Ders Detayı
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| LIVER BIOCHEMISTRY - II | - | Fall Semester | 2+0 | 2 | 6 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Third Cycle (Doctorate Degree) |
| Course Type | Elective |
| Course Coordinator | Assist.Prof. Çağrı ÇAKICI |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assist.Prof. Çağrı ÇAKICI, Assist.Prof. Derya CANSIZ |
| Assistant(s) | |
| Aim | To learn the biochemistry of the liver in an advanced level and to gain detailed knowledge on liver tests . |
| Course Content | This course contains; 1- Biochemical functions of the liver,2- Altering diseases liver function tests,3- Bilirubin metabolism,4- Bile acid structure and function,5- Synthesized proteins in the liver and functions,6- Affected enzymes in liver diseases Synthesis of,7- Liver tests which measure the ability,8- Hepatic nitrogen metabolism,9- Liver cell destruction tests showing,10- Cholestasis of the tests,11- hepatic metabolism of ammonia,12- liver and clotting factors,13- Liver cancer markers,14- Protein synthesis in liver. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| At the end of the course, the student will be able to; | ||
| 1-Question the liver function test | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Examine the liver function tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Question relationship of the coagulation test and liver | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4.Question the detoxification in the liver | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.5.Question ammonia, urea and encephalopathy | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2- Compares enzyme related to liver | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Question aminotransferases | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Analyse phosphatases | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Debate gamma-glutamyltransferase | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3- Compare hepatitis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4- Compares liver dysfunction tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1.Analyse conjugated tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Distinguish biosynthetic capacity of liver | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4.Debate liver cancer marker | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Question the effect of tranquilizers and some antibiotics | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6-Reach the printed and electronic information sources | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7-Explains related data of field and teach these values | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8-Evaluate the quality process in accordance with the results obtained | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2. Distinguish the little sensitivity liver function tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3. Question 5’- Nucleotidase | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1. Interpret hepatitis A tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2. Analyse hepatitis B tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3. Question hepatitis C tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4. Distinguish hepatitis D and E tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3. Demonstrate cholestasis tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5 –Can compare drug-induced liver tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2. Distinguish lipid-lowering medication | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3. Demonstrate antimicrobial drugs | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4. Question anticonvulsant, anesthetic and antineoplastic agents | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.5. Question industrial agents | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | 1- Biochemical functions of the liver | 1, 2 |
| 2 | 2- Altering diseases liver function tests | 1, 2 |
| 3 | 3- Bilirubin metabolism | 1, 2 |
| 4 | 4- Bile acid structure and function | 1, 2 |
| 5 | 5- Synthesized proteins in the liver and functions | 1, 2 |
| 6 | 6- Affected enzymes in liver diseases Synthesis of | 1, 2 |
| 7 | 7- Liver tests which measure the ability | 1, 2 |
| 8 | 8- Hepatic nitrogen metabolism | 1, 2 |
| 9 | 9- Liver cell destruction tests showing | 1, 2 |
| 10 | 10- Cholestasis of the tests | 1, 2 |
| 11 | 11- hepatic metabolism of ammonia | 1, 2 |
| 12 | 12- liver and clotting factors | 1, 2 |
| 13 | 13- Liver cancer markers | 1, 2 |
| 14 | 14- Protein synthesis in liver | 1, 2 |
| Resources |
| 1) Published books of Prof.Dr.Nesrin Emekli and Assoc.Prof.Dr.Türkan Yiğitbaşı Biochemistry Lab Book For Students(Doç.Dr.Türkan Yiğitbaşı,Prof.Dr.Nesrin Emekli)Medipol Üniversitesi Yayınları 2) Henry's Clinical Diagnosis and Management by Laboratory Methods (Mc Pherson.Pıncus) |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Defines macro and micromolecules in cell and body fluids at an advanced level. | X | |||||
| 2 | Knows how to store and protect the material to be analyzed. | X | |||||
| 3 | Knows how to identify molecules found in cells and body fluids. | X | |||||
| 4 | Knows the principles of technologies to be used for routine and research purposes. | X | |||||
| 5 | Knows how to evaluate the results of the study, interprets and questions. | X | |||||
| 6 | Knows how to use field-specific tools and equipment | X | |||||
| 7 | Knows how to access and interpret field-specific resources and information | X | |||||
| 8 | Shares information with disciplines related to the field | X | |||||
| 9 | Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals. | X | |||||
| 10 | Solves a scientific and technical problem, knows where to get help. | X | |||||
| 11 | Takes responsibility in joint scientific studies, contributes and works in harmony. | X | |||||
| 12 | Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field. | X | |||||
| 13 | Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially. | ||||||
| 14 | Can take part in management activities, evaluate the results obtained to improve quality | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 2 | 28 | |||
| Guided Problem Solving | 14 | 2 | 28 | |||
| Resolution of Homework Problems and Submission as a Report | 5 | 10 | 50 | |||
| Term Project | 2 | 5 | 10 | |||
| Presentation of Project / Seminar | 2 | 1 | 2 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 20 | 20 | |||
| General Exam | 1 | 30 | 30 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 168 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(168/30) | 6 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| LIVER BIOCHEMISTRY - II | - | Fall Semester | 2+0 | 2 | 6 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Third Cycle (Doctorate Degree) |
| Course Type | Elective |
| Course Coordinator | Assist.Prof. Çağrı ÇAKICI |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assist.Prof. Çağrı ÇAKICI, Assist.Prof. Derya CANSIZ |
| Assistant(s) | |
| Aim | To learn the biochemistry of the liver in an advanced level and to gain detailed knowledge on liver tests . |
| Course Content | This course contains; 1- Biochemical functions of the liver,2- Altering diseases liver function tests,3- Bilirubin metabolism,4- Bile acid structure and function,5- Synthesized proteins in the liver and functions,6- Affected enzymes in liver diseases Synthesis of,7- Liver tests which measure the ability,8- Hepatic nitrogen metabolism,9- Liver cell destruction tests showing,10- Cholestasis of the tests,11- hepatic metabolism of ammonia,12- liver and clotting factors,13- Liver cancer markers,14- Protein synthesis in liver. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| At the end of the course, the student will be able to; | ||
| 1-Question the liver function test | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Examine the liver function tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Question relationship of the coagulation test and liver | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4.Question the detoxification in the liver | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.5.Question ammonia, urea and encephalopathy | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2- Compares enzyme related to liver | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Question aminotransferases | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Analyse phosphatases | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Debate gamma-glutamyltransferase | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3- Compare hepatitis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4- Compares liver dysfunction tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1.Analyse conjugated tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Distinguish biosynthetic capacity of liver | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4.Debate liver cancer marker | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Question the effect of tranquilizers and some antibiotics | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6-Reach the printed and electronic information sources | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7-Explains related data of field and teach these values | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8-Evaluate the quality process in accordance with the results obtained | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2. Distinguish the little sensitivity liver function tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3. Question 5’- Nucleotidase | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1. Interpret hepatitis A tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2. Analyse hepatitis B tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3. Question hepatitis C tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4. Distinguish hepatitis D and E tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3. Demonstrate cholestasis tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5 –Can compare drug-induced liver tests | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2. Distinguish lipid-lowering medication | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3. Demonstrate antimicrobial drugs | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4. Question anticonvulsant, anesthetic and antineoplastic agents | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.5. Question industrial agents | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | 1- Biochemical functions of the liver | 1, 2 |
| 2 | 2- Altering diseases liver function tests | 1, 2 |
| 3 | 3- Bilirubin metabolism | 1, 2 |
| 4 | 4- Bile acid structure and function | 1, 2 |
| 5 | 5- Synthesized proteins in the liver and functions | 1, 2 |
| 6 | 6- Affected enzymes in liver diseases Synthesis of | 1, 2 |
| 7 | 7- Liver tests which measure the ability | 1, 2 |
| 8 | 8- Hepatic nitrogen metabolism | 1, 2 |
| 9 | 9- Liver cell destruction tests showing | 1, 2 |
| 10 | 10- Cholestasis of the tests | 1, 2 |
| 11 | 11- hepatic metabolism of ammonia | 1, 2 |
| 12 | 12- liver and clotting factors | 1, 2 |
| 13 | 13- Liver cancer markers | 1, 2 |
| 14 | 14- Protein synthesis in liver | 1, 2 |
| Resources |
| 1) Published books of Prof.Dr.Nesrin Emekli and Assoc.Prof.Dr.Türkan Yiğitbaşı Biochemistry Lab Book For Students(Doç.Dr.Türkan Yiğitbaşı,Prof.Dr.Nesrin Emekli)Medipol Üniversitesi Yayınları 2) Henry's Clinical Diagnosis and Management by Laboratory Methods (Mc Pherson.Pıncus) |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Defines macro and micromolecules in cell and body fluids at an advanced level. | X | |||||
| 2 | Knows how to store and protect the material to be analyzed. | X | |||||
| 3 | Knows how to identify molecules found in cells and body fluids. | X | |||||
| 4 | Knows the principles of technologies to be used for routine and research purposes. | X | |||||
| 5 | Knows how to evaluate the results of the study, interprets and questions. | X | |||||
| 6 | Knows how to use field-specific tools and equipment | X | |||||
| 7 | Knows how to access and interpret field-specific resources and information | X | |||||
| 8 | Shares information with disciplines related to the field | X | |||||
| 9 | Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals. | X | |||||
| 10 | Solves a scientific and technical problem, knows where to get help. | X | |||||
| 11 | Takes responsibility in joint scientific studies, contributes and works in harmony. | X | |||||
| 12 | Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field. | X | |||||
| 13 | Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially. | ||||||
| 14 | Can take part in management activities, evaluate the results obtained to improve quality | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |