Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| CANCER BIOCHEMISTRY I | BYKY1123680 | Fall Semester | 2+0 | 2 | 7 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | Assist.Prof. Çağrı ÇAKICI |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assist.Prof. Gözde ÜLFER, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Çağrı ÇAKICI, Assist.Prof. Derya CANSIZ |
| Assistant(s) | Prof.Dr.Nesrin Emekli, Assoc. Prof. Dr.Türkan Yiğitbaşı, Ass. Prof .Dr.Sibel Erdem |
| Aim | Understand the biochemical processes in cancer disease |
| Course Content | This course contains; Cancer diagnosis and therapeutics in biochemical aspect,Tumor biomarkers,α- fetoprotein,Growth factors in cancer,Growth factor receptors,Serum and urine markers in prostate cancer,Breast cancer markers,Markers related to multiple myelomas,Gastrointestinal system tumor markers,Tumor markers of lenfoma,Gynecological tumor markers,Tumor markers of leukemias,Thyroid and parathyroid cancer tumor markers,Tumor cells in circulation. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-Evaluates the view of cancer from a biochemical perspective. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Defines oncoproteins that determine cell proliferation. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Defines tumor suppressor and differentiation markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Compares adhesion molecules and metastasis markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4.Defines other tumor markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Discuss the changes in growth factors and receptors during tumorigenesis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Explains transforming growth factors and their receptors. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Defines the growth factor and its receptor derived from platelets. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Define fibroblast growth factor and its receptor. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Define epidermal growth factor and its receptor. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.5.Define hepatocyte growth factor and its receptor. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3-Can discuss frequently used tumor markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.Explains α-fetaprotein as a tumor marker. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2.Bir tümör belirteci olarak kanser antijenini açıklar. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4.Defines chorionic gonadropin as a tumor marker. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.5.Define prostate specific antigen as a tumor marker. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Explains the methods used in tumor antigen measurements. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Explains high performance liquid chromatography used in tumor antigen measurement. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3.Explains Immunohistochemical methods used in tumor antigen measurement. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4.Explains the enzyme methods used in tumor antigen measurement. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5-Can discuss circulating tumor markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Defines prostate and breast cancer markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Explain the markers of multiple myeloma. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Defines gastrointestinal system tumor markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4.Defines tumor markers in leukemia and lymphomas. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.6.Explains tumor markers in thyroid and parathyroid cancers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3. Identifies carcinoembryonic antigen as a tumor marker. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1. Explains the immunoassay method used in tumor antigen measurement. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.5. Identifies gynecological tumor markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Cancer diagnosis and therapeutics in biochemical aspect | 1, 2, 3 |
| 2 | Tumor biomarkers | 1, 2, 3 |
| 3 | α- fetoprotein | 1, 2, 3 |
| 4 | Growth factors in cancer | 1, 2, 3 |
| 5 | Growth factor receptors | 1, 2, 3 |
| 6 | Serum and urine markers in prostate cancer | 1, 2, 3 |
| 7 | Breast cancer markers | 1, 2, 3 |
| 8 | Markers related to multiple myelomas | 1, 2, 3 |
| 9 | Gastrointestinal system tumor markers | 1, 2, 3 |
| 10 | Tumor markers of lenfoma | 1, 2, 3 |
| 11 | Gynecological tumor markers | 1, 2, 3 |
| 12 | Tumor markers of leukemias | 1, 2, 3 |
| 13 | Thyroid and parathyroid cancer tumor markers | 1, 2, 3 |
| 14 | Tumor cells in circulation | 1, 2, 3 |
| Resources |
| 1) Biyokimya, Figen Gürdöl ve Evin Ademmoğlu 2) Henry's Clinical diagnosis and management by laboratory methods McPherson-Pincus, Elsevier 3) Literature based on cancer research |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Knows the biochemical macromolecular metabolism. Applies and advances the knowlegde. | X | |||||
| 2 | Knows the principles of routine and research oriented biochemical technologies. | ||||||
| 3 | Practical Laboratory Applications (Sampling conditions of various body fluids and tissue samples in health and disease states, reasons of analytical errors, storage conditions of samples,working principles of technologies used in routine and research based studies, determinig reference values.) | ||||||
| 4 | Knows basic biostatistics methods, applies to experimental study results and evaluates. | ||||||
| 5 | Knows how to use specific instruments in biochemistry | ||||||
| 6 | Can access printeed and electronic literature and able to follow the advancements in biochemistry and related field. | ||||||
| 7 | Can integrate and interpret the knowledge gained in biochemistry with knowledge obtained in other fields and can generate new information. | X | |||||
| 8 | Independantly applies his/her theoretical knowledge, critical thinking skills to the area of study, evaluates the results and writes a report. | ||||||
| 9 | Defines a technical or scientific problem either with the helpof an advisor or independently, can come up with proposals and solve when needed. | ||||||
| 10 | Take on responsibility in collborative studies, contributes and work in harmony. | ||||||
| 11 | Follows national and international literature in Biochemistry, presents the work in seminars or publishes in journals. | X | |||||
| 12 | Can evaluate and teach biochemical data collection, interpretation, application and decleration recpecting cultural, scientific, social and ethical values. | ||||||
| 13 | Take responsibility in managing, evaluate the results according to the context of quality processes. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 2 | 28 | |||
| Guided Problem Solving | 14 | 2 | 28 | |||
| Resolution of Homework Problems and Submission as a Report | 5 | 10 | 50 | |||
| Term Project | 2 | 8 | 16 | |||
