Ders Detayı
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| ATHEROSCLEROSIS BIOCHEMISTRY | - | Fall Semester | 2+0 | 2 | 6 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Third Cycle (Doctorate Degree) |
| Course Type | Elective |
| Course Coordinator | |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assoc.Prof. Mukaddes ÇOLAKOĞULLARI |
| Assistant(s) | |
| Aim | To question the biochemical reactions during atherosclerosis process, to add comments for the development of new methods and drug discovery |
| Course Content | This course contains; Biochemistry of the atherosclerosis,Molecular changes in normal and damaged endothelium,Development of acute arterial damage and thrombosis,Thrombocyctes and atherosclerosis,Tissue factor and atherosclerosis,Tissue factor inhibitors,Plasminogen activators in atherosclerotic plaques,Plasminogen inhibitors and atherosclerosis,Coagulation factors and atherosclerosis,Relationship of cholesterol and atherosclerosis,Lipoprotein (a) and atherosclerosis,Cytokines and atherosclerosis,Animal models of atherosclerosis,Laboratory approach to thrombosis risk. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| Explain biochemistry of the atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Question molecular changes related to the endothelium | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Question thrombosis in the damaged endothelium | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.Explain the relationship between atherosclerosis and thrombosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Discuss the relation of thrombosis with atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Explain the changes of thrombosis adhesion during atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Explains the relationship between thrombosis secretion and atherosclerosis development | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Explains the relationship between thrombosis agregation and atherosclerosis development | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.Question the development of tissue factor both in normal and atherosclerotic plaques | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3-Explains the relationship of the tissue factor and the atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.Question the development of tissue factor both in normal and atherosclerotic plaques | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Question the relationship of lipoprotein (a) and thrombosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.6.Determine new method and drugs to inhibit tissue factor and thrombosis relationship | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Question the relationship of atherosclerosis and fibrinolytic system | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1.Explain plasminogen activator and inhibitors with thrombosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Question the relationship of lipoprotein (a) and thrombosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3.Discuss the relationship of homocysteine with thrombosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5-Question the relationship cholesterol and thrombosis development | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Explain the relationship of LDL-C and HDL-C with thrombosis development | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Discuss the mechanism of cholesterol-lowering drugs | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6-Determine signalling pathways related to atherosclerotic process | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.1.Explain cytokine related atherosclerosis process | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.2.Explain markers related to atherosclerosis development | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.3.Develops new methods for the early diagnosis of atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7-Evaluate animal models related to atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.1.Explain animal models resistant to atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.2.Explain the transgenic animal models related to atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.3.Explains the relationship of Apo E and HDL relationship in animal models | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.4.Explain the atherosclerotic changes in transgenic animal models | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.5.Determine new ideas about animals models related to atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1. Explains the biochemical mechanism of atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4. Determines creative ideas, medications and methods to prevent endothelial damage | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2. Explain the arterial damage in animal models | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3. Explains how regulation is achieved in circulating tissue factor and thrombus formation. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.5. Questions the relationship of the tissue factor inhibitor and the atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4. Discover new method and drugs | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3. Determine drugs about cholesterol-related mechanisms | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Biochemistry of the atherosclerosis | 1, 2, 3, 4 |
| 2 | Molecular changes in normal and damaged endothelium | 1, 2, 3, 4 |
| 3 | Development of acute arterial damage and thrombosis | 1, 2, 3, 4 |
| 4 | Thrombocyctes and atherosclerosis | 1, 2, 3, 4 |
| 5 | Tissue factor and atherosclerosis | 1, 2, 3, 4 |
| 6 | Tissue factor inhibitors | 1, 2, 3, 4 |
| 7 | Plasminogen activators in atherosclerotic plaques | 1, 2, 3, 4 |
| 8 | Plasminogen inhibitors and atherosclerosis | 1, 2, 3, 4 |
| 9 | Coagulation factors and atherosclerosis | 1, 2, 3, 4 |
| 10 | Relationship of cholesterol and atherosclerosis | 1, 2, 3, 4 |
| 11 | Lipoprotein (a) and atherosclerosis | 1, 2, 3, 4 |
| 12 | Cytokines and atherosclerosis | 1, 2, 3, 4 |
| 13 | Animal models of atherosclerosis | 1, 2, 3, 4 |
| 14 | Laboratory approach to thrombosis risk | 1, 2, 3, 4 |
| Resources |
| 1)Williams Hematoloji (International Edition) 2)Wintrobe Hematoloji (International Edition) 3)Kartal N. Karademir B, Batırel S.Ateroskleroz Biyokimyası. Klinik Biyokimya, Medipol Univ.Yayınları 2015. 4)Henry's Klinical diagnosis and Managemen by laboratory methods. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Defines macro and micromolecules in cell and body fluids at an advanced level. | X | |||||
| 2 | Knows how to store and protect the material to be analyzed. | X | |||||
| 3 | Knows how to identify molecules found in cells and body fluids. | X | |||||
| 4 | Knows the principles of technologies to be used for routine and research purposes. | X | |||||
| 5 | Knows how to evaluate the results of the study, interprets and questions. | X | |||||
| 6 | Knows how to use field-specific tools and equipment | X | |||||
| 7 | Knows how to access and interpret field-specific resources and information | X | |||||
| 8 | Shares information with disciplines related to the field | X | |||||
| 9 | Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals. | X | |||||
| 10 | Solves a scientific and technical problem, knows where to get help. | X | |||||
| 11 | Takes responsibility in joint scientific studies, contributes and works in harmony. | X | |||||
| 12 | Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field. | X | |||||
| 13 | Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially. | X | |||||
| 14 | Can take part in management activities, evaluate the results obtained to improve quality | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 2 | 28 | |||
| Guided Problem Solving | 14 | 2 | 28 | |||
| Resolution of Homework Problems and Submission as a Report | 0 | 0 | 0 | |||
| Term Project | 4 | 5 | 20 | |||
| Presentation of Project / Seminar | 2 | 3 | 6 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 40 | 40 | |||
| General Exam | 1 | 45 | 45 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 167 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(167/30) | 6 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| ATHEROSCLEROSIS BIOCHEMISTRY | - | Fall Semester | 2+0 | 2 | 6 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Third Cycle (Doctorate Degree) |
| Course Type | Elective |
| Course Coordinator | |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assoc.Prof. Mukaddes ÇOLAKOĞULLARI |
| Assistant(s) | |
| Aim | To question the biochemical reactions during atherosclerosis process, to add comments for the development of new methods and drug discovery |
| Course Content | This course contains; Biochemistry of the atherosclerosis,Molecular changes in normal and damaged endothelium,Development of acute arterial damage and thrombosis,Thrombocyctes and atherosclerosis,Tissue factor and atherosclerosis,Tissue factor inhibitors,Plasminogen activators in atherosclerotic plaques,Plasminogen inhibitors and atherosclerosis,Coagulation factors and atherosclerosis,Relationship of cholesterol and atherosclerosis,Lipoprotein (a) and atherosclerosis,Cytokines and atherosclerosis,Animal models of atherosclerosis,Laboratory approach to thrombosis risk. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| Explain biochemistry of the atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Question molecular changes related to the endothelium | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Question thrombosis in the damaged endothelium | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.Explain the relationship between atherosclerosis and thrombosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Discuss the relation of thrombosis with atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Explain the changes of thrombosis adhesion during atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Explains the relationship between thrombosis secretion and atherosclerosis development | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Explains the relationship between thrombosis agregation and atherosclerosis development | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.Question the development of tissue factor both in normal and atherosclerotic plaques | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3-Explains the relationship of the tissue factor and the atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.Question the development of tissue factor both in normal and atherosclerotic plaques | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Question the relationship