Course Description

Course Description Course Outline Course Contribution to Program Qualifications Assessment Methods ECTS-Workload Detail Informations of the Course Numerical Data

Course Description

Course	Code	Semester	T+P (Hour)	Credit	ECTS
MEDICAL BIOLOGY & GENETICS	-	Yearly	44+10	-	4

Course Program

Pazartesi 09:00-09:45

Pazartesi 10:00-10:45

Salı 13:30-14:15

Salı 14:30-15:15

Salı 15:30-16:15

Salı 16:30-17:15

Çarşamba 11:00-11:45

Çarşamba 12:00-12:45

Perşembe 11:00-11:45

Perşembe 12:00-12:45

Perşembe 13:30-14:15

Perşembe 14:30-15:15

Perşembe 15:30-16:15

Perşembe 16:30-17:15

Cuma 09:00-09:45

Cuma 10:00-10:45

Cuma 11:00-11:45

Cuma 12:00-12:45

Cuma 13:30-14:15

Cuma 14:30-15:15

Prerequisites Courses
Recommended Elective Courses

Language of Course	English
Course Level	First Cycle (Bachelor's Degree)
Course Type	Committee Course
Course Coordinator	Assoc.Prof. Nihal KARAKAŞ
Name of Lecturer(s)	Assist.Prof. Sven Pierre L. VILAIN, Assist.Prof. Berrak ÇAĞLAYAN, Prof.Dr. Esra ÇAĞAVİ, Assist.Prof. Salih GENCER, Assoc.Prof. Nihal KARAKAŞ, Assist.Prof. Yasemin YOZGAT BYRNE
Assistant(s)	None
Aim	The aim of this course is to define and evaluate the fundamental concepts in medical biology and medical genetics, that will lay the foundation for first year medical students for understanding of basic cellular mechanisms as well as associating the dysfunctional molecular mechanisms with human diseases.
Course Content	This course contains; Fundamentals of life - the cell,Chemical principles of the cell biology and biosynthesis,Protein structure and function,Genetic material of the cell - DNA, chromosomes and the genome,DNA replication and repair,RNA structure and transcription,Genetic code and tranlation,Control of gene expression and genetic switches-I,Control of gene expression and genetic switches-II,Epigenetics and epigenome,Molecular techniques and clinical applications,The structure and function of cellular membranes and transport across the membrane,Cellular compartments: Organelles-I,Cellular compartments: Organelles-II,Cellular compartments: Organelles-III,Vesicular transport within the cell,Endocytosis, exocytosis and membrane transport,Cell Signaling -I,Cell Signaling -II,Cytoskeleton and motor proteins,Cell adhesion, junctions and extracellular matrix,Cell cycle,Cell senescence and cell death,Developmental biology and organ regeneration,Stem cells and regenerative medicine,Cancer biology and molecular basis of cancer,Current therapeutic approaches and cancer therapy,Fundamentals of medical genetics,Mendelian/non-mendelian/population genetics,Principles of autosomal genetic inheritance,Principles of genetic inheritance sex chromosomes,Gonosomal and autosomal chromosomal abnormalities,Prenatal testing and genetic counseling.

Dersin Öğrenme Kazanımları	Teaching Methods	Assessment Methods
This course is to define and evaluate the fundamental concepts in medical biology and medical genetics, that will lay the foundation for first year medical students for understanding of basic cellular mechanisms as well as associating the dysfunctional molecular mechanisms with human diseases.	10, 12, 14, 16, 17, 19, 3, 37, 4, 9	A, E, G

Teaching Methods:	10: Discussion Method, 12: Problem Solving Method, 14: Self Study Method, 16: Question - Answer Technique, 17: Experimental Technique, 19: Brainstorming Technique, 3: Problem Baded Learning Model, 37: Computer-Internet Supported Instruction, 4: Inquiry-Based Learning, 9: Lecture Method
Assessment Methods:	A: Traditional Written Exam, E: Homework, G: Quiz

Course Outline

Order	Subjects	Preliminary Work
1	Fundamentals of life - the cell
2	Chemical principles of the cell biology and biosynthesis
3	Protein structure and function
4	Genetic material of the cell - DNA, chromosomes and the genome
5	DNA replication and repair
6	RNA structure and transcription
7	Genetic code and tranlation
8	Control of gene expression and genetic switches-I
9	Control of gene expression and genetic switches-II
10	Epigenetics and epigenome
11	Molecular techniques and clinical applications
12	The structure and function of cellular membranes and transport across the membrane
13	Cellular compartments: Organelles-I
14	Cellular compartments: Organelles-II
15	Cellular compartments: Organelles-III
16	Vesicular transport within the cell
17	Endocytosis, exocytosis and membrane transport
18	Cell Signaling -I
19	Cell Signaling -II
20	Cytoskeleton and motor proteins
21	Cell adhesion, junctions and extracellular matrix
22	Cell cycle
23	Cell senescence and cell death
24	Developmental biology and organ regeneration
25	Stem cells and regenerative medicine
26	Cancer biology and molecular basis of cancer
27	Current therapeutic approaches and cancer therapy
28	Fundamentals of medical genetics
29	Mendelian/non-mendelian/population genetics
30	Principles of autosomal genetic inheritance
31	Principles of genetic inheritance sex chromosomes
32	Gonosomal and autosomal chromosomal abnormalities
33	Prenatal testing and genetic counseling

