Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| DIABETES BIOCHEMISTRY I | - | Fall Semester | 2+2 | 3 | 6 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | Assist.Prof. Çağrı ÇAKICI |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assoc.Prof. Mukaddes ÇOLAKOĞULLARI |
| Assistant(s) | Prof.Dr.Nesrin Emekli, Assoc. Prof. Dr.Türkan Yiğitbaşı, Ass. Prof .Dr.Sibel Erdem |
| Aim | Learning biochemistry of diabetes and improve analytical concepts |
| Course Content | This course contains; Diabetes and biochemical parameters,Diabetes types and molecular changes,Mechanisms of action of insulin synthesis,Insulin receptor structure and the mechanism of action,The molecular mechanisms of insulin resistance,Diabetes and non-enzymatic glycation,The biochemical mechanism of the relationship between diabetes, atherosclerosis,Diabetes, lipid metabolism,The role of genetics in diabetes,In animal studies, models of diabetes,The biochemical mechanism of the relationship between obesity and diabetes,The mechanism of the relationship between diabetes exercise,Biochemistry of diabetes and aging,Oral antidiabetics and the mechanism of action . |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-Compares the biochemical mechanism of diabetes with other mechanisms. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Analyzes the biochemical mechanism of type 1 diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Explains the biochemical mechanism of type 2 diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Explains the secondary causes of diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4.Explains gestational diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Discuss laboratory findings in hyperglycemia. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Discuss the sugar levels in blood and urine. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Compares the osmolality of serum and urine. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Explains ketone bodies in serum and urine. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Discuss blood and urine pH. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.5.Analyzes the electrolyte balance in the blood during diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3-Explains the regulation of blood glucose. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.Explains the ways of using glucose. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4.Explains the ways of using glucose. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4- Defines fat metabolism in diabetes and obesity. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1.Explains the relationship between fat metabolism and exercise. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Explains the relationship between energy metabolism and exercise. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3.Explains the importance of leptin in fat metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4.Relates the effects of other hormones on fat metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.5.Analyzes the relationship between diabetes and atherosclerosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5-Analyzes glucose and HbAic measurements. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Explains and applies the glucose oxidase method. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Explains and applies the hexokinase method. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Questions chemical methods. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Analyzes glycated protein measurements. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6-Develops analytical thoughts for the prognosis of diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7-Can access printed and electronic information sources and gain analysis skills to follow developments in biochemistry and related fields. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.6. Discusses the criteria of diabetes and prediabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.7. Questions microalbuminuria in diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2. Explains the ways of storing glucose. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3. Questions the sources of glucose in the blood. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.5. Describe experimental animal models of diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Diabetes and biochemical parameters | 1, 2, 3 |
| 2 | Diabetes types and molecular changes | 1, 2, 3 |
| 3 | Mechanisms of action of insulin synthesis | 1, 2, 3 |
| 4 | Insulin receptor structure and the mechanism of action | 1, 2, 3 |
| 5 | The molecular mechanisms of insulin resistance | 1, 2, 3 |
| 6 | Diabetes and non-enzymatic glycation | 1, 2, 3 |
| 7 | The biochemical mechanism of the relationship between diabetes, atherosclerosis | 1, 2, 3 |
| 8 | Diabetes, lipid metabolism | 1, 2, 3 |
| 9 | The role of genetics in diabetes | 1, 2, 3 |
| 10 | In animal studies, models of diabetes | 1, 2, 3 |
| 11 | The biochemical mechanism of the relationship between obesity and diabetes | 1, 2, 3 |
| 12 | The mechanism of the relationship between diabetes exercise | 1, 2, 3 |
| 13 | Biochemistry of diabetes and aging | 1, 2, 3 |
| 14 | Oral antidiabetics and the mechanism of action | 1, 2, 3 |
| Resources |
| 1) Prof. Dr. Nesrin Emekli ve Doç.Dr. Türkan Yiğitbaşı'nın ders kitaplar 2) Biyokimya Prof. Dr. Figen Gürdöl ve Evin Ademoğlu 3) Theory, Analysis Correlation Clinical Chemistry Ed. Lawrence A. Kaplan ve Amadeo Pesce |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Knows the biochemical macromolecular metabolism. Applies and advances the knowlegde. | X | |||||
| 2 | Knows the principles of routine and research oriented biochemical technologies. | X | |||||
| 3 | Practical Laboratory Applications (Sampling conditions of various body fluids and tissue samples in health and disease states, reasons of analytical errors, storage conditions of samples,working principles of technologies used in routine and research based studies, determinig reference values.) | X | |||||
| 4 | Knows basic biostatistics methods, applies to experimental study results and evaluates. | ||||||
| 5 | Knows how to use specific instruments in biochemistry | X | |||||
| 6 | Can access printeed and electronic literature and able to follow the advancements in biochemistry and related field. | X | |||||
| 7 | Can integrate and interpret the knowledge gained in biochemistry with knowledge obtained in other fields and can generate new information. | X | |||||
| 8 | Independantly applies his/her theoretical knowledge, critical thinking skills to the area of study, evaluates the results and writes a report. | X | |||||
| 9 | Defines a technical or scientific problem either with the helpof an advisor or independently, can come up with proposals and solve when needed. | X | |||||
| 10 | Take on responsibility in collborative studies, contributes and work in harmony. | X | |||||
| 11 | Follows national and international literature in Biochemistry, presents the work in seminars or publishes in journals. | X | |||||
| 12 | Can evaluate and teach biochemical data collection, interpretation, application and decleration recpecting cultural, scientific, social and ethical values. | X | |||||
| 13 | Take responsibility in managing, evaluate the results according to the context of quality processes. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 2 | 28 | |||
| Guided Problem Solving | 14 | 2 | 28 | |||
| Resolution of Homework Problems and Submission as a Report | 5 | 8 | 40 | |||
| Term Project | 2 | 8 | 16 | |||
| Presentation of Project / Seminar | 2 | 2 | 4 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 20 | 20 | |||
| General Exam | 1 | 30 | 30 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 166 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(166/30) | 6 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| DIABETES BIOCHEMISTRY I | - | Fall Semester | 2+2 | 3 | 6 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | Assist.Prof. Çağrı ÇAKICI |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Türkan YİĞİTBAŞI, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Gözde ÜLFER, Assoc.Prof. Mukaddes ÇOLAKOĞULLARI |
| Assistant(s) | Prof.Dr.Nesrin Emekli, Assoc. Prof. Dr.Türkan Yiğitbaşı, Ass. Prof .Dr.Sibel Erdem |
| Aim | Learning biochemistry of diabetes and improve analytical concepts |
| Course Content | This course contains; Diabetes and biochemical parameters,Diabetes types and molecular changes,Mechanisms of action of insulin synthesis,Insulin receptor structure and the mechanism of action,The molecular mechanisms of insulin resistance,Diabetes and non-enzymatic glycation,The biochemical mechanism of the relationship between diabetes, atherosclerosis,Diabetes, lipid metabolism,The role of genetics in diabetes,In animal studies, models of diabetes,The biochemical mechanism of the relationship between obesity and diabetes,The mechanism of the relationship between diabetes exercise,Biochemistry of diabetes and aging,Oral antidiabetics and the mechanism of action . |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-Compares the biochemical mechanism of diabetes with other mechanisms. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Analyzes the biochemical mechanism of type 1 diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Explains the biochemical mechanism of type 2 diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Explains the secondary causes of diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4.Explains gestational diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Discuss laboratory findings in hyperglycemia. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Discuss the sugar levels in blood and urine. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Compares the osmolality of serum and urine. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Explains ketone bodies in serum and urine. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Discuss blood and urine pH. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.5.Analyzes the electrolyte balance in the blood during diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3-Explains the regulation of blood glucose. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.Explains the ways of using glucose. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4.Explains the ways of using glucose. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4- Defines fat metabolism in diabetes and obesity. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1.Explains the relationship between fat metabolism and exercise. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Explains the relationship between energy metabolism and exercise. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3.Explains the importance of leptin in fat metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.4.Relates the effects of other hormones on fat metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.5.Analyzes the relationship between diabetes and atherosclerosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5-Analyzes glucose and HbAic measurements. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Explains and applies the glucose oxidase method. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Explains and applies the hexokinase method. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Questions chemical methods. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Analyzes glycated protein measurements. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6-Develops analytical thoughts for the prognosis of diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7-Can access printed and electronic information sources and gain analysis skills to follow developments in biochemistry and related fields. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.6. Discusses the criteria of diabetes and prediabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.7. Questions microalbuminuria in diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2. Explains the ways of storing glucose. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3. Questions the sources of glucose in the blood. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.5. Describe experimental animal models of diabetes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Diabetes and biochemical parameters | 1, 2, 3 |
| 2 | Diabetes types and molecular changes | 1, 2, 3 |
| 3 | Mechanisms of action of insulin synthesis | 1, 2, 3 |
| 4 | Insulin receptor structure and the mechanism of action | 1, 2, 3 |
| 5 | The molecular mechanisms of insulin resistance | 1, 2, 3 |
| 6 | Diabetes and non-enzymatic glycation | 1, 2, 3 |
| 7 | The biochemical mechanism of the relationship between diabetes, atherosclerosis | 1, 2, 3 |
| 8 | Diabetes, lipid metabolism | 1, 2, 3 |
| 9 | The role of genetics in diabetes | 1, 2, 3 |
| 10 | In animal studies, models of diabetes | 1, 2, 3 |
| 11 | The biochemical mechanism of the relationship between obesity and diabetes | 1, 2, 3 |
| 12 | The mechanism of the relationship between diabetes exercise | 1, 2, 3 |
| 13 | Biochemistry of diabetes and aging | 1, 2, 3 |
| 14 | Oral antidiabetics and the mechanism of action | 1, 2, 3 |
| Resources |
| 1) Prof. Dr. Nesrin Emekli ve Doç.Dr. Türkan Yiğitbaşı'nın ders kitaplar 2) Biyokimya Prof. Dr. Figen Gürdöl ve Evin Ademoğlu 3) Theory, Analysis Correlation Clinical Chemistry Ed. Lawrence A. Kaplan ve Amadeo Pesce |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Knows the biochemical macromolecular metabolism. Applies and advances the knowlegde. | X | |||||
| 2 | Knows the principles of routine and research oriented biochemical technologies. | X | |||||
| 3 | Practical Laboratory Applications (Sampling conditions of various body fluids and tissue samples in health and disease states, reasons of analytical errors, storage conditions of samples,working principles of technologies used in routine and research based studies, determinig reference values.) | X | |||||
| 4 | Knows basic biostatistics methods, applies to experimental study results and evaluates. | ||||||
| 5 | Knows how to use specific instruments in biochemistry | X | |||||
| 6 | Can access printeed and electronic literature and able to follow the advancements in biochemistry and related field. | X | |||||
| 7 | Can integrate and interpret the knowledge gained in biochemistry with knowledge obtained in other fields and can generate new information. | X | |||||
| 8 | Independantly applies his/her theoretical knowledge, critical thinking skills to the area of study, evaluates the results and writes a report. | X | |||||
| 9 | Defines a technical or scientific problem either with the helpof an advisor or independently, can come up with proposals and solve when needed. | X | |||||
| 10 | Take on responsibility in collborative studies, contributes and work in harmony. | X | |||||
| 11 | Follows national and international literature in Biochemistry, presents the work in seminars or publishes in journals. | X | |||||
| 12 | Can evaluate and teach biochemical data collection, interpretation, application and decleration recpecting cultural, scientific, social and ethical values. | X | |||||
| 13 | Take responsibility in managing, evaluate the results according to the context of quality processes. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |