Course Description

Course Description Course Outline Course Contribution to Program Qualifications Assessment Methods ECTS-Workload Detail Informations of the Course Numerical Data

Course Description

Course	Code	Semester	T+P (Hour)	Credit	ECTS
Endocrine & Nutrition	-	Fall Semester	72+14	-	7

Course Program

Prerequisites Courses
Recommended Elective Courses

Language of Course	English
Course Level	First Cycle (Bachelor's Degree)
Course Type	Committee
Course Coordinator	Prof.Dr. Abdulkadir ÖMER
Name of Lecturer(s)	Prof.Dr. Abdulkadir ÖMER
Assistant(s)	Prof.Dr. Bahar MÜEZZİNOĞLU, Prof.Dr. Sergülen DERVİŞOĞLU, Öğr.Gör. Rukiye Nilgün ERDOĞAN Dr.Öğr.Üye. Çağlar MACİT, Prof.Dr. Recep Serdar ALPAN, Öğr.Gör.Dr. Burçak Deniz DEDEOĞLU, Doç.Dr. Mustafa GÜZEL Prof.Dr. Ayhan TAŞTEKİN, Prof.Dr. Seniye Sema ANAK, Prof.Dr. Sedat OKTEM, Prof.Dr. Abdullah ERDEM, Prof.Dr. Celal AKDENİZ, Prof.Dr. Cihangir AKGÜN, Prof.Dr. Gökhan BAYSOY, Doç.Dr. Öznur KÜÇÜK, Prof.Dr. İlke ÖZAHİ İPEK, Doç.Dr. Yasemin TOPÇU, Doç.Dr. Nalan KARABAYIR, Dr.Öğr.Üye. Remzi ERKESİM, Dr.Öğr.Üye. Yöntem YAMAN, Dr.Öğr.Üye. Hülya BİLGEN, Dr.Öğr.Üye. Sevgki CHODZA OGLOU, Prof.Dr. Zeynep ATA Doç.Dr. Mesut YILMAZ, Dr.Öğr.Üye. Özlem GÜVEN, Dr.Öğr.Üye. Canan SEVER, Dr.Öğr.Üye. Betül GİRAY, Dr.Öğr.Üye. Selda AYDIN, Dr.Öğr.Üye. Okan DERİN Prof.Dr. Abdulkadir ÖMER, Prof.Dr. Mustafa ÖZTÜRK, Prof.Dr. Özcan YILDIZ, Doç.Dr. Ömür Gökmen SEVİNDİK, Dr.Öğr.Üye. Hüseyin Saffet BEKÖZ, Dr.Öğr.Üye. Canan SEVER, Dr.Öğr.Üye. Ali Timuçin ATAYOĞLU, Prof.Dr. Vedat GÖRAL, Doç.Dr. Meryem CAN Prof.Dr. Tamer ATASEVER, Prof.Dr. Ayşenur CİLA, Prof.Dr. Erol AKGÜL, Prof.Dr. Cengiz EROL, Dr.Öğr.Üye. Tansel ÇAKIR Prof.Dr. Müjgan ÇALIŞKAN EVREN, Prof.Dr. Mustafa ÖNCEL, Prof.Dr. Fazlı Cem GEZEN, Dr.Öğr.Üye. Pelin BASIM, HAMDİ KARAKAYALI
Aim	The purpose of this committee is to acquire knowledge about the normal structure of the endocrine system, its functions, the etiopathogenesis of diseases related to this system, the basic clinical and laboratory findings, the diagnostic methods and the drugs used for the treatment of the diseases of the endocrine system.
Course Content	This course contains; Pathology of Thyroid disease, Basics of thyroid function testsclinical features and treatment of hypothyroidism, thyroiditis, iodine deficiency, hyperthyroidism, thyroid cancer. Radiological (Ultrasound and scan) features of thyroiditis, thyroid nodules, Graves disease, toxic and non-toxic nodular disease. ,Macroscopic and microscopic features of pituitary disease, interpretation of anterior and posterior pituitary functions, review of pitruitary hormone changes and correlation with hypothalamic hormones and end hormones, concept of macroprolactinemia, Stalk effect and hook effects for interpretation of prolactin elevation, clinicali lab and MR features of acromegaly, Cushing disease, TSH secreting tumors and prolactinoma. Diagnosis , differential diagnosis of pituitary tumors. Radiological features of Pituitary tumors, empty sella, hypophysitis,Hypopituitarism, diabetes incipitus, clinical features, treatment,Macroscopic and microscopic anatomic changes in various parathyroid disease, Approach to hypercalcemia and hypocalcemia. Clinical, lab and radiological features of primary hyperparathyroidism, osteoporosis, hypoparathyroidism, end stage renal disease. Clinical and lab features of MEN syndromes. Interpretation of bone mineral density, Management of vitamin D deficincy,Clinical features of type 1 and type 2 diabetes, the importance of diabetes... diagnosİs of diabetes mellitus type 1, type 2 gestational diabetes, the importance of glycosylated hemoglobin and oral glucose tolerance test. The macroscopic and microscopic anatomic features of diabetes, autoimmune development, resistance to insulin, polycystic ovary syndrome, metabolic syndrome. Acute and chronic complications of type diabetes- prevention and treatment. Prevention or Cardiovascular complications in type 2 diabetes. The pharmacokinetic features of insulins, how to establish an insulin treatment. The medications used for type 2 diabetes: treatment effects and adverse effects. The treatment algorithm in type 2 diabetes. Hypoglycemia, prevention and treatment. Non-diabetic hypoglycemia,Macroscopic and microscopic anatomic changes in adrenal disease. Review of hypothalamus, pituitary and adrenal gland axis. Symptoms of adrenal insufficiency, clinical features, laboratory findings, diagnosis and treatment. Review of mineralocorticoid and glucocorticoid actions of steroids. Cushing’s syndrome: screening, diagnosis, identification of the hypersecretion site. Secondary hypertension: primary hyperaldosteronism, pheochromocytoma.

Dersin Öğrenme Kazanımları	Teaching Methods	Assessment Methods
Microbiological features of endocrine system disease
1. Defines the anatomical structures of the endocrine system. particularly the relation of hypothalamus, pituitary and Target and organs as well as hormonal secretion patterns including positive and negative feedback, stalk and hook effects to explain prolactin elevations	37, 9	A
2. At the end of this committee, students list the etiopathogenesis, clinic, laboratory signs and histopathological findings of endocrine system diseases.Specifically includes Hypothyroidism, hyperhyroidism, thyroid nodules and thyroid cancers, thyroiditis, iodine deficiency, pituitary insufficiency, Cushing disease, prolactinoma, acromegaly, approach to pituitary tumors, İmaging modalities to diagnose pityitary disease, diabetes insipidus, hypercalcemia and hypocalcemia, osteoporosis, adrenal insufficiency, differentiation of primary versus secondary adrenal insufficiency, Cushing syndrome differential diagnosis of primary versus secondary or tertiary. Adrenal incidentaloma, hypoglycemia, basics of nutrition and heatly eating, obesity, endocrine hypertension. Endocrine basics of development from childhood to puberty, puberty precox, delayed puberty, endocrine hypertension, pheochromocytoma, Primary hyperaldosteronism
3. Be able to define imaging methods used for endocrine system.
4. Be able to list the treatment methods used in endocrine system diseases.Specifically pharmacokinetic features of insulins nd oral antihyperglycemic agents, treatment algorhytms for Type 2 diabetes, farmacokinetic features of corticosteroids, Thyroid hormones, antithyroid hormones, medications used for treatment of acromegaly, Cushing disease, hypogonadism, contraseption, menopause, osteoporisis,
5. Be able to list the effects of drugs used in the treatment of endocrine system diseases, their mechanism of action, pharmacokinetics, side effects and drug interactions.

Teaching Methods:	37: Computer-Internet Supported Instruction, 9: Lecture Method
Assessment Methods:	A: Traditional Written Exam

Course Outline

Order	Subjects	Preliminary Work
1	Pathology of Thyroid disease, Basics of thyroid function testsclinical features and treatment of hypothyroidism, thyroiditis, iodine deficiency, hyperthyroidism, thyroid cancer. Radiological (Ultrasound and scan) features of thyroiditis, thyroid nodules, Graves disease, toxic and non-toxic nodular disease.	none
2	Macroscopic and microscopic features of pituitary disease, interpretation of anterior and posterior pituitary functions, review of pitruitary hormone changes and correlation with hypothalamic hormones and end hormones, concept of macroprolactinemia, Stalk effect and hook effects for interpretation of prolactin elevation, clinicali lab and MR features of acromegaly, Cushing disease, TSH secreting tumors and prolactinoma. Diagnosis , differential diagnosis of pituitary tumors. Radiological features of Pituitary tumors, empty sella, hypophysitis,Hypopituitarism, diabetes incipitus, clinical features, treatment	none
3	Macroscopic and microscopic anatomic changes in various parathyroid disease, Approach to hypercalcemia and hypocalcemia. Clinical, lab and radiological features of primary hyperparathyroidism, osteoporosis, hypoparathyroidism, end stage renal disease. Clinical and lab features of MEN syndromes. Interpretation of bone mineral density, Management of vitamin D deficincy	none
4	Clinical features of type 1 and type 2 diabetes, the importance of diabetes... diagnosİs of diabetes mellitus type 1, type 2 gestational diabetes, the importance of glycosylated hemoglobin and oral glucose tolerance test. The macroscopic and microscopic anatomic features of diabetes, autoimmune development, resistance to insulin, polycystic ovary syndrome, metabolic syndrome. Acute and chronic complications of type diabetes- prevention and treatment. Prevention or Cardiovascular complications in type 2 diabetes. The pharmacokinetic features of insulins, how to establish an insulin treatment. The medications used for type 2 diabetes: treatment effects and adverse effects. The treatment algorithm in type 2 diabetes. Hypoglycemia, prevention and treatment. Non-diabetic hypoglycemia	NONE
5	Macroscopic and microscopic anatomic changes in adrenal disease. Review of hypothalamus, pituitary and adrenal gland axis. Symptoms of adrenal insufficiency, clinical features, laboratory findings, diagnosis and treatment. Review of mineralocorticoid and glucocorticoid actions of steroids. Cushing’s syndrome: screening, diagnosis, identification of the hypersecretion site. Secondary hypertension: primary hyperaldosteronism, pheochromocytoma	none

Resources

Patology: Vinay Kumar, Abul K. Abbas, Nelson Fausto, Richard Mitchell: Robbins Basic Pathology. 10 th ed. Saunders/Elsevier Edward C. Klatt: Robbins and Cotran Atlas of Pathology. 2nd ed. Saunders. online websites( Pathology outlines vb) lecture notes:ppt Pharmacology : 1.Kayaalp, SO: Rasyonel Tedavi Yönünden Tıbbi Farmakoloji, Ankara. 2.Hardman JG, Limbird LE, Eds.: Goodman and Gilman’s The Pharmacological Basis of Therapeutics, New York. 3.Katzung & Trevor: Farmakoloji, Ankara. Microbiyoloji: Microbiology: An Introduction (11th Edition), Gerard J. Tortora Internal medicine: Harrison Internal Medicine-İç hastalıkları Ders kitabı Uptodate database Greenspan : basiz and clinical endocrinology presentation notes-ppt Surgery: : schwartz principles of general surgery 10th edition Radiology and Pediatrics: Presentation notes-PPT slides

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Course Contribution to Program Qualifications

Course Contribution to Program Qualifications
No	Program Qualification	Contribution Level
No	Program Qualification	1	2	3	4	5
1	PQ1: Knows the morphological and functional normal and abnormal structure of human body.
2	PQ2: Knows the essential ways of determining the underlying causes of the pathologies with basic scientific approaches and the diagnoses of illnesses and disorders.
3	PQ3: Knows the reasons for illnesses, the ways of protection, and the methods of promotion and improvement of public health.
4	PQ4: Knows the methods of advancing his/her knowledge about health and its practice.
5	PQ5: Accesses, interprets and applies the advanced interdisciplinary information related to health.
6	PQ6: Performs a complete clinical examination of the human body, both morphologically and functionally and defines the problems.
7	PQ7: Interprets examination data for diagnoses, compares with clinical data, and provides solutions.
8	PQ8: Selects and applies appropriate tools for promotion and improvement of individual and public health.
9	PQ9: Plans and conducts an advanced study of health independently.
10	PQ10: Takes responsibility individually and as a team member to solve the problems encountered in the promotion and improvement of individual and public health.
11	PQ11: Takes responsibility for any intervention on the human body for the diagnosis and treatment.
12	PQ12: Determines personal learning requirements and decides and develops a positive lifelong learning attitude.
13	PQ13: Evaluates the information gained in the field of health with a critical approach.
14	PQ14: Informs the patient, the relevant people and institutions, and the public about the health problem and conveys recommendations of solutions in writing and/or verbally.
15	PQ15: Shares their recommendations on promotion and improvement of health with interdisciplinary experts by supporting with data.
16	PQ16: Uses English at least at the General Level of European Language Portfolio B1, follows resources in his/her field and communicates.
17	PQ17: Uses computer software, information, and communication technologies at least at the Advanced Level of European Computer Operating License.
18	PQ18: Acts in accordance with social, scientific, cultural and ethical values in the stages of obtaining, interpreting, applying and announcing the data related to the field of health.
19	PQ19: Develops strategy, policy and implementation plans on health issues and evaluate the results obtained the framework of quality processes.
20	PQ20: Systematically shares his/her works on promoting and improving health with quantitative and qualitative data and interdisciplinary experts.
21	PQ21: Has sufficient awareness on occupational health and safety issues.

Assessment Methods

Contribution Level	Absolute Evaluation
Rate of Midterm Exam to Success		60
Rate of Final Exam to Success		40
Total		100

ECTS / Workload Table
Activities	Number of	Duration(Hour)	Total Workload(Hour)
Course Hours	72	1	72
Guided Problem Solving	14	1	14
Resolution of Homework Problems and Submission as a Report	3	2	6
Term Project	0	0	0
Presentation of Project / Seminar	0	0	0
Quiz	0	0	0
Midterm Exam	0	0	0
General Exam	35	3	105
Performance Task, Maintenance Plan	0	0	0
Total Workload(Hour)			197
*Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30=(197/30)**			7
ECTS of the course: 30 hours of work is counted as 1 ECTS credit.

Detail Informations of the Course