Resources

Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter “Essential Cell Biology” Fifth Edition, Garland Science Publishers, USA, 2019.

1. Presentations of lecture notes 2. Alberts, Bray, Hopkin, Johnson, Lewis, Raff, Roberts, Walter "Essential Cell Biology" Fifth Edition, Garland-Norton Publishers, USA, 2019. 3. Alberts, Johnson, Lewis, Raff, Roberts, Walter “Molecular Biology of the Cell” Seventh Edition, Garland Science Publishers, USA, 2015. 4. Stephen R Goodman “Medical Cell Biology”, Third Edition, Elsevier, USA, 2007.

Course Contribution to Program Qualifications

Course Contribution to Program Qualifications
No	Program Qualification	Contribution Level
No	Program Qualification	1	2	3	4	5
1	PQ1: Knows the morphological and functional normal and abnormal structure of human body.
2	PQ2: Knows the essential ways of determining the underlying causes of the pathologies with basic scientific approaches and the diagnoses of illnesses and disorders.
3	PQ3: Knows the reasons for illnesses, the ways of protection, and the methods of promotion and improvement of public health.
4	PQ4: Knows the methods of advancing his/her knowledge about health and its practice.
5	PQ5: Accesses, interprets and applies the advanced interdisciplinary information related to health.
6	PQ6: Performs a complete clinical examination of the human body, both morphologically and functionally and defines the problems.
7	PQ7: Interprets examination data for diagnoses, compares with clinical data, and provides solutions.
8	PQ8: Selects and applies appropriate tools for promotion and improvement of individual and public health.
9	PQ9: Plans and conducts an advanced study of health independently.
10	PQ10: Takes responsibility individually and as a team member to solve the problems encountered in the promotion and improvement of individual and public health.
11	PQ11: Takes responsibility for any intervention on the human body for the diagnosis and treatment.
12	PQ12: Determines personal learning requirements and decides and develops a positive lifelong learning attitude.
13	PQ13: Evaluates the information gained in the field of health with a critical approach.
14	PQ14: Informs the patient, the relevant people and institutions, and the public about the health problem and conveys recommendations of solutions in writing and/or verbally.
15	PQ15: Shares their recommendations on promotion and improvement of health with interdisciplinary experts by supporting with data.
16	PQ16: Uses English at least at the General Level of European Language Portfolio B1, follows resources in his/her field and communicates.
17	PQ17: Uses computer software, information, and communication technologies at least at the Advanced Level of European Computer Operating License.
18	PQ18: Acts in accordance with social, scientific, cultural and ethical values in the stages of obtaining, interpreting, applying and announcing the data related to the field of health.
19	PQ19: Develops strategy, policy and implementation plans on health issues and evaluate the results obtained the framework of quality processes.
20	PQ20: Systematically shares his/her works on promoting and improving health with quantitative and qualitative data and interdisciplinary experts.
21	PQ21: Has sufficient awareness on occupational health and safety issues.

Assessment Methods

Contribution Level	Absolute Evaluation
Rate of Midterm Exam to Success		40
Rate of Final Exam to Success		60
Total		100

ECTS / Workload Table
Activities	Number of	Duration(Hour)	Total Workload(Hour)
Course Hours	0	0	0
Course Hours	54	1	54
Guided Problem Solving	0	0	0
Guided Problem Solving	0	0	0
Resolution of Homework Problems and Submission as a Report	0	0	0
Resolution of Homework Problems and Submission as a Report	0	0	0
Term Project	0	0	0
Term Project	24	1	24
Presentation of Project / Seminar	0	0	0
Presentation of Project / Seminar	0	0	0
Quiz	0	0	0
Quiz	0	0	0
Midterm Exam	4	5	20
Midterm Exam	0	0	0
General Exam	0	0	0
General Exam	1	20	20
Performance Task, Maintenance Plan	0	0	0
Performance Task, Maintenance Plan	0	0	0
Total Workload(Hour)			118
*Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30=(118/30)**			4
ECTS of the course: 30 hours of work is counted as 1 ECTS credit.

Detail Informations of the Course