Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| HAEMOSTASIS BIOCHEMISTRY I | BYKY1123640 | Fall Semester | 2+2 | 3 | 6 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assist.Prof. Çağrı ÇAKICI, Assist.Prof. Derya CANSIZ |
| Assistant(s) | Prof.Dr.Nesrin Emekli, Assoc. Prof. Dr.Türkan Yiğitbaşı, Asso.Prof. Mukaddes Çolakoğlu , Ass. Prof .Dr.Sibel Erdem |
| Aim | Understand biochemical mechanism underlying bleeding and thrombosis, improves analytical knowledge about the hemostatic system |
| Course Content | This course contains; ,,,,,,,,,,,,,. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-Discuss the characteristics of the endothelial cell in which blood circulates. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Explains why endothelium is antithrombogenic. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Explains the relationship between subendotel and von Willebrand factor. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Discuss the molecules released from the endothelium. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Discuss the measurement of metabolic properties and functions of platelets. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Explains the adhesion, secretion and aggregation functions of platelets. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Discuss how platelet functions are measured. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Explains the activation and inactivation of platelets. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Describes the defects of platelet membrane proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3-Evaluates thrombus biochemically. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.In coronary heart diseases, cerebrovascular diseases and various organ diseases Questions the clot that occurs in emboli. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2.Analyzes atherosclerosis, which is one of the most deadly diseases today, in terms of thrombus. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3.Summarizes the relationship between vascular damage and thrombus. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4.Explains how to use knowledge about thrombosis in relevant laboratory tests. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Discuss the properties and measurement of clotting proteins in blood. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1.Understands contact activation factors and their measurement. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Explains the measurement and properties of vitamin K-dependent clotting factors. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5- Describes and compares inhibitors in the coagulation system. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Heparinin molekül yapısını çeşitlerini ve etkilerini açıklar. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Explains how to follow up the patient who is administered heparin in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Explains the mechanism by which oral anticoagulants can be effective. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4.Explains the mechanism of the inhibitory effect of protein C on clotting. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.5.Questions about other inhibitors that are effective in the coagulation system. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.Explains the mechanism of action of tissue factor and tissue factor pathway inhibitor. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.1.Can discuss the fibrinolytic system and tests related to the fibrinolytic system. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.2.Understands the molecular structure and effects of plasminogen and plasmin | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.4.Describes fibrin and fibrinogen breakdown products. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.5.Discuss laboratory methods of the fibrinolytic system. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7-Knows the use of devices and instruments in the field of hemostasis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8-Analyzes printed and electronic resources in the field of hemostasis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9-Takes responsibility in management activities and evaluates the results obtained within the framework of quality processes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4. Discusses the consequences of endothelial damage. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3. Explains and analyzes the properties of thrombin and its measurement in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4. Analyzes the importance of calcium in the coagulation cascade. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.3.. Questions plasminogen activators and inactivators. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | 1,2 | |
| 2 | 1,2 | |
| 3 | 1,2 | |
| 4 | 1,2 | |
| 5 | 1,2 | |
| 6 | 1,2 | |
| 7 | 1,2 | |
| 8 | 1,2 | |
| 9 | 1,2 | |
| 10 | 1,2 | |
| 11 | 1,2 | |
| 12 | 1,2 | |
| 13 | 1,2 | |
| 14 | 1,2 |
| Resources |
| 1) Biochemistry of Haemostatic system in Basic and Applied Biochemistry, Nesrin Emekli Nobel Tıp Kitapevleri 2) Williams Haematology. Beutler, Lichtman, Coller, Kipps ve Seligsohn |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Knows the biochemical macromolecular metabolism. Applies and advances the knowlegde. | X | |||||
| 2 | Knows the principles of routine and research oriented biochemical technologies. | X | |||||
| 3 | Practical Laboratory Applications (Sampling conditions of various body fluids and tissue samples in health and disease states, reasons of analytical errors, storage conditions of samples,working principles of technologies used in routine and research based studies, determinig reference values.) | X | |||||
| 4 | Knows basic biostatistics methods, applies to experimental study results and evaluates. | ||||||
| 5 | Knows how to use specific instruments in biochemistry | X | |||||
| 6 | Can access printeed and electronic literature and able to follow the advancements in biochemistry and related field. | X | |||||
| 7 | Can integrate and interpret the knowledge gained in biochemistry with knowledge obtained in other fields and can generate new information. | X | |||||
| 8 | Independantly applies his/her theoretical knowledge, critical thinking skills to the area of study, evaluates the results and writes a report. | X | |||||
| 9 | Defines a technical or scientific problem either with the helpof an advisor or independently, can come up with proposals and solve when needed. | X | |||||
| 10 | Take on responsibility in collborative studies, contributes and work in harmony. | X | |||||
| 11 | Follows national and international literature in Biochemistry, presents the work in seminars or publishes in journals. | X | |||||
| 12 | Can evaluate and teach biochemical data collection, interpretation, application and decleration recpecting cultural, scientific, social and ethical values. | X | |||||
| 13 | Take responsibility in managing, evaluate the results according to the context of quality processes. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 2 | 28 | |||
| Guided Problem Solving | 14 | 2 | 28 | |||
| Resolution of Homework Problems and Submission as a Report | 5 | 10 | 50 | |||
| Term Project | 2 | 4 | 8 | |||
| Presentation of Project / Seminar | 2 | 2 | 4 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 20 | 20 | |||
| General Exam | 1 | 40 | 40 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 178 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(178/30) | 6 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| HAEMOSTASIS BIOCHEMISTRY I | BYKY1123640 | Fall Semester | 2+2 | 3 | 6 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assist.Prof. Çağrı ÇAKICI, Assist.Prof. Derya CANSIZ |
| Assistant(s) | Prof.Dr.Nesrin Emekli, Assoc. Prof. Dr.Türkan Yiğitbaşı, Asso.Prof. Mukaddes Çolakoğlu , Ass. Prof .Dr.Sibel Erdem |
| Aim | Understand biochemical mechanism underlying bleeding and thrombosis, improves analytical knowledge about the hemostatic system |
| Course Content | This course contains; ,,,,,,,,,,,,,. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-Discuss the characteristics of the endothelial cell in which blood circulates. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Explains why endothelium is antithrombogenic. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Explains the relationship between subendotel and von Willebrand factor. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Discuss the molecules released from the endothelium. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Discuss the measurement of metabolic properties and functions of platelets. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Explains the adhesion, secretion and aggregation functions of platelets. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Discuss how platelet functions are measured. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Explains the activation and inactivation of platelets. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Describes the defects of platelet membrane proteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3-Evaluates thrombus biochemically. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.In coronary heart diseases, cerebrovascular diseases and various organ diseases Questions the clot that occurs in emboli. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2.Analyzes atherosclerosis, which is one of the most deadly diseases today, in terms of thrombus. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3.Summarizes the relationship between vascular damage and thrombus. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4.Explains how to use knowledge about thrombosis in relevant laboratory tests. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Discuss the properties and measurement of clotting proteins in blood. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1.Understands contact activation factors and their measurement. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Explains the measurement and properties of vitamin K-dependent clotting factors. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5- Describes and compares inhibitors in the coagulation system. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Heparinin molekül yapısını çeşitlerini ve etkilerini açıklar. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Explains how to follow up the patient who is administered heparin in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Explains the mechanism by which oral anticoagulants can be effective. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4.Explains the mechanism of the inhibitory effect of protein C on clotting. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.5.Questions about other inhibitors that are effective in the coagulation system. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.Explains the mechanism of action of tissue factor and tissue factor pathway inhibitor. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.1.Can discuss the fibrinolytic system and tests related to the fibrinolytic system. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.2.Understands the molecular structure and effects of plasminogen and plasmin | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.4.Describes fibrin and fibrinogen breakdown products. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.5.Discuss laboratory methods of the fibrinolytic system. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7-Knows the use of devices and instruments in the field of hemostasis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8-Analyzes printed and electronic resources in the field of hemostasis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9-Takes responsibility in management activities and evaluates the results obtained within the framework of quality processes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4. Discusses the consequences of endothelial damage. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3. Explains and analyzes the properties of thrombin and its measurement in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4. Analyzes the importance of calcium in the coagulation cascade. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.3.. Questions plasminogen activators and inactivators. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | 1,2 | |
| 2 | 1,2 | |
| 3 | 1,2 | |
| 4 | 1,2 | |
| 5 | 1,2 | |
| 6 | 1,2 | |
| 7 | 1,2 | |
| 8 | 1,2 | |
| 9 | 1,2 | |
| 10 | 1,2 | |
| 11 | 1,2 | |
| 12 | 1,2 | |
| 13 | 1,2 | |
| 14 | 1,2 |
| Resources |
| 1) Biochemistry of Haemostatic system in Basic and Applied Biochemistry, Nesrin Emekli Nobel Tıp Kitapevleri 2) Williams Haematology. Beutler, Lichtman, Coller, Kipps ve Seligsohn |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Knows the biochemical macromolecular metabolism. Applies and advances the knowlegde. | X | |||||
| 2 | Knows the principles of routine and research oriented biochemical technologies. | X | |||||
| 3 | Practical Laboratory Applications (Sampling conditions of various body fluids and tissue samples in health and disease states, reasons of analytical errors, storage conditions of samples,working principles of technologies used in routine and research based studies, determinig reference values.) | X | |||||
| 4 | Knows basic biostatistics methods, applies to experimental study results and evaluates. | ||||||
| 5 | Knows how to use specific instruments in biochemistry | X | |||||
| 6 | Can access printeed and electronic literature and able to follow the advancements in biochemistry and related field. | X | |||||
| 7 | Can integrate and interpret the knowledge gained in biochemistry with knowledge obtained in other fields and can generate new information. | X | |||||
| 8 | Independantly applies his/her theoretical knowledge, critical thinking skills to the area of study, evaluates the results and writes a report. | X | |||||
| 9 | Defines a technical or scientific problem either with the helpof an advisor or independently, can come up with proposals and solve when needed. | X | |||||
| 10 | Take on responsibility in collborative studies, contributes and work in harmony. | X | |||||
| 11 | Follows national and international literature in Biochemistry, presents the work in seminars or publishes in journals. | X | |||||
| 12 | Can evaluate and teach biochemical data collection, interpretation, application and decleration recpecting cultural, scientific, social and ethical values. | X | |||||
| 13 | Take responsibility in managing, evaluate the results according to the context of quality processes. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |