratory results is explained in terms of approval or rejection of diagnosis, determining prognosis, detection of disease and monitoring of treatment. Information about human resources and devices, communication skills, medical, education and administrative responsibilities are discussed. | 16, 17, 19, 9 | A, D, E, G |
| 6.Laboratory conditions are discussed in order to get healthy results. What is the safety of the laboratory, how to work in biological materials, the safety rules of chemical studies, how to create the necessary conditions for the safety of carcinogens, how the wastes are classified and which methods are used, the rules of transport of blood, urine and tissue samples are taught. | 16, 17, 19, 9 | A, D, E, G |
| 7.What is lipopoteins, how dietary lipids are transformed into lipoproteins, ways of transporting from the lymph system to the large circulation, informations about the fate of the liver and extra-liver tissues, the measurements that will be useful in the clinic, the meaning of lipoprotein and apoprotein measurements, the efficacy of lipoproteins and hemostatic system in atherosclerosis formation . Information is given about how the tests are interpreted. | 16, 17, 19, 9 | A, D, E, G |
| 5.It is explained how the bilirub, which is among the tests of liver dysfunction, passes from the hemoglobin into the blood. Biluribunun blood in the form of, pre-liver, liver and post-liver jaundice in how the biliribın is known and how to use it to monitor the diagnosis and treatment is given. Serum anconjugate and conjugate bilirubin, neonatal jaundice, interaction with glucuronic acid are discussed. | 16, 17, 19, 9 | A, D, E, G |
| 8.After giving information about the importance of acid base balance and blood gas laboratory data, the importance of buffer solutions and pK values are explained. Hydrogen ion concentration in extracellular fluid, arterial blood pH values, how to regulate the hydrogen ion in the buffer systems are explained. After summarizing the functions of the kidneys and lungs and various hormones and enzymes in the acid base balance, how these values are reflected in the laboratory are used for diagnosis and monitoring of the treatment. | 16, 17, 19, 9 | A, D, E, G |
| 9.After a brief information about the most common disease in the community, diabetes mellitus, laboratory diagnosis of diabetes, WHO diagnostic criteria, the importance of hemoglobin AC values are explained. It is explained why HbAic is important in complications seen in diabetic patients. In latent diabetes, fasting blood glucose and oral glucose loading test are given. The meaning of insulin dependent and independent types of diabetes is explained. | 16, 17, 19, 9 | A, D, E, G |
| 10.When glucose tolerance is impaired, insulin resistance information is given and the points that should be considered in oral glucose tolerance test are explained. What is the content of the protocol of the test, how much glucose should be given, pre-test, post-test and issues to be considered during testing are explained. | 16, 17, 19, 9 | A, D, E, G |
| 11.Metabolic and hormonal arrangements in the organism are described in order to keep blood sugar between the reference values. The relationship between the amount of glucose taken after entering the cell and the amount of glucose taken with the diet, the importance of fatty acids in metabolic control, the mechanism of action of all hormones that are effective against insulin and insulin, and how they are reflected in the clinic are explained. | 16, 17, 19, 9 | A, D, E, G |
| 12.Liver function tests, liver failure, liver dysfunction and liver disease, diagnosis, prognosis and prognosis are used for the purpose of diagnosis. The importance of liver parenchymal cells and the ability to regenerate are given. Tests and examples of liver function tests are explained. The meaning of liver damage, liver dysfunction and cholestasis tests are shown with examples. | 16, 17, 19, 9 | A, D, E, G |
| Teaching Methods: | 16: Question - Answer Technique, 17: Experimental Technique, 19: Brainstorming Technique, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework, G: Quiz |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Plasma proteins and immunoglobulins | In MEBIS, the student was informed about the subject. |
| 2 | Clinical enzymology | In MEBIS, the student was informed about the subject. |
| 3 | Tumor biochemistry | In MEBIS, the student was informed about the subject. |
| 4 | Clinical Biochemistry | In MEBIS, the student was informed about the subject. |
| 5 | Determination of bilirubin (Lab) | In MEBIS, the student was informed about the subject. |
| 6 | Taking laboratory samples under suitable conditions and transporting them to the laboratory | In MEBIS, the student was informed about the subject. |
| 7 | Lipoprotein metabolism and atherosclerosis | In MEBIS, the student was informed about the subject. |
| 8 | Blood gases and respiratory biochemistry | In MEBIS, the student was informed about the subject. |
| 9 | Diabetes biochemistry and OGTT | In MEBIS, the student was informed about the subject. |
| 9 | Oral glucose tolerance test (LAB) | In MEBIS, the student was informed about the subject. |
| 10 | Blood glucose regulation | In MEBIS, the student was informed about the subject. |
| 11 | Liver function tests | In MEBIS, the student was informed about the subject. |
| Resources |
| 1.Basic and Applied Biochemistry (Nesrin Emekli ), 2.Biochemistry (Fügen Gürdöl ve Evin Ademoğlu), 3.Biochemistry Laboratory(Türkan Yiğitbaşı,Nesrin Emekli). |
| 4.Harper's Biochemistry, 5.Lehninger Principles of Biochemistry, 6.Henry's Clinical Diagnosis and Management by Laboratory Methods. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Knows structural (morphological) and operational (functional) properties of the normal human (medical) and disorder (disease) states | X | |||||
| 2 | Knows diagnostic methods and treatment modalities of disorders (diseases). | X | |||||
| 3 | Knows the causes of disease conditions, ways of protection and methods of promoting and improving community health. | X | |||||
| 4 | Knows the methods of developing and applying health related knowledge at advanced level. | X | |||||
| 5 | Able to reach multidisciplinary advanced knowledge regarding health-related disciplines, interpret and apply the knowledge. | X | |||||
| 6 | Performs a complete clinical examination of human body structurally and functionally and identifies problems. | ||||||
| 7 | Interprets laboratory results for diagnosis, compares with clinical data and develop solution proposals. | X | |||||
| 8 | Selects and implements appropriate tools for the promotion and development of individual and community health. | X | |||||
| 9 | Plans and conducts an advanced study on health independently. | X | |||||
| 10 | Develops new strategic approaches to solve the problems encountered in the promotion and development of individual and community health. | X | |||||
| 11 | Takes the responsibility of any type of practice when diagnosing and treating human body | ||||||
| 12 | Takes the role as a leader or a team worker when solving health related problems. | X | |||||
| 13 | Evaluates knowledge and skills regarding health with a critical approach and develops a positive attitude towards lifelong learning. | X | |||||
| 14 | Informs the patient, related people, institutions and the society about the health problems and transfers solution proposals in writing, verbally and visually using effective communication means. | X | |||||
| 15 | Critically reviews, develops and acts on changes in social relations and norms that guide such relationships. | X | |||||
| 16 | Uses English at least at the European Language Portfolio B2 Level, monitors knowledge and communicates in his field. | X | |||||
| 17 | Able to use advanced computer skills and informatics and communication technologies at a level required by the field. | ||||||
| 18 | Acquires, interprets, implements and announces data related to the health and acts in accordance with social, scientific, cultural and ethical values and teaches these values. | X | |||||
| 19 | Develops strategies, policy and implementation plans in the field of health and evaluates the results obtained within the framework of quality processes. | X | |||||
| 20 | Shares studies on the promotion and development of health with interdisciplinary specialists systematically, supporting with quantitative and qualitative data. | X | |||||
| 21 | Has adequate awareness on occupational health and safety issues. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 40 | |
| Rate of Final Exam to Success | 60 | |
| Total | 100 | |