of lipoprotein (a) and thrombosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.6.Determine new method and drugs to inhibit tissue factor and thrombosis relationship | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Question the relationship of atherosclerosis and fibrinolytic system | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1.Explain plasminogen activator and inhibitors with thrombosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Question the relationship of lipoprotein (a) and thrombosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3.Discuss the relationship of homocysteine with thrombosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5-Question the relationship cholesterol and thrombosis development | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Explain the relationship of LDL-C and HDL-C with thrombosis development | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Discuss the mechanism of cholesterol-lowering drugs | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6-Determine signalling pathways related to atherosclerotic process | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.1.Explain cytokine related atherosclerosis process | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.2.Explain markers related to atherosclerosis development | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.3.Develops new methods for the early diagnosis of atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7-Evaluate animal models related to atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.1.Explain animal models resistant to atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.2.Explain the transgenic animal models related to atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.3.Explains the relationship of Apo E and HDL relationship in animal models | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.4.Explain the atherosclerotic changes in transgenic animal models | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.5.Determine new ideas about animals models related to atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1. Explains the biochemical mechanism of atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4. Determines creative ideas, medications and methods to prevent endothelial damage | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2. Explain the arterial damage in animal models | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3. Explains how regulation is achieved in circulating tissue factor and thrombus formation. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.5. Questions the relationship of the tissue factor inhibitor and the atherosclerosis | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4. Discover new method and drugs | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3. Determine drugs about cholesterol-related mechanisms | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Biochemistry of the atherosclerosis | 1, 2, 3, 4 |
| 2 | Molecular changes in normal and damaged endothelium | 1, 2, 3, 4 |
| 3 | Development of acute arterial damage and thrombosis | 1, 2, 3, 4 |
| 4 | Thrombocyctes and atherosclerosis | 1, 2, 3, 4 |
| 5 | Tissue factor and atherosclerosis | 1, 2, 3, 4 |
| 6 | Tissue factor inhibitors | 1, 2, 3, 4 |
| 7 | Plasminogen activators in atherosclerotic plaques | 1, 2, 3, 4 |
| 8 | Plasminogen inhibitors and atherosclerosis | 1, 2, 3, 4 |
| 9 | Coagulation factors and atherosclerosis | 1, 2, 3, 4 |
| 10 | Relationship of cholesterol and atherosclerosis | 1, 2, 3, 4 |
| 11 | Lipoprotein (a) and atherosclerosis | 1, 2, 3, 4 |
| 12 | Cytokines and atherosclerosis | 1, 2, 3, 4 |
| 13 | Animal models of atherosclerosis | 1, 2, 3, 4 |
| 14 | Laboratory approach to thrombosis risk | 1, 2, 3, 4 |
| Resources |
| 1)Williams Hematoloji (International Edition) 2)Wintrobe Hematoloji (International Edition) 3)Kartal N. Karademir B, Batırel S.Ateroskleroz Biyokimyası. Klinik Biyokimya, Medipol Univ.Yayınları 2015. 4)Henry's Klinical diagnosis and Managemen by laboratory methods. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Defines macro and micromolecules in cell and body fluids at an advanced level. | X | |||||
| 2 | Knows how to store and protect the material to be analyzed. | X | |||||
| 3 | Knows how to identify molecules found in cells and body fluids. | X | |||||
| 4 | Knows the principles of technologies to be used for routine and research purposes. | X | |||||
| 5 | Knows how to evaluate the results of the study, interprets and questions. | X | |||||
| 6 | Knows how to use field-specific tools and equipment | X | |||||
| 7 | Knows how to access and interpret field-specific resources and information | X | |||||
| 8 | Shares information with disciplines related to the field | X | |||||
| 9 | Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals. | X | |||||
| 10 | Solves a scientific and technical problem, knows where to get help. | X | |||||
| 11 | Takes responsibility in joint scientific studies, contributes and works in harmony. | X | |||||
| 12 | Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field. | X | |||||
| 13 | Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially. | X | |||||
| 14 | Can take part in management activities, evaluate the results obtained to improve quality | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |