Ders Detayı
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| BASIC TERMS in BIOCHEMISTRY | - | Fall Semester | 3+0 | 3 | 10 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Third Cycle (Doctorate Degree) |
| Course Type | Required |
| Course Coordinator | |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assist.Prof. Çağrı ÇAKICI, Assist.Prof. Derya CANSIZ |
| Assistant(s) | |
| Aim | To describe the structure, organisation and functions of biochemistry. |
| Course Content | This course contains; The structure of macromolecules in diet,The digestion, absorption and the transport of macromolecules in diet,The metabolism of carbohydrates,The metabolism of lipids,Amino acid metabolism,The structure and the metabolism of the proteins,Enzymes and enzyme reactions,The clinical importance of the enzymes,Vitamins and their role in metabolism,Minerals and their role in reactions,Water, body fluids and buffer systems,Variance before the biochemical analysis,Biochemical solutions,Waste and contaminants in biochemistry laboratories. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-To be able to question the molecular properties of macromolecules taken in the diet and their relationships with each other. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Defines the structure and properties of carbohydrates. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Defines the structure and properties of lipids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Defines the structural properties of dietary amino acids and proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Evaluates the passage of dietary macro and micro molecules from the digestive tract into the blood. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1..Solve the important structure of carbohydrates within the cell and cell membrane. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Solve the important lipids within the cell and cell membrane. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Question the proteins and amino acids within the cell and cell membrane. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Interrogates the relationship of the endocrine system with macromolecules in digestion. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Compare the macro and micro minerals in the metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.5.Compare the effect of hormone, enzyme and vitamins on the proteins,carbohydrates and lipids. | 13, 14, 19, 9 | |
| 3.1.Question the metabolic fate of glucose. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3.Question the de nova synthesis of glucose and fatty acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.5.Interpret the proteins in the energy production. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Can question the metabolic pathway of lipids. | 14, 16, 19, 9 | |
| 4.3.Questions the importance of apoproteins in lipid metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.6.Questions the causes of lipid metabolism disorders. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5-Can question the structure and metabolic pathway of amino acids and proteins. | 13, 14, 16, 19, 9 | |
| 5.1.Defines polar, nonpolar, aliphatic and cyclic amino acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Explains the classification of amino acids according to their side chains. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.5.Question the fate of dietary proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6-Interrogates enzyme reactions. | 13, 14, 16, 19, 9 | |
| 6.3.Defines the factors affecting enzyme reactions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.4.Defines enzyme inhibitors, activators. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.5.Explains the classification and nomenclature of enzymes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.6.Defines the functions of metal ions in enzyme reactions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7-question the structure of vitamins and their place in energy production | 13, 14, 16, 19, 9 | |
| 7.1.Explains the structural properties of various vitamins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8-Questions the place of minerals in metabolic reactions and energy production. | 13, 14, 16, 19, 9 | |
| 8.1.questions the absorption, transport and storage of minerals that are indispensable for the body. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.2.Explains the place of macro and micro minerals in metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.Explains the properties of body fluids and acid-base balance. | 13, 14, 16, 19, 9 | |
| 9.1.Explains the molecular properties of water to prepare water of various purity. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.2.Describes how body fluid compartments are regulated. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.4.Explains the importance of body fluids such as urine, cerebrosipinal fluid, saliva. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.6.Explains the regulation of hydrogen ion buffer systems. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.Questions the variables before analysis in biochemical analyses. | 13, 16, 19, 9 | |
| 11-Questions the concepts of solution and concentration. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12-Questions the rules and security of the biochemistry laboratory. | 10, 11, 14, 16, 19, 6, 9 | A, D, E |
| 12.1.Defines the importance of environmental conditions and laboratory rules in analyses. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4. Can question glycaemic control. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1. Questions the properties and importance of fatty acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2. Questions the importance of lipoproteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4. Explains esterifying alcohols with fatty acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.5. Interpret hormonal control in lipid metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.7. Questions the importance of fatty acids in energy metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4. Defines modifications of amino acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.6. Explains the polymorphism in protein structure. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.7. Explains urea synthesis and its importance. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.1. Defines enzyme substrate product relationship. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.2. Explains the catalytic site of enzymes, coenzyme, apoenzyme relationship. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.7. Explains the mechanism of enzyme reactions in drug production. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.8. Explain the regulation of enzyme reactions, Michaelis-Menten equilibrium, lineweavr-Burk transformation. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.9. Defines reversible inhibition, allosteric inhibitors, covalent modification, Ca2+ calmodulin, monomeric G proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.2. Defines the place of various vitamins in metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.3. Defines the functions of various vitamins in energy production. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.4. Questions the situations encountered in vitamin deficiency. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.3. Questions the minerals that are important in energy metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.4. Explains the toxic levels of vital minerals. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.5. Explains the use of minerals in treatment and measurement methods. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.3. Explains the importance of water in the regulation of blood and cell volume, water balance disorders. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.5. Questions acid-base balance, pK value, pH notion. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.1. Describes how to collect samples for biochemical analyses. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.2. Explains the unchanging and changing factors in analyses. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.3. Describes the properties of tubes and anticoagulants taken for analysis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.4. Question preanalytical errors in various biochemical analyses. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 11.1. Defines the concepts of solution, solubility, concentration. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 11.2. Defines the concepts of normality, molarity, molality, osmolality, osmolarity. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 11.3. Uses solutions used in qualitative and quantitative analysis methods. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 11.4. Explains that the reliability of the analysis results is related to the correct preparation of solutions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.2. Defines individual safe working rules in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.3. Defines the rules of working with chemicals in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.4. Defines the rules of working with carcinogenic substances in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.5. Defines how biological safety is ensured in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.6. Identifies hazardous and special wastes in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.7. Explains the principles of waste and disposal in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.8. Explains how to dispose of biological wastes, hazardous and non-hazardous chemical wastes, radioactive wastes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 13: Case Study Method, 14: Self Study Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | The structure of macromolecules in diet | 1,2,3,4,5,6,10,13 |
| 2 | The digestion, absorption and the transport of macromolecules in diet | 1,2,3,4,5,6,10,13 |
| 3 | The metabolism of carbohydrates | 1,2,3,4,5,6,10,13 |
| 4 | The metabolism of lipids | 1,2,3,4,5,6,10,13 |
| 5 | Amino acid metabolism | 1,2,3,4,5,6,10,13 |
| 6 | The structure and the metabolism of the proteins | 1,2,3,4,5,6,10,13 |
| 7 | Enzymes and enzyme reactions | 1,2,3,4,5,6,10,13 |
| 8 | The clinical importance of the enzymes | 1,2,3,4,5,6,10,13 |
| 9 | Vitamins and their role in metabolism | 1,2,3,4,5,6,10,13 |
| 10 | Minerals and their role in reactions | 1,2,3,4,5,6,7,10,13 |
| 11 | Water, body fluids and buffer systems | 1,2,3,4,5,6,8,10,12,13 |
| 12 | Variance before the biochemical analysis | 1,2,3,4,5,6,9,10,13 |
| 13 | Biochemical solutions | 1,2,3,4,5,6,9,10,11,13 |
| 14 | Waste and contaminants in biochemistry laboratories | 1,2,3,4,5,6,9,10,11,13 |
| Resources |
| 1) Nelson DL ve Cox MM.Lehninger Biyokimyanın İlkeleri. Çeviri Ed. Kılıç N. Palme Yayıncılık, 2005. 2) Lieberman M, Marks AD. Marks’ Basic medical biochemistry 3. Baskı, Lippincott Williams &Wilkins, 2010. 3) Bishop ML, Fody EP,Schoeff LE. Clinical Chemistry 7.Baskı,s.323-334. Lippincott, 2013. 4) Henry’s Clinical Diagnosisand Management by Laboratory Method,.22.Baskı,Eds.Pherson RA, Pincus MR,Elsevier-Saunders, 2011. 5) Yiğitbaşı T, Emekli N. Biyokimya Laboratuarı. İstanbul Medipol Üniversitesi,Yayınları, Akademi Basın Yayın, İstanbul 2013. 6) Emekli N. Temel ve Uygulamalı Biyokimya, 4.Baskı.Akademi Basın Yayın, İstanbul 2006. 7) Kılınç M. Eser elementler. İçinde Klinik Biyokimya Eds. Emekli&Yiğitbaşı, Medipol Üniversitesi Yayınları, Akademi Matbaası, 2015. 8) Alturfan AA. Su biyokimyası. İçinde: Klinik Biyokimya Eds. Emekli & Yiğitbaşı, Medipol Üniversitesi Yayınları, Akademi Matbaası, 2015. 9) Ülfer G ve Emekli N. Klinik laboratuvar kuralları güvenliği ve referans değerler. İçinde: Klinik Biyokimya Eds. 10) Emekli & Yiğitbaşı, Medipol Üniversitesi Yayınları, Akademi Matbaası, 2015. 11) Yarat A. Biyokimyada çözelti ve konsantrasyon kavramları. İçinde: Klinik Biyokimya Eds. Emekli & Yiğitbaşı, Medipol Üniversitesi Yayınları, Akademi Matbaası, 2015. 12) Ceran Ö . Kan gazları ve tampon sistemler. . İçinde: Klinik Biyokimya Eds. Emekli & Yiğitbaşı, Medipol Üniversitesi Yayınları, Akademi Matbaası, 2015. 13) Montgomery, Conway, Spector, Chappel. Biyokimya Çeviri Ed. Altan N. Palme yayıncılık,2000 |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Defines macro and micromolecules in cell and body fluids at an advanced level. | X | |||||
| 2 | Knows how to store and protect the material to be analyzed. | X | |||||
| 2 | Knows how to store and protect the material to be analyzed. | X | |||||
| 3 | Knows how to identify molecules found in cells and body fluids. | X | |||||
| 4 | Knows the principles of technologies to be used for routine and research purposes. | X | |||||
| 5 | Knows how to evaluate the results of the study, interprets and questions. | X | |||||
| 6 | Knows how to use field-specific tools and equipment | X | |||||
| 7 | Knows how to access and interpret field-specific resources and information | X | |||||
| 8 | Shares information with disciplines related to the field | X | |||||
| 9 | Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals. | X | |||||
| 10 | Solves a scientific and technical problem, knows where to get help. | X | |||||
| 11 | Takes responsibility in joint scientific studies, contributes and works in harmony. | X | |||||
| 12 | Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field. | X | |||||
| 13 | Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially. | X | |||||
| 14 | Can take part in management activities, evaluate the results obtained to improve quality | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 3 | 42 | |||
| Guided Problem Solving | 14 | 3 | 42 | |||
| Resolution of Homework Problems and Submission as a Report | 8 | 10 | 80 | |||
| Term Project | 5 | 10 | 50 | |||
| Presentation of Project / Seminar | 2 | 5 | 10 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 35 | 35 | |||
| General Exam | 1 | 40 | 40 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 299 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(299/30) | 10 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| BASIC TERMS in BIOCHEMISTRY | - | Fall Semester | 3+0 | 3 | 10 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Third Cycle (Doctorate Degree) |
| Course Type | Required |
| Course Coordinator | |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assist.Prof. Çağrı ÇAKICI, Assist.Prof. Derya CANSIZ |
| Assistant(s) | |
| Aim | To describe the structure, organisation and functions of biochemistry. |
| Course Content | This course contains; The structure of macromolecules in diet,The digestion, absorption and the transport of macromolecules in diet,The metabolism of carbohydrates,The metabolism of lipids,Amino acid metabolism,The structure and the metabolism of the proteins,Enzymes and enzyme reactions,The clinical importance of the enzymes,Vitamins and their role in metabolism,Minerals and their role in reactions,Water, body fluids and buffer systems,Variance before the biochemical analysis,Biochemical solutions,Waste and contaminants in biochemistry laboratories. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-To be able to question the molecular properties of macromolecules taken in the diet and their relationships with each other. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Defines the structure and properties of carbohydrates. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Defines the structure and properties of lipids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Defines the structural properties of dietary amino acids and proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Evaluates the passage of dietary macro and micro molecules from the digestive tract into the blood. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1..Solve the important structure of carbohydrates within the cell and cell membrane. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Solve the important lipids within the cell and cell membrane. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Question the proteins and amino acids within the cell and cell membrane. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Interrogates the relationship of the endocrine system with macromolecules in digestion. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Compare the macro and micro minerals in the metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.5.Compare the effect of hormone, enzyme and vitamins on the proteins,carbohydrates and lipids. | 13, 14, 19, 9 | |
| 3.1.Question the metabolic fate of glucose. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3.Question the de nova synthesis of glucose and fatty acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.5.Interpret the proteins in the energy production. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Can question the metabolic pathway of lipids. | 14, 16, 19, 9 | |
| 4.3.Questions the importance of apoproteins in lipid metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.6.Questions the causes of lipid metabolism disorders. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5-Can question the structure and metabolic pathway of amino acids and proteins. | 13, 14, 16, 19, 9 | |
| 5.1.Defines polar, nonpolar, aliphatic and cyclic amino acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Explains the classification of amino acids according to their side chains. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.5.Question the fate of dietary proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6-Interrogates enzyme reactions. | 13, 14, 16, 19, 9 | |
| 6.3.Defines the factors affecting enzyme reactions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.4.Defines enzyme inhibitors, activators. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.5.Explains the classification and nomenclature of enzymes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.6.Defines the functions of metal ions in enzyme reactions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7-question the structure of vitamins and their place in energy production | 13, 14, 16, 19, 9 | |
| 7.1.Explains the structural properties of various vitamins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8-Questions the place of minerals in metabolic reactions and energy production. | 13, 14, 16, 19, 9 | |
| 8.1.questions the absorption, transport and storage of minerals that are indispensable for the body. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.2.Explains the place of macro and micro minerals in metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.Explains the properties of body fluids and acid-base balance. | 13, 14, 16, 19, 9 | |
| 9.1.Explains the molecular properties of water to prepare water of various purity. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.2.Describes how body fluid compartments are regulated. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.4.Explains the importance of body fluids such as urine, cerebrosipinal fluid, saliva. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.6.Explains the regulation of hydrogen ion buffer systems. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.Questions the variables before analysis in biochemical analyses. | 13, 16, 19, 9 | |
| 11-Questions the concepts of solution and concentration. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12-Questions the rules and security of the biochemistry laboratory. | 10, 11, 14, 16, 19, 6, 9 | A, D, E |
| 12.1.Defines the importance of environmental conditions and laboratory rules in analyses. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4. Can question glycaemic control. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1. Questions the properties and importance of fatty acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2. Questions the importance of lipoproteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4. Explains esterifying alcohols with fatty acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.5. Interpret hormonal control in lipid metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.7. Questions the importance of fatty acids in energy metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4. Defines modifications of amino acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.6. Explains the polymorphism in protein structure. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.7. Explains urea synthesis and its importance. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.1. Defines enzyme substrate product relationship. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.2. Explains the catalytic site of enzymes, coenzyme, apoenzyme relationship. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.7. Explains the mechanism of enzyme reactions in drug production. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.8. Explain the regulation of enzyme reactions, Michaelis-Menten equilibrium, lineweavr-Burk transformation. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.9. Defines reversible inhibition, allosteric inhibitors, covalent modification, Ca2+ calmodulin, monomeric G proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.2. Defines the place of various vitamins in metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.3. Defines the functions of various vitamins in energy production. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.4. Questions the situations encountered in vitamin deficiency. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.3. Questions the minerals that are important in energy metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.4. Explains the toxic levels of vital minerals. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.5. Explains the use of minerals in treatment and measurement methods. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.3. Explains the importance of water in the regulation of blood and cell volume, water balance disorders. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.5. Questions acid-base balance, pK value, pH notion. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.1. Describes how to collect samples for biochemical analyses. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.2. Explains the unchanging and changing factors in analyses. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.3. Describes the properties of tubes and anticoagulants taken for analysis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.4. Question preanalytical errors in various biochemical analyses. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 11.1. Defines the concepts of solution, solubility, concentration. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 11.2. Defines the concepts of normality, molarity, molality, osmolality, osmolarity. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 11.3. Uses solutions used in qualitative and quantitative analysis methods. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 11.4. Explains that the reliability of the analysis results is related to the correct preparation of solutions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.2. Defines individual safe working rules in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.3. Defines the rules of working with chemicals in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.4. Defines the rules of working with carcinogenic substances in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.5. Defines how biological safety is ensured in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.6. Identifies hazardous and special wastes in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.7. Explains the principles of waste and disposal in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12.8. Explains how to dispose of biological wastes, hazardous and non-hazardous chemical wastes, radioactive wastes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 13: Case Study Method, 14: Self Study Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | The structure of macromolecules in diet | 1,2,3,4,5,6,10,13 |
| 2 | The digestion, absorption and the transport of macromolecules in diet | 1,2,3,4,5,6,10,13 |
| 3 | The metabolism of carbohydrates | 1,2,3,4,5,6,10,13 |
| 4 | The metabolism of lipids | 1,2,3,4,5,6,10,13 |
| 5 | Amino acid metabolism | 1,2,3,4,5,6,10,13 |
| 6 | The structure and the metabolism of the proteins | 1,2,3,4,5,6,10,13 |
| 7 | Enzymes and enzyme reactions | 1,2,3,4,5,6,10,13 |
| 8 | The clinical importance of the enzymes | 1,2,3,4,5,6,10,13 |
| 9 | Vitamins and their role in metabolism | 1,2,3,4,5,6,10,13 |
| 10 | Minerals and their role in reactions | 1,2,3,4,5,6,7,10,13 |
| 11 | Water, body fluids and buffer systems | 1,2,3,4,5,6,8,10,12,13 |
| 12 | Variance before the biochemical analysis | 1,2,3,4,5,6,9,10,13 |
| 13 | Biochemical solutions | 1,2,3,4,5,6,9,10,11,13 |
| 14 | Waste and contaminants in biochemistry laboratories | 1,2,3,4,5,6,9,10,11,13 |
| Resources |
| 1) Nelson DL ve Cox MM.Lehninger Biyokimyanın İlkeleri. Çeviri Ed. Kılıç N. Palme Yayıncılık, 2005. 2) Lieberman M, Marks AD. Marks’ Basic medical biochemistry 3. Baskı, Lippincott Williams &Wilkins, 2010. 3) Bishop ML, Fody EP,Schoeff LE. Clinical Chemistry 7.Baskı,s.323-334. Lippincott, 2013. 4) Henry’s Clinical Diagnosisand Management by Laboratory Method,.22.Baskı,Eds.Pherson RA, Pincus MR,Elsevier-Saunders, 2011. 5) Yiğitbaşı T, Emekli N. Biyokimya Laboratuarı. İstanbul Medipol Üniversitesi,Yayınları, Akademi Basın Yayın, İstanbul 2013. 6) Emekli N. Temel ve Uygulamalı Biyokimya, 4.Baskı.Akademi Basın Yayın, İstanbul 2006. 7) Kılınç M. Eser elementler. İçinde Klinik Biyokimya Eds. Emekli&Yiğitbaşı, Medipol Üniversitesi Yayınları, Akademi Matbaası, 2015. 8) Alturfan AA. Su biyokimyası. İçinde: Klinik Biyokimya Eds. Emekli & Yiğitbaşı, Medipol Üniversitesi Yayınları, Akademi Matbaası, 2015. 9) Ülfer G ve Emekli N. Klinik laboratuvar kuralları güvenliği ve referans değerler. İçinde: Klinik Biyokimya Eds. 10) Emekli & Yiğitbaşı, Medipol Üniversitesi Yayınları, Akademi Matbaası, 2015. 11) Yarat A. Biyokimyada çözelti ve konsantrasyon kavramları. İçinde: Klinik Biyokimya Eds. Emekli & Yiğitbaşı, Medipol Üniversitesi Yayınları, Akademi Matbaası, 2015. 12) Ceran Ö . Kan gazları ve tampon sistemler. . İçinde: Klinik Biyokimya Eds. Emekli & Yiğitbaşı, Medipol Üniversitesi Yayınları, Akademi Matbaası, 2015. 13) Montgomery, Conway, Spector, Chappel. Biyokimya Çeviri Ed. Altan N. Palme yayıncılık,2000 |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Defines macro and micromolecules in cell and body fluids at an advanced level. | X | |||||
| 2 | Knows how to store and protect the material to be analyzed. | X | |||||
| 2 | Knows how to store and protect the material to be analyzed. | X | |||||
| 3 | Knows how to identify molecules found in cells and body fluids. | X | |||||
| 4 | Knows the principles of technologies to be used for routine and research purposes. | X | |||||
| 5 | Knows how to evaluate the results of the study, interprets and questions. | X | |||||
| 6 | Knows how to use field-specific tools and equipment | X | |||||
| 7 | Knows how to access and interpret field-specific resources and information | X | |||||
| 8 | Shares information with disciplines related to the field | X | |||||
| 9 | Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals. | X | |||||
| 10 | Solves a scientific and technical problem, knows where to get help. | X | |||||
| 11 | Takes responsibility in joint scientific studies, contributes and works in harmony. | X | |||||
| 12 | Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field. | X | |||||
| 13 | Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially. | X | |||||
| 14 | Can take part in management activities, evaluate the results obtained to improve quality | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |