Ders Detayı
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| BONE BIOCHEMISTRY | - | Fall Semester | 2+0 | 2 | 5 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Third Cycle (Doctorate Degree) |
| Course Type | Elective |
| Course Coordinator | |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Mukaddes ÇOLAKOĞULLARI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER |
| Assistant(s) | |
| Aim | To teach advanced biochemical mechanisms about bone structure, bone metabolism and related diseases |
| Course Content | This course contains; Biochemical structure and properties of the bone,Mineral in bone structure,Proteins in bone structure,Osteoblasts,Osteoclasts,Laboratory markers of osteoblasts and osteoclasts,Metabolic bone and joint diseases,Osteoporosis,Osteomalasy,Rachitism,Parathyroid hormones and bone,Biochemicak biomarkers related to bone,Biochemical biomarkers in bone tumors,Clinical assessment of bone biomarkers. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-Question the biochemical properties of bone | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Explain minerals in bone structure | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Explain the mechanism of precise measurement of minerals active in bone structure | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Question the proteins in the bone structure | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4.Relate the collagen structure in bone with biochemical assessments | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Question the biochemical mechanisms of the osteoblasts in bone | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Evaluate osteoblast products in biochemical aspect | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Analyse the isoenzymes of alkaline phosphatase | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Questions the relation of between osteocalcin and procollagen and osteoblast. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3-Question the biochemical mechanisms of osteoclast activity | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.Identify the functions of osteoclasts | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2.Explain acid phosphatase function of the osteoclasts | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3.Explain the relation of osteoclast and hydroxyproline | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4.Osteoclast hydroxyllysine questions the relation of pyridinoline and deoxypyridinoline. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.5.Explains the laboratory evaluation of osteoclasite and osteoblast products. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Question the biochemistry of the metabolic bone and joint diseases | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4,1. Question the causes of osteoporosis and biochemical changes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Evaluate the genetic factors of osteoporosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3.Explain the principles of laboratory methods in osteoporosis and creative ideas can be determined for the better. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4.Explains the relation of nutrition and other factors and osteoprosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.5.Explains the mechanism of chemicals in the treatment of osteoporosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.6.Explains the biochemical differences between osteoporosis and osteomalacia. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.7.Explains biochemical markers and differences related to rickets. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5-Question the relationship of parathyroid hormones and the bone | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Explain the mechanism of parathyroid hormone and hypercalcemia | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Question primer and seconder hyperparathyroidism | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Explain the laboratory methods about parathyroid hormones | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4.Explains other mechanisms related to bone metabolism of parathyroid and thyroid hormones. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6-Question the biochemical assessments related to bone pathology | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.1.Evaluate clinical biomarkers of bone in clinics | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.2.Discusses biochemical markers in bone tumours and questions ideas for the better. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.3.Explain the biochemical assessment of bone biopsy | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2. Explain the relation of osteoblast and alkaline phosphatase | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.4. Explains bone-related enzymes and differential diagnosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Biochemical structure and properties of the bone | 1, 2, 3 |
| 2 | Mineral in bone structure | 1, 2, 3 |
| 3 | Proteins in bone structure | 1, 2, 3 |
| 4 | Osteoblasts | 1, 2, 3 |
| 5 | Osteoclasts | 1, 2, 3 |
| 6 | Laboratory markers of osteoblasts and osteoclasts | 1, 2, 3 |
| 7 | Metabolic bone and joint diseases | 1, 2, 3 |
| 8 | Osteoporosis | 1, 2, 3 |
| 9 | Osteomalasy | 1, 2, 3 |
| 10 | Rachitism | 1, 2, 3 |
| 11 | Parathyroid hormones and bone | 1, 2, 3 |
| 12 | Biochemicak biomarkers related to bone | 1, 2, 3 |
| 13 | Biochemical biomarkers in bone tumors | 1, 2, 3 |
| 14 | Clinical assessment of bone biomarkers | 1, 2, 3 |
| Resources |
| 1)Klinik Biyokimya Medipol Üniv. Yayınları,Eds.Emekli&Yiğitbaşı 2015 2)Henry's Clinical Diagnosis and Management by laboratory methods 3)Menapoz ve Osteoporoz, Eds.Erdoğan Ertüngealp&Hakan Seyisoğlu Ulusal menapoz ve osteoporoz, Derneği Yayınları 2000, İstanbul |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Defines macro and micromolecules in cell and body fluids at an advanced level. | X | |||||
| 2 | Knows how to store and protect the material to be analyzed. | X | |||||
| 3 | Knows how to identify molecules found in cells and body fluids. | X | |||||
| 4 | Knows the principles of technologies to be used for routine and research purposes. | X | |||||
| 5 | Knows how to evaluate the results of the study, interprets and questions. | X | |||||
| 6 | Knows how to use field-specific tools and equipment | X | |||||
| 7 | Knows how to access and interpret field-specific resources and information | X | |||||
| 8 | Shares information with disciplines related to the field | X | |||||
| 9 | Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals. | X | |||||
| 10 | Solves a scientific and technical problem, knows where to get help. | X | |||||
| 11 | Takes responsibility in joint scientific studies, contributes and works in harmony. | X | |||||
| 12 | Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field. | X | |||||
| 13 | Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially. | X | |||||
| 14 | Can take part in management activities, evaluate the results obtained to improve quality | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 15 | 2 | 30 | |||
| Guided Problem Solving | 15 | 5 | 75 | |||
| Resolution of Homework Problems and Submission as a Report | 0 | 0 | 0 | |||
| Term Project | 2 | 2 | 4 | |||
| Presentation of Project / Seminar | 2 | 1 | 2 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 3 | 3 | |||
| General Exam | 1 | 4 | 4 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 118 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(118/30) | 4 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| BONE BIOCHEMISTRY | - | Fall Semester | 2+0 | 2 | 5 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Third Cycle (Doctorate Degree) |
| Course Type | Elective |
| Course Coordinator | |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Mukaddes ÇOLAKOĞULLARI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER |
| Assistant(s) | |
| Aim | To teach advanced biochemical mechanisms about bone structure, bone metabolism and related diseases |
| Course Content | This course contains; Biochemical structure and properties of the bone,Mineral in bone structure,Proteins in bone structure,Osteoblasts,Osteoclasts,Laboratory markers of osteoblasts and osteoclasts,Metabolic bone and joint diseases,Osteoporosis,Osteomalasy,Rachitism,Parathyroid hormones and bone,Biochemicak biomarkers related to bone,Biochemical biomarkers in bone tumors,Clinical assessment of bone biomarkers. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-Question the biochemical properties of bone | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Explain minerals in bone structure | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Explain the mechanism of precise measurement of minerals active in bone structure | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Question the proteins in the bone structure | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4.Relate the collagen structure in bone with biochemical assessments | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Question the biochemical mechanisms of the osteoblasts in bone | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Evaluate osteoblast products in biochemical aspect | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Analyse the isoenzymes of alkaline phosphatase | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Questions the relation of between osteocalcin and procollagen and osteoblast. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3-Question the biochemical mechanisms of osteoclast activity | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.Identify the functions of osteoclasts | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2.Explain acid phosphatase function of the osteoclasts | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3.Explain the relation of osteoclast and hydroxyproline | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4.Osteoclast hydroxyllysine questions the relation of pyridinoline and deoxypyridinoline. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.5.Explains the laboratory evaluation of osteoclasite and osteoblast products. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Question the biochemistry of the metabolic bone and joint diseases | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4,1. Question the causes of osteoporosis and biochemical changes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Evaluate the genetic factors of osteoporosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3.Explain the principles of laboratory methods in osteoporosis and creative ideas can be determined for the better. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4.Explains the relation of nutrition and other factors and osteoprosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.5.Explains the mechanism of chemicals in the treatment of osteoporosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.6.Explains the biochemical differences between osteoporosis and osteomalacia. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.7.Explains biochemical markers and differences related to rickets. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5-Question the relationship of parathyroid hormones and the bone | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Explain the mechanism of parathyroid hormone and hypercalcemia | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Question primer and seconder hyperparathyroidism | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Explain the laboratory methods about parathyroid hormones | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4.Explains other mechanisms related to bone metabolism of parathyroid and thyroid hormones. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6-Question the biochemical assessments related to bone pathology | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.1.Evaluate clinical biomarkers of bone in clinics | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.2.Discusses biochemical markers in bone tumours and questions ideas for the better. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.3.Explain the biochemical assessment of bone biopsy | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2. Explain the relation of osteoblast and alkaline phosphatase | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.4. Explains bone-related enzymes and differential diagnosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Biochemical structure and properties of the bone | 1, 2, 3 |
| 2 | Mineral in bone structure | 1, 2, 3 |
| 3 | Proteins in bone structure | 1, 2, 3 |
| 4 | Osteoblasts | 1, 2, 3 |
| 5 | Osteoclasts | 1, 2, 3 |
| 6 | Laboratory markers of osteoblasts and osteoclasts | 1, 2, 3 |
| 7 | Metabolic bone and joint diseases | 1, 2, 3 |
| 8 | Osteoporosis | 1, 2, 3 |
| 9 | Osteomalasy | 1, 2, 3 |
| 10 | Rachitism | 1, 2, 3 |
| 11 | Parathyroid hormones and bone | 1, 2, 3 |
| 12 | Biochemicak biomarkers related to bone | 1, 2, 3 |
| 13 | Biochemical biomarkers in bone tumors | 1, 2, 3 |
| 14 | Clinical assessment of bone biomarkers | 1, 2, 3 |
| Resources |
| 1)Klinik Biyokimya Medipol Üniv. Yayınları,Eds.Emekli&Yiğitbaşı 2015 2)Henry's Clinical Diagnosis and Management by laboratory methods 3)Menapoz ve Osteoporoz, Eds.Erdoğan Ertüngealp&Hakan Seyisoğlu Ulusal menapoz ve osteoporoz, Derneği Yayınları 2000, İstanbul |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Defines macro and micromolecules in cell and body fluids at an advanced level. | X | |||||
| 2 | Knows how to store and protect the material to be analyzed. | X | |||||
| 3 | Knows how to identify molecules found in cells and body fluids. | X | |||||
| 4 | Knows the principles of technologies to be used for routine and research purposes. | X | |||||
| 5 | Knows how to evaluate the results of the study, interprets and questions. | X | |||||
| 6 | Knows how to use field-specific tools and equipment | X | |||||
| 7 | Knows how to access and interpret field-specific resources and information | X | |||||
| 8 | Shares information with disciplines related to the field | X | |||||
| 9 | Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals. | X | |||||
| 10 | Solves a scientific and technical problem, knows where to get help. | X | |||||
| 11 | Takes responsibility in joint scientific studies, contributes and works in harmony. | X | |||||
| 12 | Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field. | X | |||||
| 13 | Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially. | X | |||||
| 14 | Can take part in management activities, evaluate the results obtained to improve quality | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |