Geri
AKADEMİK

(Liste, ünvan ve isme göre alfabetik olarak sıralanmıştır.)

Kurum İçi Görevlendirme

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Adı Soyadı Prof.Dr. Lütfü HANOĞLU
E-Posta [email protected]
Detay Öz Geçmiş
Medya

Daha Önce Görev Yaptığı Yerler

Araştırma Alanları

Seçili Yayınları / Tüm Yayınları

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Adı Soyadı Prof.Dr. Gürkan ÖZTÜRK
E-Posta [email protected]
Detay Öz Geçmiş
Medya

Hacettepe Üniversitesi 1993 King's College London

Daha Önce Görev Yaptığı Yerler

Yüzüncü Yıl Üniversitesi

Araştırma Alanları

Nörodejeneratif ve nörorejeneratif süreçlerde etkin olan moleküler ve hücresel mekanizmaların anlaşılmasında hücre kültürü ve hayvan modelleriyle araştırmalar yapmaktadır. Bir başka uzmanlık alanı ileri mikroskopik görüntüleme ve manipülasyon teknikleridir.

Seçili Yayınları / Tüm Yayınları

Aydin, M.S., Yigit, E.N., Vatandaslar, E., Erdogan, E. & Ozturk, G. (2018) Transfer and Integration of Breast Milk Stem Cells to the Brain of Suckling Pups. Sci Rep, 8, 14289.
Aysit-Altuncu, N., Ulusoy, C., Ozturk, G. & Tuzun, E. (2018) Effect of LGI1 antibody-positive IgG on hippocampal neuron survival: a preliminary study. Neuroreport, 29, 932-938.
Bal, R., Ozturk, G., Etem, E.O., Him, A., Cengiz, N., Kuloglu, T., Tuzcu, M., Yildirim, C. & Tektemur, A. (2018) Modulation of Excitability of Stellate Neurons in the Ventral Cochlear Nucleus of Mice by ATP-Sensitive Potassium Channels. J Membr Biol, 251, 163-178.
Demircan, T., Ovezmyradov, G., Yildirim, B., Keskin, I., Ilhan, A.E., Fescioglu, E.C., Ozturk, G. & Yildirim, S. (2018) Experimentally induced metamorphosis in highly regenerative axolotl (ambystoma mexicanum) under constant diet restructures microbiota. Sci Rep, 8, 10974.
Kuter, N., Aysit-Altuncu, N., Ozturk, G. & Ozek, E. (2018) The Neuroprotective Effects of Hypothermia on Bilirubin-Induced Neurotoxicity in vitro. Neonatology, 113, 360-365.
Caglayan, B., Caglayan, A.B., Beker, M.C., Yalcin, E., Beker, M., Kelestemur, T., Sertel, E., Ozturk, G., Kilic, U., Sahin, F. & Kilic, E. (2017) Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice. Experimental neurology, 296, 23-31.
Demircan, T., Keskin, I., Dumlu, S.N., Ayturk, N., Avsaroglu, M.E., Akgun, E., Ozturk, G. & Baykal, A.T. (2017) Detailed tail proteomic analysis of axolotl (Ambystoma mexicanum) using an mRNA-seq reference database. Proteomics, 17.
Shahbazi, R., Ozcicek, I., Ozturk, G. & Ulubayram, K. (2017) Functionalized gold nanoparticles manifested as potent carriers for nucleolar targeting. Nanotechnology, 28, 025103.
Demircan, T., Ilhan, A.E., Ayturk, N., Yildirim, B., Ozturk, G. & Keskin, I. (2016) A histological atlas of the tissues and organs of neotenic and metamorphosed axolotl. Acta Histochem, 118, 746-759.
Kilic, E., Reitmeir, R., Kilic, U., Caglayan, A.B., Beker, M.C., Kelestemur, T., Ethemoglu, M.S., Ozturk, G. & Hermann, D.M. (2014) HMG-CoA Reductase Inhibition Promotes Neurological Recovery, Peri-Lesional Tissue Remodeling, and Contralesional Pyramidal Tract Plasticity after Focal Cerebral Ischemia. Front Cell Neurosci, 8, 422.
Bektas, S. & Ozturk, G. (2013) Enhancement of cultured adult motor neuron survival with cold pre-incubation. Neurosci Lett, 533, 23-27.
Ozturk, G., Cengiz, N., Erdogan, E., Him, A., Oguz, E.K., Yenidunya, E. & Aysit, N. (2013) Two distinct types of dying back axonal degeneration in vitro. Neuropathol Appl Neurobiol, 39, 362-376.
Cengiz, N., Ozturk, G., Erdogan, E., Him, A. & Oguz, E.K. (2012) Consequences of neurite transection in vitro. J Neurotrauma, 29, 2465-2474.
Demir, O., Aysit, N., Onder, Z., Turkel, N., Ozturk, G., Sharrocks, A.D. & Kurnaz, I.A. (2011) ETS-domain transcription factor Elk-1 mediates neuronal survival: SMN as a potential target. Biochimica et biophysica acta, 1812, 652-662.

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Adı Soyadı Prof.Dr. Hasan KÖRKAYA
E-Posta [email protected]
Detay Öz Geçmiş
Medya

Daha Önce Görev Yaptığı Yerler

Araştırma Alanları

Seçili Yayınları / Tüm Yayınları

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Adı Soyadı Prof.Dr. Yasemin YÜKSEL DURMAZ
E-Posta [email protected]
Detay Öz Geçmiş
Medya

Yıldız Teknik Üniversitesi 2003 İstanbul Teknik Üniversitesi

Daha Önce Görev Yaptığı Yerler

University of Michigan (2010-2014 Postdoc)

Araştırma Alanları

Gen Tasimak icin ideal vektorlerin gelistirilmesi, Kontrollu İlac Tasıma Sistemleri, Hedefli Kanser Tedavisi icin Akıllı Parcacıklar Gelistirilmesi, Ultrason Gorüntüleme ve Tedavi Ajanları, Karmasik makromolekullerin tasarlanmasi ve sentezi

Seçili Yayınları / Tüm Yayınları

1. The Effects of Ultrasound Frequency on Nanodroplet-Mediated Histotripsy, E Vlaisavljevich, O Aydin, KW Lin, YY Durmaz, B Fowlkes, MEH ElSayed, Z Xu, Ultrasound in Medicine and Biology, 2015, 41(8), 2135-2147.
2. Development of Nanodroplets for Histotripsy-Mediated Cell Ablation, Y. Y. Durmaz, E. Vlaisavljevich, Z. Xu, M.E.H ElSayed, Molecular Pharmaceutics, 2014, 11(10), 3685-3695.
3. Nanodroplet-Mediated Histotripsy for Image-guided Targeted Ultrasound Cell Ablation, E. Vlaisavljevich, Y. Y. Durmaz, A. Maxwell, M.E.H. ElSayed, Zhen Xu, Theranostics, 2013, 3(11), 802-815.
4. Synergistic Combination of Small Molecule Inhibitor and RNA interference Against Anti-apoptotic Bcl-2 Protein in Head and Neck Cancer Cells, Y-L. Lin, Y. Y. Durmaz, J. E. Nör, M. E. H. ElSayed, Molecular Pharmaceutics, 2013, 10, 2730-2738.
5. Development of Degradable, pH-Sensitive Star Vectors for Enhancing the Cytoplasmic Delivery of Nucleic Acids, Y. Y. Durmaz, Y-L. Lin, M. E. H. ElSayed, Advanced Functional Materials, 2013, 23(31), 3885-3895.
6. Targeting Hepatic Cancer Cells with PEGylated Dendrimers Displaying N-Acetylgalactosamine and SP94 Peptide Ligands, S. H. Medina, G. Tiruchinapally, M. V. Chevliakov,
Y. Y. Durmaz, R. N. Stender, W. D. Ensminger, D. S. Shewach, M. E. H. ElSayed, Advanced Healthcare Materials, 2013, 2(10), 1337-1350.
7. Enzyme-Activated Nanoconjugates for Tunable Release of Doxorubicin in Hepatic Cancer Cells, S. H. Medina, M. V. Chevliakov, G. Tiruchinapally, Y. Y. Durmaz, S. P. Kuruvilla, M. E.H. ElSayed, Biometerials, 2013, 36, 4655-4666.
8. A Novel Poly(p-phenylene) Containing Alternating Poly(perfluorooctylethyl acrylate-co-methyl methacrylate) and Polystyrene Grafts by Combination of Atom Transfer Radical Polymerization and Suzuki Coupling Processes, Y. Y. Durmaz, E. L. Sahkulubey, Y. Yagci, E. Martinelli, G. Galli, Journal of Polymer Science Part A: Polymer Chemistry 2012, 50(23), 4911-4919
9. New Photoinitiating Systems for Cationic Polymerization Acting at Near UV and Visible Range, B. Aydogan, Y. Y. Durmaz, M. U. Kahveci, M. Uygun, M. A. Tasdelen, Y. Yagci, Macromolar Symposia 2011, 308, 25-34.
10. Film Formation of Poly(methyl metacrylate) Latex with Pyrene Functional Poly(divinylbenzene) Microspheres Prepared by Click Chemistry, S. Ugur, O. Yargi, Y. Y. Durmaz, B. Karagoz, N. Bicak, Y. Yagci, O. Pekcan, Polymer Composites, 2011, 32(6), 869-881.
11. Modification of Poly(divinylbenzene) Microspheres by Hydrobromination-Click Chemistry Protocol and Their Protein Adsorption Properties, Y. Y. Durmaz, B. Karagoz, N. Bicak, D. Odaci, E. Yalcinkaya, S. Timur, Y. Yagci, Macromolecular Bioscience, 2011, 11, 141-150.
12. Perfectly Alternating Amphiphilic Poly(p-phenylene) Graft Copolymers by Combination of Controlled Radical Polymerization and Suzuki Coupling Processes, E. L. Sahkulubey, Y. Y. Durmaz, Y. Yagci Macromolecules 2010, 43, 2732–2738.
13. Surface Modification of Cured Epoxy Network by Click Chemistry, Y. Y. Durmaz, M. Sangermano, Y. Yagci, Journal of Polymer Science Part A: Polymer Chemistry 2010, 48, 2862–2868.
14. Peculiarities of ?- and ?-Relaxations in Polymers with Cyanobiphenyl Liquid Crystalline Side Chains of different Lengths, F. Salehli, S. Yildiz, H. Ozbek, E. Uykur, Y. H. Gursel, Y. Y. Durmaz, Polymer 2010, 51, 1450-1456.
15. Synthesis and Characterization of Telechelic Polymers by Combination of Atom Transfer Radical Polymerization and Click Chemistry Processes, S. S. Okcu, Y. Y. Durmaz, Y. Yagci, Designed Monomer& Polymer 2010, 13, 459-472.
16. Synthesis and Characterization of Polystyrene Possessing Triptycene Units in the Main Chain by Combination of ATRP and Click Chemistry Processes, S. Ates, Y. Y. Durmaz, L. Torun, Y. Yagci, Journal of Macromolecular Science Part A: Pure and Applied Chemistry 2010, 47(8), 809-815.
17. Photoinduced Decomposition of Dibenzoyldiethylgermane: A Photochemical Route to Polygermanes, Y. Y. Durmaz, M. Kukut, N. Monszner, Y. Yagci, Macromolecules, 2009, 42, 2899-2902.
18. Graft Copolymers by the Combination of ATRP and Photochemical Acylation Process by Using Benzodioxinones, Y. Y. Durmaz, V. Kumbaraci, A. L. Demirel, N. Talinli, Y. Yagci, Macromolecules 2009, 42, 7343-3749.
19. Sequential Photodecomposition of Bisacylgermane Type Photoinitiator: Synthesis of Block Copolymers by Combination of Free Radical Promoted Cationic and Free Radical Polymerization Mechanisms, Y. Y. Durmaz, M. Kukut, N. Monszner, Y. Yagci, Journal of Polymer Science Part A: Polymer Chemistry 2009, 47, 4793–4799.
20. Functionalization of Poly(divinylbenzene) Microspheres via Click Chemistry Proceeses, B. Karagoz, Y. Y. Durmaz, B. N. Gacal, N. Bicak, Y. Yagci, Designed Monomer.& Polymer, 2009, 12, 511–522.
21. Dielectric Relaxation in a Thermotropic Side Chain Liquid Crystalline Polymer with Nematic Reentrant Phase F. Salehli, S. Yıldız, H. Ozbek, Y. H. Gursel, Y Y. Durmaz, Jornal of Physics: Condens. Matter, 2008, 20, 35106.
22. A New Photoiniferter/RAFT Agent for Ambient Temperature Rapid and Well-Controlled Radical Polymerization, M. A. Tasdelen, Y. Y. Durmaz, B. Karagoz, N. Bicak, Yusuf Yagci, Journal of Polymer Science Part A: Polymer Chemistry 2008, 46, 3387-3395.
23. Diethoxy-azobis(pyridinium) Salt as Photoinitiator for Cationic Polymerization: Towards Wavelength Tunability by Cis-Trans Isomerization, Y. Y. Durmaz, O. Zaim, Y. Yagci, Macrolomol. Rapid Communication 2008, 29, 892-896.
24. Synthesis, Characterization and Thermally Activated Curing of Azobenzene Containing Benzoxazines, B. Kiskan, F. Dogan, Y. Y. Durmaz, Y. Yagci, Designed Monomer& Polymer 2008, 11, 473–482.
25. Synthesis of Block Copolymers by Combination of ATRP and Photoiniferter Processes, Y.Y. Durmaz, B. Karagoz, N. Bicak, Y. Yagci, Polymer International 2008, 57, 1182–1187.
26. Visible Light Initiated Free Radical Promoted Cationic Polymerization by Using Acylgermane Based Photoinitiator in the Presence of Onium Salts, Y. Y. Durmaz, N. Moszner, Y. Yagci, Macromolecules 2008, 41, 6714-6718.
27. Use of Atom Transfer Radical Coupling Reactions for the Synthesis of Various Macromolecular Structure, Y. Y. Durmaz, B. Aydogan, I. Cianga, Y. Yagci, Polymer Preprints 2008, 49(2), 382-383.
28. N-alkoxy Pyridinium Ion Terminated Polystyrene: A Facile Route to Photoinduced Block Copolymerization, Y. Y. Durmaz, G. Yılmaz Y. Yagci, Journal of Polymer Science Part A: Polymer Chemistry 2007, 45 (3), 423-428.
29. Phenacyl Onium Salt Photoinitiators: Synthesis, Photolysis and Applications, Y. Yagci, Y. Y. Durmaz, B. Aydogan, Chemical Record 2007, 7, 78-90.
30. Polymers with Side Chain N-Alkoxy Pyridinium Ions as Precursors for Photoinduced Grafting and Modification Processes Y. Y. Durmaz, G. Yilmaz, Y. Yagci, Macromolecular Chemistry Physics 2007, 208, 1737-1743.
31. Studies on the Preparation of Telechelic Polymer by Atom Transfer Radical Polymerization and Cross Coupling Processes, Y. Y. Durmaz, I. Cianga, Y. Yagci, e-polymer 2006, 50.

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Adı Soyadı Doç.Dr. Mustafa GÜZEL
E-Posta [email protected]
Detay Öz Geçmiş
Medya

Hacettepe Üniversitesi 1987 Clemson Üniversitesi Mühendislik ve Doğal Bilimler Fakültesi Medisinal Kimya Anabilim Dalı

Daha Önce Görev Yaptığı Yerler

MEB (Kimya Öğretmenliği, 1988-1993, İzmir Yüksek Teknoloji Enstitüsü (Araştırma Görevlisi (1993-2000), Clemson Üniversitesi (Öğretim Görevlisi 1997-1998), Northeastern Üniversitesi (Misafir Araştırma Görevlisi ve Organik Kimya Lab. Koordinatörü, 1998-2000), ArQule Inc. (Senyör. Sentetik Organik Kimyacı, 2000), TransTech Pharma Inc. (Proje sorumlusu, uzman bilim insanı, medisinal kimya lab. direktörü, 2001-2014).

Araştırma Alanları

• Yenilikçi ilaç Ar-Ge çalışmaları, ilaç keşif ve geliştirme özellikle kanser, kinaz inhibitörleri, Tip-2 şeker hastalığının tedavisi için G Proteinle Çiftleşmiş Reseptörlerinin incelenmesi, obezlik, merkezi sinir sistemi hastalıkları (Alzheimer ve Parkinson gibi), römatoit artiritis gibi inflammasyonla ilgili ilaç geliştirilmesi. • Yeni ilaç moleküllerini geliştirmek üzere simetrik veya asimetrik moleküllerin dizayni ve senteziyle ilgili Ar-Ge çalişmaları. Doğal bileşiklerin aktif maddelerinin izolasyon, sentezleme metodları ve teknikleri. • Katalitik asimetrik indüksiyon reaksiyonlarının mekanizmalarının incelenmesi ve bunlardan çıkarak biyoljik sistemlerde aktif olabilecek ilaçlarin geliştirilip sentezleme yöntemleri.

Seçili Yayınları / Tüm Yayınları

1. "Gender Satisfaction among Type 2 Diabetes Patients: A Comparison between Intensive Diets, Lifestyle Intervention with Medication Controlled Management"; Abdulbari Bener, Abdulla O. A. A. Al-Hamaq, Funda Çatan, Kaleem U. Rajput and Mustafa Guzel; British Journal of Medicine & Medical Research, volume: 18, number: 7, page:1-13, 2016. DOI: 10.9734/BJMMR/2016/29418.
2. "Medisinal Kimyanın Yeni İlaç Keşif ve Geliştirmedeki Rolü ve Önemi:The Role and Importance of Medicinal Chemistry in Novel Drug Discovery and Development"; Mustafa Güzel, ve Sezgin Kiren; Turkish Clinics, Turkiye Klinikleri J Pharm Sci 2016;5(1):36-45, 2016. DOI: 10.5336/pharmsci.2015-48211.
3. "Synthesis of Substituted Pyridines from 1,2-Nucleophilic Addition Products of Functionalized N-Acyl-2,3-dihydropyridones"; Mustafa Guzel, Joshua Watts, Matthew McGilvary, Marcus Wright, and Sezgin Kiren; Tetrahedron Letters, volume: 56, number: 38, (2015), p:5872. doi:10.1016/j.tetlet.2015.07.045.
4. “Estimation of Octanol-Water Partition Coefficient Using Cationic Gemini Surfactants by Micellar Electrokinetic Chromatography’; Mustafa Guzel, Cevdet Akbay, Yatzka Hoyos , David H. Ahlstrom; Journal of Chromatography and Separation Techniques, volume: 6, number: 4, (2015), p-. doi:10.4172/2157- 7064.1000275.
5. "Induction of Heme Oxygenase I (HMOX1) by HPP-4382: A novel modulator of Bach-1 activity”; Otis Attucks, Kimberly Jasmer, Mark Hannink, Jareer Kassis, Zhenping Zhong, Suparna Gupta, Sam Victory, Mustafa Guzel, Dharma Polisetti, Robert Andrews, Adnan Mjalli, and Matthew Kostura; PLoSOne, 9, 7, (2014), p:1-12, e101044.
6. "Substituted Pyran Derivatives Useful as Antitumor Agents"; Mustafa Guzel, Devi Reddy, Rongyuan Xie, Dharma R. Polisetti, Stephen Davis, Soumya Sahoo, Hassan El Abdelloui, and Adnan M. M. Mjalli; High Point Pharmaceuticals Inc., High Point, NC, Patent #US 61/892,053, 2013.
7. "Substituted Fused Oxazoline Derivatives Useful as Antitumor Agents"; Mustafa Guzel, Devi Reddy, Rongyuan Xie, Dharma R. Polisetti, Soumya Sahoo, Stephen Davis, Mohan Rao, Kalpathy Santhosh, and Adnan M. M. Mjalli; High Point Pharmaceuticals Inc., High Point, NC, Patent #US 61/892,018, 2013.
8. "Characterization and application of molecular binary mixed molecular micelles of sodium10-undecenyl sulfate and sodium N-undecenyl leucinate as pseudostationary phases in micellar electrokinetic chromatography"; Cevdet Akbay, Hamid H. Ahmed, Hakan Arslan, Brittany Graham, and Mustafa Guzel; Talanta, 99, (2012), 441-449.
9. " Study of chemical selectivity of binary mixed micelles of sodium 10-undecenyl sulfate and sodium N-undecenyl leucinate using linear solvation energy reletionships model"; Hamid H. Ahmed, David M. Ahlstrom, Hakan Arslan, Mustafa Guzel, and Cevdet Akbay; Journal of Chromatography A, 1236, (2012), 207-214.
10. “Novel Anticancer agents for hexokinase inhibition-Substituted cyclic-3-indole derivatives”; Mustafa Guzel, Rongyuan Xie, Dharma R. Polisetti, Robert C. Andrews, Adnan M. M. Mjalli, and Stephen Davis; High Point Pharmaceuticals Inc., High Point, NC, Application No: HPP 3018.001 US; patent manuscript submitted, 2013.
11. “Substituted Benzimidazole Derivatives and Methods of Use to Treat Oxidative Stress”; Mustafa Guzel, Sam Victory, Dharma R. Polisetti, Mathew Kostura, Adnan M. M. Mjalli, Otis Attucks, and Jareer Kassis; High Point Pharmaceuticals Inc., High Point, NC, Application No: HPP 3007.000 US; patent manuscript submitted, 2012.
12. “Substituted Pyridine derivatives, Pharmaceutical Compositions, and Methods of Use to Treat Oxidative Stress”; Mustafa Guzel, Sam Victory, Bapu Gaddam, Dharma R. Polisetti, Mathew Kostura and Adnan M. M. Mjalli; High Point Pharmaceuticals Inc., High Point, NC, Patent # WO 2011/022216, (02, 24, 2011).
13. “Oxadiazoanthracene Compounds, for Treatments of Diabetes”; Scott T. Yokum, Mustafa Guzel, Kalpathy C. Santhosh, Dharma R. Polisetti, Daniel P. Christen, Adnan M. Mjalli, and Stephen T. Davis; TransTech Pharma Inc., High Point, NC, , Patent # US 2011/7906507 (03, 15, 2011).
14. “In Silico Ligand-Receptor Docking of Potentially Selective Butyrylcholinesterase Inhibitors Structurally Related to the Marine Natural Product Debromoflustramine B”; Miguel O. Mitchell, Robert W. Figliozzi and Mustafa Guzel; Medicinal Chemistry, Volume 6, Number 3, 2010, Pp. 141-143.
15. “Substituted Pyridine derivatives, Pharmaceutical Compositions, and Methods of Use to Treat Oxidative Stress”; Mustafa Guzel, Sam Victory, Bapu Gaddam, Dharma R. Polisetti, Mathew Kostura and Adnan M. M. Mjalli; High Point Pharmaceuticals Inc., High Point, NC, Patent # US 2010/044508, (05, 08, 2010).
16. “Mandelic Acid Derivatives and Preparation Thereof”; Mustafa Guzel, Scott T. Yokum, and Dharma R. Polisetti; TransTech Pharma Inc., High Point, NC, Patent # US 2010/0036150, (02,11, 2010).
17. “Oxadiazoanthracene Compounds, Compositions of Oxadiazoanthracene Compounds and Methods of Treatment Using the Same”; Scott T. Yokum, Mustafa Guzel, Kalpathy C. Santhosh, Dharma R. Polisetti, Daniel P. Christen, Adnan M. Mjalli, and Stephen T. Davis; TransTech Pharma Inc., High Point, NC, , Patent # US 2010/0324033 (12, 23, 2010).
18. “Substituted Azoanthracene Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof”; Mustafa Guzel, Scott T. Yokum, Kalpathy C. Santhosh, Dharma R. Polisetti, Chris Behme, Adnan M. Mjalli, and Stephen T. Davis”; TransTech Pharma Inc., High Point, NC, Patent # WO 2010/4824 (07, 10, 2010).
19. “Tricyclic Compounds as Modulators of TNF-? Synthesis”; Mustafa Guzel, Mathew Kostura, Adnan M. Mjalli, Bapu Gaddam, and Dharma R. Polisetti; TransTech Pharma Inc., High Point, NC, Patent # US 2010/0190808 (07, 29, 2010).
20. “Oxadiazoanthracene Compounds, for Treatments of Diabetes”; Scott T. Yokum, Mustafa Guzel, Kalpathy C. Santhosh, Dharma R. Polisetti, Daniel P. Christen, Adnan M. Mjalli, and Stephen T. Davis; TransTech Pharma Inc., High Point, NC, , Patent # WO 2009/111700 (11, 09, 2009).
21. “Aryl Carbonyl Derivatives as Therapeutic Agents-Part-II”; Kalpaty C. Santhosh, Mustafa Guzel, Dharma R. Polisetti, Adnan M. Mjalli, and Robert C. Andrews; TransTech Pharma Inc., High Point, NC, Patent # US 2009/7541373 (06, 02, 2009).
22. “Tricyclic Compounds as Modulators of TNF-? Synthesis as PDE4 Inhibitors”; Mustafa Guzel, Mathew Kostura, Adnan M. Mjalli, Bapu Gaddam, and Dharma R. Polisetti; TransTech Pharma Inc., High Point, NC, Patent # WO 2009/094528, (07, 30, 2009).
23. “Aryl, and Hetoroaryl Compounds, Compositions, and Methods of Use”; Mustafa Guzel, Murty Arimilli, Muralidhar Bundlela, Elizabeth Guo, Adnan M. Mjalli, and Robert C. Andrews; TransTech Pharma Inc., High Point, NC, Patent # US 2008/7459472 (12, 02, 2008).
24. “Aryl Carbonyl Derivatives as Therapeutic Agents-Part-I”; Kalpaty C. Santhosh, Mustafa Guzel, Dharma R. Polisetti, Adnan M. Mjalli, and Robert C. Andrews; TransTech Pharma Inc., High Point, NC, Patent # US 2008/7384967 (06, 10, 2008).
25. “Mandelic Acid Derivatives and Preparation Thereof”; Mustafa Guzel, Scott T. Yokum, and Dharma R. Polisetti; TransTech Pharma Inc., High Point, NC, Patent # WO 2008/051563, (05, 02, 2008).
26. “Exploiting ?-Shielding Interactions of ?6 Arene Chromium (0) Complexes: New Auxiliaries derived from the Biogenic Chiral Pool”; Jane Li, Longfei Xie, Mustafa Guzel, Steven B. Heaton, Dong Ma, Amy E. Kallmerten, and Graham B. Jones; Journal of Organometallic Chem., 2007,. 692, 5459-5473.
27. “Aryl, and Hetoroaryl Compounds, Compositions, and Methods of Use”; Mustafa Guzel, Murty Arimilli, Muraldhar Bundlela, Elizabeth Guo, Adnan M. Mjalli, and Robert C. Andrews; TransTech Pharma Inc., High Point, NC, Patent # US 2005/0059713 (03, 17, 2005).
28. “Novel Aryl Compounds for Antiviral Activity: Amide Derivatives as Therapeutic Agents”; Mustafa Guzel, Murty Arimilli, Muraldhar Bundle, Elizabeth Guo, Adnan M. Mjalli, and Robert C. Andrews; TransTech Pharma Inc., High Point, NC, Patent # WO 2005/014534 (02, 17, 2005).
29. “Aryl Carbonyl Derivatives as Therapeutic Agents”; Kalpaty C. Santhosh, Mustafa Guzel, Dharma R. Polisetti, Adnan M. Mjalli, and Robert C. Andrews; TransTech Pharma Inc., High Point, NC, Patent # US 2004/0122235 (06, 24, 2004).
30. “Aryl Carbonyl Derivatives as Therapeutic Agents”; Kalpaty C. Santhosh, Mustafa Guzel, Dharma R. Polisetti, Adnan M. Mjalli, and Robert C. Andrews; TransTech Pharma Inc., High Point, NC, Patent # WO 2004/002481 (01, 08, 2004).
31. “Novel GlucoKinase Activators: Amide Derivatives as Therapeutic Agents-Part-II”; Mustafa Guzel, Kalpaty C. Santhosh, Dharma R. Polisetti, Adnan M. Mjalli, and Robert C. Andrews; TransTech Pharma Inc., High Point, NC, Patent # US 2003/0171411 (09,11, 2003).
32. “Novel GlucoKinase Activators: Amide Derivatives as Therapeutic Agents-Part-I”; Mustafa Guzel, Kalpaty C. Santhosh, Adnan M. Mjalli, Robert C. Andrews, and Dharma R. Polisetti; TransTech Pharma Inc., High Point, NC; Patent # WO 03/055482 (07, 10, 2003).
33. “Enantioselective Catalysis Using Planar Chiral ?6 Arene Chromium Complexes: 1,2-Diols as Cycloaddition Catalysts”; Graham B. Jones, Mustafa Guzel and Steven B. Heaton; Tetrahedron: Asymmetry, 2000, 11, 4303-4320.
34. “Exploiting ?-Shielding Interactions in a ?6 Arene Complexes Chiral Auxiliary”; Graham B. Jones, and Mustafa Guzel; Tetrahedron Letters, 2000, 41, 4695-4699.
35. “Catalytic Enantioselective Cycloaddtions: A readily Available Diels-Alder Catalyst”; Graham B. Jones, and Mustafa Guzel; Tetrahedron: Asymmetry, 2000, 11, 1267-1271.
36. “Stereoselective Route to Mitosenes via Tricarbonyl ?6 Arene Chromium (0) Complexes”; Graham B. Jones, Mustafa Guzel, and Jude E. Mathews; Tetrahedron Letters, 2000, 41, 1123-1126.
37. “Enantioselective Cycloadditions Catalyzed by Face Resolved Arene Chromium (0) Carbonyl Complexes”; Graham B. Jones, and Mustafa Guzel; Tetrahedron: Asymmetry, 1998, 9, 2023-2026.
38. “Refined Enantioselective Methylation Catalysts: Improved Routes to Bifunctional C5 Synthons”; Graham B. Jones, Mustafa Guzel, and Brant J. Chapman; Tetrahedron: Asymmetry, 1998, 9, 901-905.
39. “On the Origins of Enantioselectivity in Oxazaborolidine Mediated Carbonyl Reductions”; Graham B. Jones, Steven B. Heaton, Brant J. Chapman, and Mustafa Guzel; Tetrahedron: Asymmetry, 1997, 8, 3625-3636.

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Adı Soyadı Dr.Öğr.Üye. İlker KÖSE
E-Posta [email protected]
Detay Öz Geçmiş
Medya

İstanbul Üniversitesi 1999 Gebze Teknik Üniversitesi, Bilgisayar Mühendisliği

Daha Önce Görev Yaptığı Yerler

Ar-Ge Direktörü, CompuGroup Medical A.Ş. (2009-2014); Proje Yöneticisi, Dünya Bankası, Sağlık Bakanlığı (2003-2009); Bilgi İşlem Şefi, İstanbul Ulaşm A.Ş. (1999-2003)

Araştırma Alanları

Sağlıkta veri madenciliği ve yapay sinir ağları uygulamaları, klinik ve yönetimsel karar destek sistemleri, elektronik sağlık kaydının anlamlı kullanımı, sağlık sistem mühendisliği

Seçili Yayınları / Tüm Yayınları

Uluslararası hakemli dergilerde yayınlanan makaleler (SCI & SSCI & Arts and Humanities, Others)
1. Güner Şeyma, Kose, I., Yaratıcı Problem Çözme Tekniği TRIZ’in Uygulama Alanları: Sağlık Hizmetleri Sektöründe Kullanımı İçin Öneriler, Ekonomi İşletme ve Maliye Araştırmaları Dergisi, 2020, 2 (2), Pages 185-205
2. Aksoy, K. Kose, I. The Evaluation of DRG Application from The Point of Healthcare Managers in Turkey, Journal of Health Systems and Policies, 2020, 2 (1), 33-55.
3. Guner, Ş., Kose I., A new approach that proposes TRIZ as a creative problem solving technique in health services, Research Journal of Business and Management, 2020, 2, Pages 67-79.
4. Bolat A. Kose, I., Hayran, O.E., The Evaluation of the Health Information Systems by the Health Information System Managers Within the Research and Teaching Hospitals Affiliated with the University of Health Sciences, Journal of Health Systems and Policies, 1 (3), 2019, Pages 144-173
5. Gençyürek G., Kose, I., The Correlation Analysis of Relative Values of Drugs and the Health Service Tariffs in Private Health Insurance System in Turkey, Journal of Health
Systems and Policies, 2 (1), 2019, Pages 63-77
6. Elmas, B.O., Kose, I., The Correlation Analysis of Relative Values of DRGs and The National Public Health Service Tariffs in Turkey, Journal of Health Systems and Policies 1 (1), 2018, Pages 53-71
7. Kose, I., Gokturk, M., Kilic, K., An interactive machine-learning-based electronic fraud and abuse detection system in healthcare insurance, Applied Soft Computing, Volume 36, November 2015, Pages 283–299

Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceedings) basılan bildiriler
1. Eraltuğ, Z., Üzümoğlu, G., Bolat, Ö., Özkan, E., Nuran, A., Kose I., Effect of closed-loop medication administration on medication billing leakage: A case study, in Proceeding of the AMIA 2020 Virtual Clinical Informatics Conference, May, 2020
2. Bolat, O., Gulenc, N., Ozkan, E., Aydin, N. and Kose, I., The Effects of a Nursing Care Plan Incorporated with a Decision Support System on Ventilator Associated Pneumonia: A Case Study, in Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020) - Volume 5: HEALTHINF, pages 693-698, February, 2020
3. Kose, I., Guner, Ş., Isguzerer, B., Sisli, M.E., A Case Study of the Extended Interactive Innovation Management Model in Insurance Company, European Conference on Innovation and Entrepreneurship 1, 375, 20-21 September 2018, Aveiro, Portugal
4. Kose, I., Akpınar, N., Gürel, M., Arslan, Y., Özer, H., Yurt, N., Kabak, Y., Doğaç, A., “Turkey’s National Health Information System (NHIS)” e-Challenges, 22-24 October 2008, Stokholm, Sweden
5. Kabak, Y., Doğaç, A., Kose, I., Akpınar, N., Gürel, M., Arslan, Y., Özer, H., Yurt N., özçam, A., “The Use of HL7 CDA in the National Health Information System (NHIS) of Turkey”, 9th International HL7 Interoperability Conference IHIC October 2008, Greece
6. Namli T., Aluc G., Sinaci A., Kose I., Akpinar N., Gurel M., Arslan Y., Ozer H., Yurt N., Kirici S., Sabur E., Ozcam A., Dogac A. “Testing the Conformance and Interoperability of NHIS to Turkey’s HL7 Profile” 9th International HL7 Interoperability Conference (IHIC) October 2008, Greece, pp. 63-68.
7. Kose, I., Shvets, N., “Molecular Modeling in the ETOSAR Software”, International Modelling & Stability Conference, May 27-30 2003, Kiev
8. Kose, I., Shvets, N., Soğukpınar, I., “A Problem-Oriented Database as a Tool for the Data on the Structure-Activity Relationships Accumulation, Integration and Exchange”, 12th International Symposium on Artificial Intelligence and Neural Networks July 02-04, 2003, Çanakkale Turkey.

Yazılan uluslararası kitaplar veya kitaplarda bölümler
1. I. Kose, “HIMSS EMRAM Modeli,” in Sağlık Hizmetlerinde Kalite, H. Güler, Ed. İstanbul: İstanbul Medipol Üniversitesi, 2020, pp. 75–88.
2. Kose, I., 2017. “Science And Technology Policies In Turkey.” pp. 1759–74 in Researches on Science And Art in 21st Century Turkey, edited by H. ARAPGIRLIOGLU, A. ATIK, R. L. ELLIOT, and E. TURGEON. Ankara: Gece Kitaplığı
3. Kose, I., . 2018. "Veri Madenciliği, Teori, Uygulama ve Felsefesi", edited by Gökhan Silahtaroglu, Papatya Bilim, Istanbul
4. Kose, I., Kilic, K., 2017. “Büyük Veri Bilimi Ile Sahteciliğin ve Suitsimalin Önlenmesi.” pp. 233–50 in Büyük Veri ve Açık Veri Analitiği: Yöntemler ve Uygulamalar, edited by Ş. Sağıroğlu and O. Koç. Ankara.

Ulusal bilimsel toplantılarda sunulan ve bildiri kitabında basılan bildiriler
1. Kose, I., Göktürk, M., Kilic, K., "Sağlık Geri Ödeme Sistemlerinde Kural Dışı Davranış Tespitinde Aktör-Metâ Odaklı Yaklaşım", VII. Ulusal Tıp Bilişimi Kongresi, 2010, KKTC
2. Kose, I., Göktürk, M., Kilic, K., "Sağlık Sigortası Geri Ödemelerinde Kuraldışı Davranış Tespiti", YAEM 30. Ulusal Kongresi, 2010, İstanbul

Diğer yayınlar

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Adı Soyadı Dr.Öğr.Üye. Muhammet Davut ARPA
E-Posta [email protected]
Detay Öz Geçmiş
Medya

İstanbul Üniversitesi 2011 İstanbul Üniversitesi

Daha Önce Görev Yaptığı Yerler

İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Hastanesi

Araştırma Alanları

Kontrollü Salım Sistemleri, Biyoadezyon, Biyoteknoloji, Nanoteknoloji, İlaçta Patent, Eczacılık Tarihi

Seçili Yayınları / Tüm Yayınları

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Adı Soyadı Dr.Öğr.Üye. Nihal KARAKAŞ
E-Posta [email protected]
Detay Öz Geçmiş
Medya

İstanbul Üniversitesi Deneysel Tıp Araştırma Enstitüsü ve Harvard Tıp Fakültesi, Massachusetts General Hospital

Daha Önce Görev Yaptığı Yerler

Molecular Neurotherapy and Imaging Laboratory (MNIL), Massachusetts General Hospital, Harvard Medical School ve University of Edinburgh, Center for Regenerative Medicine, Adult Cell Therapy Group

Araştırma Alanları

In cancer therapy, toxicity in healthy tissue is a common side effect of current treatment modalities and tumor recurrence is almost inevitable. There is therefore an urgent need to develop novel therapies that act in a robust and cancer-selective manner. In line with this, main focus of our research is developing novel targeting therapy approaches for cancer treatment. One of the succesfull delivery strategy for targeted therapeutics without the limitations of current chemotherapeutic agents, is using stem cells as therapeutic cargo carriers since they have known with their migration capacity towards the tumor sites even including microdeposits. Furthermore, stem cells can be collected individually and engineered to secrete therapeutics which can enable their clinical translation from bench side to bed side. Recently, we are working on engineering stem cells to secrete anti-cancer therapeutics including targeted toxins for the treatment of high grade gliomas and other malignancies. For this aim, we combine bioimaging markers (fluorescence proteins and firefly luciferases) and therapeutic molecules in stem cells using lentiviral vectors. Following pre- and post-implantation of these therapeutically engineered stem cell cargos in mice bearing bioimagable tumors, we then analyse tumor regression by fluorescence/bioluminescence imaging tools and subsequent tissue processing. Furthermore, we investigate the molecular mechanism leading to cancer cell death in culture and to loss in tumor mass in treated mice upon therapeutic stem cell implantation. We study in a close collaboration with Dr. Shah who is the head of Center for Stem Cell Therapeutics and Imaging, Brigham and Woman's Hospital, Harvard Medical School in Boston, U.S. Selected media attentions: - Cancer-killing stem cells engineered in lab (BBC News, October 24, 2014) - Stem cells that can kill cancer have been engineered by scientists (The Independent, October 27, 2014) - Toxin-Secreting Stem Cells May Destroy Brain Tumors From Inside Out (Popular Science, October 27, 2014)

Seçili Yayınları / Tüm Yayınları

• Stuckey DW*, Hingtgen S*, Karakas N, Rich B, Shah K. “Engineering toxin-resistant therapeutic
stem cells to treat brain tumors”, Stem Cells, (Oct. 2014) *authors equally contributed.
• Karakas N, Stuckey DW, Choi SH, Shah K. “ Arming stem cells with targeted toxins breaks
resistance and potentiates TRAIL killing of brain tumors” (in submission)
• Karakas N, Shah K. “Stem Cell Delivery of Targeted Toxins for GBM Therapy (Review)” (in
preperation)
• Isik S, Zaim M, Yildiz MT, Negis Y, Kunduraci T, Karakas N, Arikan G, Cetin G. “DNA
topoisomerase IIß as a molecular switch in neural differentiation of mesenchymal stem cells”,
Annals of Hematology, Sept. 2014
• Mammadov B, Karakas N, Isik S. "Comparison of Long-term Retinoic Acid Based Neural Induction
Methods of Bone Marrow Human Mesenchymal Stem Cells", In vitro Cellular & Developmental
Biology , May 2011
• Kamaci N, Emnacar T, Karakas N, Arikan G, Tsutsui K, Isik. "Selective silencing of DNA
topoisomerase IIß in human mesenchymal stem cells by small interfering RNAs (siRNAs)", Cell
Biology International Reports, March 2011
• Karakas N, Mammadov B, Isik S, "Involvement of Integrin ?5ß1 in Neural Transdifferentiation of
Human Bone Marrow Derived Mesenchymal Stem Cells " (Abstract), Journal of IUBMB Life, May.
2009
• Mammadov B, Karakas N, Isik S, "Emphasis of the Efficient In Vitro Neurogenesis Method For
Bone Marrow Derived Human Mesenchymal Stem Cells" (Abstract), Journal of IUBMB Life, May
2009


Selected media attentions:
- Cancer-killing stem cells engineered in lab (BBC News, October 24, 2014)
- Stem cells that can kill cancer have been engineered by scientists (The Independent, October 27, 2014)
- Toxin-Secreting Stem Cells May Destroy Brain Tumors From Inside Out (Popular Science, October 27, 2014)

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Adı Soyadı Dr.Öğr.Üye. Süleyman ÜÇÜNCÜOĞLU
E-Posta [email protected]
Detay Öz Geçmiş
Medya

Daha Önce Görev Yaptığı Yerler

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Adı Soyadı Dr.Öğr.Üye. Salih GENCER
E-Posta [email protected]
Detay Öz Geçmiş
Medya

Daha Önce Görev Yaptığı Yerler

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