Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assist.Prof. Gözde ÜLFER, Assoc.Prof. Sultan Sibel ERDEM, Assoc.Prof. Mukaddes ÇOLAKOĞULLARI
Assistant(s)
Aim
To understand the mechanism and progression of the cancer disease, to have advanced knowledge about the biochemical process of the cancer development and discuss the research about the cancer treatment
Course Content
This course contains; DNA damage and cancer,Biochemical mechanism of tumor markers,Cell proliferation and oncoproteins,Tumor-supressing genes,Adhesion molecules and their relationship with metastasis,Evaluation of tumor markers in clinic,Markers related to drug metabolism,Markers that are specific tumor drug response,DNA repair proteins,Mutations,The importance of mass spectrophotometry in cancer,Cancer and proteomics,Upcoming cancer research,Cancer biochemistry in system biology.
Dersin Öğrenme Kazanımları
Teaching Methods
Assessment Methods
At the end of this course, the students will be able to:
1.Question biochemical mechanisms about the cancer progression
10, 11, 16, 19, 6, 9
A, D, E
2.Learn the concepts of oncogene, tumor suppressing gene and mutation
10, 11, 16, 19, 6, 9
A, D, E
3.Question DNA mutations that affect cancer progression
10, 11, 16, 19, 6, 9
A, D, E
4.Discuss the difference in carbohydrate and lipid metabolism in normal and cancer cells
10, 11, 16, 19, 6, 9
A, D, E
5.Evaluate tumor markers of cancer cells and their application in laboratory
10, 11, 16, 19, 6, 9
A, D, E
6.Evaulate apoptosis, angiogenesis, and metastasis which are basic factors of cancer and question these concepts during cancer progress
10, 11, 16, 19, 6, 9
A, D, E
7.Explain types of the chemotherapeutic agents used for cancer treatment and their mechanism of action
10, 11, 16, 19, 6, 9
A, D, E
8.Explain the importance of the laboratory methods at cancer diagnosis, progression and treatment
A: Traditional Written Exam, D: Oral Exam, E: Homework
Course Outline
Order
Subjects
Preliminary Work
1
DNA damage and cancer
1, 2, 3, 4, 5
2
Biochemical mechanism of tumor markers
1, 2, 3, 4, 5
3
Cell proliferation and oncoproteins
1, 2, 3, 4, 5
4
Tumor-supressing genes
1, 2, 3, 4, 5
5
Adhesion molecules and their relationship with metastasis
1, 2, 3, 4, 5
6
Evaluation of tumor markers in clinic
1, 2, 3, 4, 5
7
Markers related to drug metabolism
1, 2, 3, 4, 5
8
Markers that are specific tumor drug response
1, 2, 3, 4, 5
9
DNA repair proteins
1, 2, 3, 4, 5
10
Mutations
1, 2, 3, 4, 5
11
The importance of mass spectrophotometry in cancer
1, 2, 3, 4, 5
12
Cancer and proteomics
1, 2, 3, 4, 5
13
Upcoming cancer research
1, 2, 3, 4, 5
14
Cancer biochemistry in system biology
1, 2, 3, 4, 5
Resources
1) Weinberg, R. The Biology of Cancer, Garland Science, 2007.
2) Weber G, Molecular Mechanisms of Cancer, 2007.
3) Mazurek, Sybille, Shoshan, Maria (Eds.) Tumour Cell Metabolism Pathways, Regulation and Biology, 2015.
4) Prof.Dr. Nesrin Emekli, Doç.Dr.Türkan Yiğitbaşı (Ed.). Klinik Biyokimya, Kanser Biyokimyası (Bölüm 34).
5) Lecture notes
Course Contribution to Program Qualifications
Course Contribution to Program Qualifications
No
Program Qualification
Contribution Level
1
2
3
4
5
1
Defines macro and micromolecules in cell and body fluids at an advanced level.
X
2
Knows how to store and protect the material to be analyzed.
X
3
Knows how to identify molecules found in cells and body fluids.
X
4
Knows the principles of technologies to be used for routine and research purposes.
X
5
Knows how to evaluate the results of the study, interprets and questions.
X
6
Knows how to use field-specific tools and equipment
X
7
Knows how to access and interpret field-specific resources and information
X
8
Shares information with disciplines related to the field
X
9
Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals.
X
10
Solves a scientific and technical problem, knows where to get help.
X
11
Takes responsibility in joint scientific studies, contributes and works in harmony.
X
12
Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field.
X
13
Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially.
X
14
Can take part in management activities, evaluate the results obtained to improve quality
Assessment Methods
Contribution Level
Absolute Evaluation
Rate of Midterm Exam to Success
50
Rate of Final Exam to Success
50
Total
100
ECTS / Workload Table
Activities
Number of
Duration(Hour)
Total Workload(Hour)
Course Hours
14
2
28
Guided Problem Solving
14
2
28
Resolution of Homework Problems and Submission as a Report
5
10
50
Term Project
2
10
20
Presentation of Project / Seminar
2
1
2
Quiz
0
0
0
Midterm Exam
1
20
20
General Exam
1
30
30
Performance Task, Maintenance Plan
0
0
0
Total Workload(Hour)
178
Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(178/30)
6
ECTS of the course: 30 hours of work is counted as 1 ECTS credit.
Detail Informations of the Course
Course Description
Course
Code
Semester
T+P (Hour)
Credit
ECTS
CANCER BIOCHEMISTRY II
-
Spring Semester
2+0
2
6
Course Program
Prerequisites Courses
Recommended Elective Courses
Language of Course
Turkish
Course Level
Third Cycle (Doctorate Degree)
Course Type
Elective
Course Coordinator
Assist.Prof. Çağrı ÇAKICI
Name of Lecturer(s)
Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assist.Prof. Gözde ÜLFER, Assoc.Prof. Sultan Sibel ERDEM, Assoc.Prof. Mukaddes ÇOLAKOĞULLARI
Assistant(s)
Aim
To understand the mechanism and progression of the cancer disease, to have advanced knowledge about the biochemical process of the cancer development and discuss the research about the cancer treatment
Course Content
This course contains; DNA damage and cancer,Biochemical mechanism of tumor markers,Cell proliferation and oncoproteins,Tumor-supressing genes,Adhesion molecules and their relationship with metastasis,Evaluation of tumor markers in clinic,Markers related to drug metabolism,Markers that are specific tumor drug response,DNA repair proteins,Mutations,The importance of mass spectrophotometry in cancer,Cancer and proteomics,Upcoming cancer research,Cancer biochemistry in system biology.
Dersin Öğrenme Kazanımları
Teaching Methods
Assessment Methods
At the end of this course, the students will be able to:
1.Question biochemical mechanisms about the cancer progression
10, 11, 16, 19, 6, 9
A, D, E
2.Learn the concepts of oncogene, tumor suppressing gene and mutation
10, 11, 16, 19, 6, 9
A, D, E
3.Question DNA mutations that affect cancer progression
10, 11, 16, 19, 6, 9
A, D, E
4.Discuss the difference in carbohydrate and lipid metabolism in normal and cancer cells
10, 11, 16, 19, 6, 9
A, D, E
5.Evaluate tumor markers of cancer cells and their application in laboratory
10, 11, 16, 19, 6, 9
A, D, E
6.Evaulate apoptosis, angiogenesis, and metastasis which are basic factors of cancer and question these concepts during cancer progress
10, 11, 16, 19, 6, 9
A, D, E
7.Explain types of the chemotherapeutic agents used for cancer treatment and their mechanism of action
10, 11, 16, 19, 6, 9
A, D, E
8.Explain the importance of the laboratory methods at cancer diagnosis, progression and treatment
A: Traditional Written Exam, D: Oral Exam, E: Homework
Course Outline
Order
Subjects
Preliminary Work
1
DNA damage and cancer
1, 2, 3, 4, 5
2
Biochemical mechanism of tumor markers
1, 2, 3, 4, 5
3
Cell proliferation and oncoproteins
1, 2, 3, 4, 5
4
Tumor-supressing genes
1, 2, 3, 4, 5
5
Adhesion molecules and their relationship with metastasis
1, 2, 3, 4, 5
6
Evaluation of tumor markers in clinic
1, 2, 3, 4, 5
7
Markers related to drug metabolism
1, 2, 3, 4, 5
8
Markers that are specific tumor drug response
1, 2, 3, 4, 5
9
DNA repair proteins
1, 2, 3, 4, 5
10
Mutations
1, 2, 3, 4, 5
11
The importance of mass spectrophotometry in cancer
1, 2, 3, 4, 5
12
Cancer and proteomics
1, 2, 3, 4, 5
13
Upcoming cancer research
1, 2, 3, 4, 5
14
Cancer biochemistry in system biology
1, 2, 3, 4, 5
Resources
1) Weinberg, R. The Biology of Cancer, Garland Science, 2007.
2) Weber G, Molecular Mechanisms of Cancer, 2007.
3) Mazurek, Sybille, Shoshan, Maria (Eds.) Tumour Cell Metabolism Pathways, Regulation and Biology, 2015.
4) Prof.Dr. Nesrin Emekli, Doç.Dr.Türkan Yiğitbaşı (Ed.). Klinik Biyokimya, Kanser Biyokimyası (Bölüm 34).
5) Lecture notes
Course Contribution to Program Qualifications
Course Contribution to Program Qualifications
No
Program Qualification
Contribution Level
1
2
3
4
5
1
Defines macro and micromolecules in cell and body fluids at an advanced level.
X
2
Knows how to store and protect the material to be analyzed.
X
3
Knows how to identify molecules found in cells and body fluids.
X
4
Knows the principles of technologies to be used for routine and research purposes.
X
5
Knows how to evaluate the results of the study, interprets and questions.
X
6
Knows how to use field-specific tools and equipment
X
7
Knows how to access and interpret field-specific resources and information
X
8
Shares information with disciplines related to the field
X
9
Combines theoretical and factual knowledge with critical thoughts, conducts independent studies, evaluates the results, compares them with the literature, and gets them accepted by authors and scientific journals.
X
10
Solves a scientific and technical problem, knows where to get help.
X
11
Takes responsibility in joint scientific studies, contributes and works in harmony.
X
12
Participates in meetings related to the field of biochemistry, presents papers, participates in discussions and congresses, publishes studies in reputable journals specific to the field.
X
13
Collects, interprets, applies, announces data related to the field of biochemistry, conducts social and cultural studies, and supervises these studies scientifically and socially.
X
14
Can take part in management activities, evaluate the results obtained to improve quality