| Presentation of Project / Seminar | 2 | 4 | 8 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 25 | 25 | |||
| General Exam | 1 | 40 | 40 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 195 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(195/30) | 7 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| CANCER BIOCHEMISTRY I | BYKY1123680 | Fall Semester | 2+0 | 2 | 7 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | Assist.Prof. Çağrı ÇAKICI |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assist.Prof. Gözde ÜLFER, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Çağrı ÇAKICI, Assist.Prof. Derya CANSIZ |
| Assistant(s) | Prof.Dr.Nesrin Emekli, Assoc. Prof. Dr.Türkan Yiğitbaşı, Ass. Prof .Dr.Sibel Erdem |
| Aim | Understand the biochemical processes in cancer disease |
| Course Content | This course contains; Cancer diagnosis and therapeutics in biochemical aspect,Tumor biomarkers,α- fetoprotein,Growth factors in cancer,Growth factor receptors,Serum and urine markers in prostate cancer,Breast cancer markers,Markers related to multiple myelomas,Gastrointestinal system tumor markers,Tumor markers of lenfoma,Gynecological tumor markers,Tumor markers of leukemias,Thyroid and parathyroid cancer tumor markers,Tumor cells in circulation. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-Evaluates the view of cancer from a biochemical perspective. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Defines oncoproteins that determine cell proliferation. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Defines tumor suppressor and differentiation markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Compares adhesion molecules and metastasis markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4.Defines other tumor markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Discuss the changes in growth factors and receptors during tumorigenesis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Explains transforming growth factors and their receptors. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Defines the growth factor and its receptor derived from platelets. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Define fibroblast growth factor and its receptor. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Define epidermal growth factor and its receptor. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.5.Define hepatocyte growth factor and its receptor. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3-Can discuss frequently used tumor markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.Explains α-fetaprotein as a tumor marker. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2.Bir tümör belirteci olarak kanser antijenini açıklar. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4.Defines chorionic gonadropin as a tumor marker. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.5.Define prostate specific antigen as a tumor marker. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Explains the methods used in tumor antigen measurements. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Explains high performance liquid chromatography used in tumor antigen measurement. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3.Explains Immunohistochemical methods used in tumor antigen measurement. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4.Explains the enzyme methods used in tumor antigen measurement. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5-Can discuss circulating tumor markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Defines prostate and breast cancer markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Explain the markers of multiple myeloma. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Defines gastrointestinal system tumor markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4.Defines tumor markers in leukemia and lymphomas. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.6.Explains tumor markers in thyroid and parathyroid cancers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3. Identifies carcinoembryonic antigen as a tumor marker. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1. Explains the immunoassay method used in tumor antigen measurement. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.5. Identifies gynecological tumor markers. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Cancer diagnosis and therapeutics in biochemical aspect | 1, 2, 3 |
| 2 | Tumor biomarkers | 1, 2, 3 |
| 3 | α- fetoprotein | 1, 2, 3 |
| 4 | Growth factors in cancer | 1, 2, 3 |
| 5 | Growth factor receptors | 1, 2, 3 |
| 6 | Serum and urine markers in prostate cancer | 1, 2, 3 |
| 7 | Breast cancer markers | 1, 2, 3 |
| 8 | Markers related to multiple myelomas | 1, 2, 3 |
| 9 | Gastrointestinal system tumor markers | 1, 2, 3 |
| 10 | Tumor markers of lenfoma | 1, 2, 3 |
| 11 | Gynecological tumor markers | 1, 2, 3 |
| 12 | Tumor markers of leukemias | 1, 2, 3 |
| 13 | Thyroid and parathyroid cancer tumor markers | 1, 2, 3 |
| 14 | Tumor cells in circulation | 1, 2, 3 |
| Resources |
| 1) Biyokimya, Figen Gürdöl ve Evin Ademmoğlu 2) Henry's Clinical diagnosis and management by laboratory methods McPherson-Pincus, Elsevier 3) Literature based on cancer research |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Knows the biochemical macromolecular metabolism. Applies and advances the knowlegde. | X | |||||
| 2 | Knows the principles of routine and research oriented biochemical technologies. | ||||||
| 3 | Practical Laboratory Applications (Sampling conditions of various body fluids and tissue samples in health and disease states, reasons of analytical errors, storage conditions of samples,working principles of technologies used in routine and research based studies, determinig reference values.) | ||||||
| 4 | Knows basic biostatistics methods, applies to experimental study results and evaluates. | ||||||
| 5 | Knows how to use specific instruments in biochemistry | ||||||
| 6 | Can access printeed and electronic literature and able to follow the advancements in biochemistry and related field. | ||||||
| 7 | Can integrate and interpret the knowledge gained in biochemistry with knowledge obtained in other fields and can generate new information. | X | |||||
| 8 | Independantly applies his/her theoretical knowledge, critical thinking skills to the area of study, evaluates the results and writes a report. | ||||||
| 9 | Defines a technical or scientific problem either with the helpof an advisor or independently, can come up with proposals and solve when needed. | ||||||
| 10 | Take on responsibility in collborative studies, contributes and work in harmony. | ||||||
| 11 | Follows national and international literature in Biochemistry, presents the work in seminars or publishes in journals. | X | |||||
| 12 | Can evaluate and teach biochemical data collection, interpretation, application and decleration recpecting cultural, scientific, social and ethical values. | ||||||
| 13 | Take responsibility in managing, evaluate the results according to the context of quality processes. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |