Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| PHARMACOGNOSY II | PHA3214155 | Spring Semester | 2+0 | 2 | 4 |
| Course Program | Pazartesi 11:00-11:45 Pazartesi 12:00-12:45 |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | English |
| Course Level | First Cycle (Bachelor's Degree) |
| Course Type | Required |
| Course Coordinator | Assist.Prof. Şule Nur KARAVUŞ |
| Name of Lecturer(s) | Assist.Prof. Şule Nur KARAVUŞ |
| Assistant(s) | |
| Aim | To provide information about the amino acids, enzymes and alkaloids from plants and other natural sources; explain their biosynthetic pathways, biological activities, and chemical properties. |
| Course Content | This course contains; 1. Definition and Properties of Alkaloids,2. Protoalkaloids,3. Piperidine and Pyridine Alkaloids,4. Tropane Alkaloids,5. Pyrrolizidine and Quinolizidine Alkaloids,6. Indole Alkaloids-Ergoline alkaloids, monoterpenoid indole alkaloids,7. Quinoline Alkaloids,8. Isoquinoline Alkaloids-morphinan alkaloids,9. Isoquinoline Alkaloids-Benzyltetrahydroisoquinolines,10. Isoquinoline Alkaloids-Monoterpenoid isoquinolines,11. Purine bases, Terpenoid and steroid alkaloids,12.Amino Acids, Lectins, Natural protein sweeteners,13.Enzymes, Probiotics and prebiotics,14. Homeopathy, Apitherapy, Hirudotherapy. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1.Define alkaloids, discuss their general properties and chemical classification. | 10, 14, 16, 19, 9 | A, D, E |
| 3.Summarize various functions of amino acids in biosynthetic pathways. | 10, 14, 16, 19, 9 | A, D, E |
| 1.1. Explain pharmacological effects of alkaloids. | 10, 14, 16, 19, 9 | A, D, E |
| 1.2. List alkaloid containing botanical drugs. | 10, 14, 16, 19, 9 | A, D, E |
| 1.3. Evaluate critical issues with the use of ergot alkaloids. | 10, 14, 16, 19, 9 | A, D, E |
| 2. Discuss the use of certain alkaloids as an anticancer agent (e.g., camptothecin, taxol and others). | 10, 14, 16, 19, 9 | A, D, E |
| 2.1. Discuss biological activities of Isoquinoline alkaloids | 10, 14, 16, 19, 9 | A, D, E |
| 2.2. Discuss biological activities of tropane alkaloids | 10, 14, 16, 19, 9 | A, D, E |
| 2.3. Discuss biological activities of terpenoid alkaloids | 10, 14, 16, 19, 9 | A, D, E |
| 3.1. Discuss biological activities of lectins. | 10, 14, 16, 19, 9 | A, D, E |
| 3.2. Classify enzymes and explain their therapeutical uses. | 10, 14, 16, 19, 9 | A, D, E |
| 3.3. Discuss the natural protein sweeteners | 10, 14, 16, 19, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 14: Self Study Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | 1. Definition and Properties of Alkaloids | 1, 2, 3, 4, 5 |
| 2 | 2. Protoalkaloids | 1, 2, 3, 4, 5 |
| 3 | 3. Piperidine and Pyridine Alkaloids | 1, 2, 3, 4, 5 |
| 4 | 4. Tropane Alkaloids | 1, 2, 3, 4, 5 |
| 5 | 5. Pyrrolizidine and Quinolizidine Alkaloids | 1, 2, 3, 4, 5 |
| 6 | 6. Indole Alkaloids-Ergoline alkaloids, monoterpenoid indole alkaloids | 1, 2, 3, 4, 5 |
| 7 | 7. Quinoline Alkaloids | 1, 2, 3, 4, 5 |
| 8 | 8. Isoquinoline Alkaloids-morphinan alkaloids | 1, 2, 3, 4, 5 |
| 9 | 9. Isoquinoline Alkaloids-Benzyltetrahydroisoquinolines | 1, 2, 3, 4, 5 |
| 10 | 10. Isoquinoline Alkaloids-Monoterpenoid isoquinolines | 1, 2, 3, 4, 5 |
| 11 | 11. Purine bases, Terpenoid and steroid alkaloids | 1, 2, 3, 4, 5 |
| 12 | 12.Amino Acids, Lectins, Natural protein sweeteners | 1, 2, 3, 4, 5 |
| 13 | 13.Enzymes, Probiotics and prebiotics | 1, 2, 3, 4, 5 |
| 14 | 14. Homeopathy, Apitherapy, Hirudotherapy | 1, 2, 3, 4, 5 |
| Resources |
| 1- Pharmacognosy II lecture notes will be provided. 2- Pharmacognosy, Phytochemistry, Medicinal Plants, Jean Bruneton, Intercept Ltd., 2nd Edition, 1999. 3- Trease and Evans Pharmacognosy, William C. Evans, Elsevier, 16th Edition, 2009. 4- Farmakognozi Cilt 2, M. Tanker ve N. Tanker, Ankara Üniversitesi Basımevi, Yayın no. 65, 1990. 5- Fundamentals of pharmacognosy and phytotherapy, Churchill Livingstone/ Elsevier, Edinburgh, 2013, c2012. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | PQ-1. Skilfully use information technology to access, follow, evaluate and apply current knowledge in the field of Pharmaceutical Sciences. | X | |||||
| 2 | PQ-2. Have advanced knowledge in APIs and DPs. | X | |||||
| 3 | PQ-3. Collaborate with the experts for collection, interpretation, application and declaration of data in Pharmaceutical Sciences field. | X | |||||
| 4 | PQ-4. Provide best patient counseling services and medication therapy management using his/her knowledge and pharmaceutical information systems to improve the quality of life and safety of patient. | ||||||
| 5 | PQ-5. Capable of organizing and administering a drugstore as per responsibilities prescribed under the Pharmacy Law, using skills, knowledge and advanced technology systems. | X | |||||
| 6 | PQ-6. Skilfully use computer programs and advanced technology related to the Pharmaceutical Sciences. | X | |||||
| 7 | PQ-7. Provide solutions to the professional issues using scientific knowledge and data. | X | |||||
| 8 | PQ-8. Perform identification, quality control and standardization of the drug products. | X | |||||
| 9 | PQ-9. Prepare and implement developmental plans for his/her subordinates, frequently evaluate their progress and make necessary adjustments. | X | |||||
| 10 | PQ-10. Capable of conducting independent studies with his/her advanced knowledge in pharmaceutical sciences, takes responsibilities in professional organizations and efficiently collaborates with the members of his/her own organization as well as other organizations. | X | |||||
| 11 | PQ-11. Clearly show signs of adoption of life-long learning and openness to further development. | X | |||||
| 12 | PQ-12. Critically evaluate their knowledge in pharmaceutical sciences. | X | |||||
| 13 | PQ-13. Closely follow and evaluate the national and international professional developments. | X | |||||
| 14 | PQ-14. Record and document all professional activities and applications. | X | |||||
| 15 | PQ-15. Communicate all necessary information about medicines to patient, medical personnel and public. | X | |||||
| 16 | PQ-16. Proficient in English to communicate and follow current knowledge in pharmaceutical sciences. | X | |||||
| 17 | PQ-17. Inform officials and organizations about the issues with the quality assurance of pharmaceutical products. | X | |||||
| 18 | PQ-18. Actively involve in the preparation of APIs, every stage of the formulation and production of DPs. | X | |||||
| 19 | PQ-19. Knowledgable in the regulatory rules of new drug application, data protection and patent issues and understand their interrelationship. | ||||||
| 20 | PQ-20. Have awareness of his/her duties, rights and responsibilities and act based on Pharmacy Law and high professional ethical standards. | X | |||||
| 21 | PQ-21. Familiar with and actively pursue the personal and public health, environmental, and work safety issues. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 40 | |
| Rate of Final Exam to Success | 60 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 2 | 28 | |||
| Guided Problem Solving | 0 | 0 | 0 | |||
| Resolution of Homework Problems and Submission as a Report | 0 | 0 | 0 | |||
| Term Project | 14 | 2 | 28 | |||
| Presentation of Project / Seminar | 0 | 0 | 0 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 21 | 21 | |||
| General Exam | 1 | 31 | 31 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 108 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(108/30) | 4 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| PHARMACOGNOSY II | PHA3214155 | Spring Semester | 2+0 | 2 | 4 |
| Course Program | Pazartesi 11:00-11:45 Pazartesi 12:00-12:45 |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | English |
| Course Level | First Cycle (Bachelor's Degree) |
| Course Type | Required |
| Course Coordinator | Assist.Prof. Şule Nur KARAVUŞ |
| Name of Lecturer(s) | Assist.Prof. Şule Nur KARAVUŞ |
| Assistant(s) | |
| Aim | To provide information about the amino acids, enzymes and alkaloids from plants and other natural sources; explain their biosynthetic pathways, biological activities, and chemical properties. |
| Course Content | This course contains; 1. Definition and Properties of Alkaloids,2. Protoalkaloids,3. Piperidine and Pyridine Alkaloids,4. Tropane Alkaloids,5. Pyrrolizidine and Quinolizidine Alkaloids,6. Indole Alkaloids-Ergoline alkaloids, monoterpenoid indole alkaloids,7. Quinoline Alkaloids,8. Isoquinoline Alkaloids-morphinan alkaloids,9. Isoquinoline Alkaloids-Benzyltetrahydroisoquinolines,10. Isoquinoline Alkaloids-Monoterpenoid isoquinolines,11. Purine bases, Terpenoid and steroid alkaloids,12.Amino Acids, Lectins, Natural protein sweeteners,13.Enzymes, Probiotics and prebiotics,14. Homeopathy, Apitherapy, Hirudotherapy. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1.Define alkaloids, discuss their general properties and chemical classification. | 10, 14, 16, 19, 9 | A, D, E |
| 3.Summarize various functions of amino acids in biosynthetic pathways. | 10, 14, 16, 19, 9 | A, D, E |
| 1.1. Explain pharmacological effects of alkaloids. | 10, 14, 16, 19, 9 | A, D, E |
| 1.2. List alkaloid containing botanical drugs. | 10, 14, 16, 19, 9 | A, D, E |
| 1.3. Evaluate critical issues with the use of ergot alkaloids. | 10, 14, 16, 19, 9 | A, D, E |
| 2. Discuss the use of certain alkaloids as an anticancer agent (e.g., camptothecin, taxol and others). | 10, 14, 16, 19, 9 | A, D, E |
| 2.1. Discuss biological activities of Isoquinoline alkaloids | 10, 14, 16, 19, 9 | A, D, E |
| 2.2. Discuss biological activities of tropane alkaloids | 10, 14, 16, 19, 9 | A, D, E |
| 2.3. Discuss biological activities of terpenoid alkaloids | 10, 14, 16, 19, 9 | A, D, E |
| 3.1. Discuss biological activities of lectins. | 10, 14, 16, 19, 9 | A, D, E |
| 3.2. Classify enzymes and explain their therapeutical uses. | 10, 14, 16, 19, 9 | A, D, E |
| 3.3. Discuss the natural protein sweeteners | 10, 14, 16, 19, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 14: Self Study Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | 1. Definition and Properties of Alkaloids | 1, 2, 3, 4, 5 |
| 2 | 2. Protoalkaloids | 1, 2, 3, 4, 5 |
| 3 | 3. Piperidine and Pyridine Alkaloids | 1, 2, 3, 4, 5 |
| 4 | 4. Tropane Alkaloids | 1, 2, 3, 4, 5 |
| 5 | 5. Pyrrolizidine and Quinolizidine Alkaloids | 1, 2, 3, 4, 5 |
| 6 | 6. Indole Alkaloids-Ergoline alkaloids, monoterpenoid indole alkaloids | 1, 2, 3, 4, 5 |
| 7 | 7. Quinoline Alkaloids | 1, 2, 3, 4, 5 |
| 8 | 8. Isoquinoline Alkaloids-morphinan alkaloids | 1, 2, 3, 4, 5 |
| 9 | 9. Isoquinoline Alkaloids-Benzyltetrahydroisoquinolines | 1, 2, 3, 4, 5 |
| 10 | 10. Isoquinoline Alkaloids-Monoterpenoid isoquinolines | 1, 2, 3, 4, 5 |
| 11 | 11. Purine bases, Terpenoid and steroid alkaloids | 1, 2, 3, 4, 5 |
| 12 | 12.Amino Acids, Lectins, Natural protein sweeteners | 1, 2, 3, 4, 5 |
| 13 | 13.Enzymes, Probiotics and prebiotics | 1, 2, 3, 4, 5 |
| 14 | 14. Homeopathy, Apitherapy, Hirudotherapy | 1, 2, 3, 4, 5 |
| Resources |
| 1- Pharmacognosy II lecture notes will be provided. 2- Pharmacognosy, Phytochemistry, Medicinal Plants, Jean Bruneton, Intercept Ltd., 2nd Edition, 1999. 3- Trease and Evans Pharmacognosy, William C. Evans, Elsevier, 16th Edition, 2009. 4- Farmakognozi Cilt 2, M. Tanker ve N. Tanker, Ankara Üniversitesi Basımevi, Yayın no. 65, 1990. 5- Fundamentals of pharmacognosy and phytotherapy, Churchill Livingstone/ Elsevier, Edinburgh, 2013, c2012. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | PQ-1. Skilfully use information technology to access, follow, evaluate and apply current knowledge in the field of Pharmaceutical Sciences. | X | |||||
| 2 | PQ-2. Have advanced knowledge in APIs and DPs. | X | |||||
| 3 | PQ-3. Collaborate with the experts for collection, interpretation, application and declaration of data in Pharmaceutical Sciences field. | X | |||||
| 4 | PQ-4. Provide best patient counseling services and medication therapy management using his/her knowledge and pharmaceutical information systems to improve the quality of life and safety of patient. | ||||||
| 5 | PQ-5. Capable of organizing and administering a drugstore as per responsibilities prescribed under the Pharmacy Law, using skills, knowledge and advanced technology systems. | X | |||||
| 6 | PQ-6. Skilfully use computer programs and advanced technology related to the Pharmaceutical Sciences. | X | |||||
| 7 | PQ-7. Provide solutions to the professional issues using scientific knowledge and data. | X | |||||
| 8 | PQ-8. Perform identification, quality control and standardization of the drug products. | X | |||||
| 9 | PQ-9. Prepare and implement developmental plans for his/her subordinates, frequently evaluate their progress and make necessary adjustments. | X | |||||
| 10 | PQ-10. Capable of conducting independent studies with his/her advanced knowledge in pharmaceutical sciences, takes responsibilities in professional organizations and efficiently collaborates with the members of his/her own organization as well as other organizations. | X | |||||
| 11 | PQ-11. Clearly show signs of adoption of life-long learning and openness to further development. | X | |||||
| 12 | PQ-12. Critically evaluate their knowledge in pharmaceutical sciences. | X | |||||
| 13 | PQ-13. Closely follow and evaluate the national and international professional developments. | X | |||||
| 14 | PQ-14. Record and document all professional activities and applications. | X | |||||
| 15 | PQ-15. Communicate all necessary information about medicines to patient, medical personnel and public. | X | |||||
| 16 | PQ-16. Proficient in English to communicate and follow current knowledge in pharmaceutical sciences. | X | |||||
| 17 | PQ-17. Inform officials and organizations about the issues with the quality assurance of pharmaceutical products. | X | |||||
| 18 | PQ-18. Actively involve in the preparation of APIs, every stage of the formulation and production of DPs. | X | |||||
| 19 | PQ-19. Knowledgable in the regulatory rules of new drug application, data protection and patent issues and understand their interrelationship. | ||||||
| 20 | PQ-20. Have awareness of his/her duties, rights and responsibilities and act based on Pharmacy Law and high professional ethical standards. | X | |||||
| 21 | PQ-21. Familiar with and actively pursue the personal and public health, environmental, and work safety issues. | X | |||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 40 | |
| Rate of Final Exam to Success | 60 | |
| Total | 100 | |