Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| MOLECULAR CELL BIOLOGY and BIOCHEMISTRY | MKBD1121930 | Fall Semester | 4+0 | 4 | 10 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Third Cycle (Doctorate Degree) |
| Course Type | Elective |
| Course Coordinator | Res.Assist. Feyza BAYRAMOĞLU |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Esra ÇAĞAVİ, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Deniz DURALI, Assist.Prof. Kıvanç KÖK, Prof.Dr. Türkan YİĞİTBAŞI, Assist.Prof. Salih GENCER, Assist.Prof. Esra Nur YİĞİT, Res.Assist. Feyza BAYRAMOĞLU |
| Assistant(s) | Prof.Dr.Nesrin Emekli, Prof.Dr.Türkan Yiğitbaşı, Prof.Dr.Gürkan Öztürk, Prof.Dr. Süleyman Yıldırım, Doç. Dr. Esra Çağavi, Dr.Öğr.Üyesi Sibel Erdem, Dr.Öğr.Üyesi Deniz Duralı |
| Aim | The aim of this course is to provide an understanding of the structure and basic metabolic activities of the eukaryotic cell as a whole and with a multidisciplinary approach. |
| Course Content | This course contains; Cell Mechanics, Cytoskeleton and Motor Proteins, Interaction with ECM,Cell Cycle, Mitosis, Meiosis and Cancer,Cell survival and death mechanisms, Apoptosis, Necrosis, Autophagy and Aging,Signal transmission mechanisms,Cell Regeneration and Differentiation, Stem Cell and Tissue Repair,Cell Biochemistry,Carbohydrates,Lipids,Proteins and Nucleic Acids,Cell Energy Metabolism, Mitochondria, Cancer and Hunger,Human Microbiome and Taxonomy, Identification of Microorganisms, Immune Organs,Natural Immunity and Its Components, Phases of Immune Response,Acquired Immunity and Its Components,Complement System, Autoimmunity and Viruses. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-Cell Mechanics, Cytoskeleton and Motor Proteins, Interaction with ECM (Prof. Dr. Gürkan Öztürk) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Explains the importance of cell mechanics, cellular formations and their functions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Explains the proteins that form the cytoskeleton and their cellular functions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Defines the motor proteins associated with the cytoskeleton and their functions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4.Explains the structure and functions of structural and adhesive extracellular matrix components with examples. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Cell Cycle, Mitosis, Meiosis and Cancer (Assoc. Prof. Dr. Esra Çağavi) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Defines the stages of the cell cycle in eukaryotic cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Explains the molecular mechanisms of cyclins and cyclin-dependent kinases that control the cell cycle. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Mitoz ve mayoz bölünmenin evrelerini tanımlar. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Explains the molecular mechanisms of cancer and the stages of metastasis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.5.Explains the basic principles of cancer formation, progression and treatment with examples. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3- Cell survival and death mechanisms, Apoptosis, Necrosis, Autophagy and Aging (Dr. Lecturer Turan Demircan) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.Hücre sağkalım ve ölüm mekanizmalarını açıklar | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2.Explains the mechanism of apoptosis, organelles, enzymes and molecular steps of apoptosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3.Defines necrotic death and compares it with apoptotic death. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4.Explains the mechanism of autophagy and the diseases it is associated with with examples. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.5.Defines the intra- and extracellular mechanisms and factors effective in cell aging. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Signal transmission mechanisms (Prof. Dr. Gürkan Öztürk) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1.Explains the molecular principles of signal transmission. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Explains the mechanism of signal transduction mediated by G-protein coupled receptors (GPCR). | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3.Explains the mechanism of receptor tyrosine kinase (RTK)-mediated signal transduction. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5-Cell Regeneration and Differentiation, Stem Cell and Tissue Repair (Assoc. Prof. Dr. Esra Çağavi) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Defines intracellular and extracellular factors that play a role in cell renewal | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Defines stem cells according to embryonic and adult origin and explains with examples. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Explains the production and characterization of induced pluripotent stem cells and their usage areas in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4.Interprets stem cell applications in tissue engineering and repair. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6- Cell Biochemistry (Prof. Dr. Nesrin Emekli) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.1.Explains the entry of dietary nutrients into enterocytes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.2.Explains that resynthesis occurs in enterocytes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.3.Explains energy production from exogenous and endogenous molecules. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.5.Explains the synthesis, degradation and metabolism of molecules that will take part in various reactions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7- Carbohydrates (Prof.Dr.Nesrin Emekli) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.1.Can question the metabolic pathway of carbohydrates | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.2.Explain the fate of glucose in the blood and glycemic control. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8- Lipids (Prof.Dr.Türkan Yiğitbaşı) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.1.Explains the structure and properties of lipids | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.2.Explains the properties and importance of fatty acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.3.Explains essential fatty acids and their role in cardiac diseases. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.4.Explains the importance of lipoproteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.5.Explains the importance of apoproteins in lipid metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.6.Explains alcohols esterified with fatty acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.8.Explains the importance of lipids in energy metabolism | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9- Proteins and Nucleic Acids (Assoc. Prof. Dr. Sibel Erdem) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.1.Explains the structure and properties of Nucleic Acids | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.3.Explains the steps of purine and pyrimidine synthesis and their activation and inhibition. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.4.Explains the degradation of purine and pyrimidine bases and related pathologies. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10-Cell Energy Metabolism, Mitochondria, Cancer and Fasting (Prof. Dr. Türkan Yiğitbaşı) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.1.Explain that cancer cell energy metabolism is different from the normal cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.2.Explains the Warburg effect. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.3.Explains the mechanisms by which cancer cells use excess glucose. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.4.Explain the role of Hypoxia inducible factor-1 alpha (HIF-1α) in the metabolism of cancer cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 11-Human Microbiome and Taxonomy, Identification of Microorganisms, Immune Organs (Prof. Dr. Süleyman Yıldırım, Ass. Prof. Dr. Deniz Duralı) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12-Innate Immunity and Its Components, Phases of the Immune Response, (Prof. Dr. Süleyman Yıldırım, Ass. Prof. Dr. Deniz Duralı) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 13-Adaptive Immunity and Its Components (Prof. Dr. Süleyman Yıldırım, Ass. Prof. Dr. Deniz Duralı) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 14-Complement System, Autoimmunity and Viruses (Prof. Dr. Süleyman Yıldırım, Ass. Prof. Dr. Deniz Duralı) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.4. Explains detoxification of metabolites (urea synthesis, H2O2 etc.). | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.3. Explains the ways of producing energy from glucose | 10, 11, 16, 21, 6, 9 | A, D, E |
| 7.4. Explains the ways of converting glucose into other molecules and other molecules into glucose | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.5. Explains the importance of carbohydrates in energy metabolism | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.7. Questions the importance of lipid metabolism disorders and lipids in the development of atherosclerosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.2. Explains the denova synthesis of purine and pyrimidine bases and the drug metabolisms that act by inhibiting the synthesis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 21: Simulation Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Cell Mechanics, Cytoskeleton and Motor Proteins, Interaction with ECM | |
| 2 | Cell Cycle, Mitosis, Meiosis and Cancer | source 4 |
| 3 | Cell survival and death mechanisms, Apoptosis, Necrosis, Autophagy and Aging | |
| 4 | Signal transmission mechanisms | |
| 5 | Cell Regeneration and Differentiation, Stem Cell and Tissue Repair | source 4 |
| 6 | Cell Biochemistry | 1, 2, 3 |
| 7 | Carbohydrates | 1, 2, 3 |
| 8 | Lipids | 1, 2, 3 |
| 9 | Proteins and Nucleic Acids | 1, 2, 3 |
| 10 | Cell Energy Metabolism, Mitochondria, Cancer and Hunger | 1, 2, 3 |
| 11 | Human Microbiome and Taxonomy, Identification of Microorganisms, Immune Organs | |
| 12 | Natural Immunity and Its Components, Phases of Immune Response | |
| 13 | Acquired Immunity and Its Components | |
| 14 | Complement System, Autoimmunity and Viruses |
| Resources |
| 1.Yiğitbaşı T, Emekli N. Biyokimya Laboratuarı. İstanbul Medipol Üniversitesi, Yayınları, Akademi Basın Yayın, İstanbul 2013. 2.Emekli N. Temel ve Uygulamalı Biyokimya, 4.Baskı. Akademi Basın Yayın, İstanbul 2006. 3.Marks Basic Medical Biochemistry A Clinical Approach.Lieberman M,Marks,AD. Lippiccott Williams Wilkins. 4.Güneş HV, Moleküler Hücre Biyolojisi, 5. Baskı, İstanbul Tıp Kitabevi, 2018. |
| Internet database. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Plans and statistically assesses scientific research, prepares an article for publication in a refereed journal and presents it in a scientific meeting. | ||||||
| 2 | Knows laboratory methods used in the field of Medical Microbiology and designs experimental studies on microorganisms. | ||||||
| 3 | Gains up-to-date scientific knowledge and skills in the field of microbiology and follows the innovations in this field. | ||||||
| 4 | Develops ability to use of devices and tools that serve routine analyses and research purposes in the medical microbiology laboratory | ||||||
| 5 | Statistically analyzes results of experiments at the expert level, (re)evaluates and convincingly defends, if necessary, and presents the results of scientific studies at the in writing or orally. | ||||||
| 6 | Develops ability to write grant proposals | ||||||
| 7 | Solves a scientific and technical problem. | ||||||
| 8 | Participates in meetings related to the field of Medical Microbiology, presents papers, participates in discussions, talks before audiance | ||||||
| 9 | Understands and interprets microbial diseases and their etiology at expert level. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 2 | 28 | |||
| Guided Problem Solving | 14 | 8 | 112 | |||
| Resolution of Homework Problems and Submission as a Report | 2 | 6 | 12 | |||
| Term Project | 2 | 20 | 40 | |||
| Presentation of Project / Seminar | 2 | 10 | 20 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 1 | 35 | 35 | |||
| General Exam | 1 | 53 | 53 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 300 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(300/30) | 10 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| MOLECULAR CELL BIOLOGY and BIOCHEMISTRY | MKBD1121930 | Fall Semester | 4+0 | 4 | 10 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Third Cycle (Doctorate Degree) |
| Course Type | Elective |
| Course Coordinator | Res.Assist. Feyza BAYRAMOĞLU |
| Name of Lecturer(s) | Prof.Dr. Neslin EMEKLİ, Prof.Dr. Esra ÇAĞAVİ, Assoc.Prof. Sultan Sibel ERDEM, Assist.Prof. Deniz DURALI, Assist.Prof. Kıvanç KÖK, Prof.Dr. Türkan YİĞİTBAŞI, Assist.Prof. Salih GENCER, Assist.Prof. Esra Nur YİĞİT, Res.Assist. Feyza BAYRAMOĞLU |
| Assistant(s) | Prof.Dr.Nesrin Emekli, Prof.Dr.Türkan Yiğitbaşı, Prof.Dr.Gürkan Öztürk, Prof.Dr. Süleyman Yıldırım, Doç. Dr. Esra Çağavi, Dr.Öğr.Üyesi Sibel Erdem, Dr.Öğr.Üyesi Deniz Duralı |
| Aim | The aim of this course is to provide an understanding of the structure and basic metabolic activities of the eukaryotic cell as a whole and with a multidisciplinary approach. |
| Course Content | This course contains; Cell Mechanics, Cytoskeleton and Motor Proteins, Interaction with ECM,Cell Cycle, Mitosis, Meiosis and Cancer,Cell survival and death mechanisms, Apoptosis, Necrosis, Autophagy and Aging,Signal transmission mechanisms,Cell Regeneration and Differentiation, Stem Cell and Tissue Repair,Cell Biochemistry,Carbohydrates,Lipids,Proteins and Nucleic Acids,Cell Energy Metabolism, Mitochondria, Cancer and Hunger,Human Microbiome and Taxonomy, Identification of Microorganisms, Immune Organs,Natural Immunity and Its Components, Phases of Immune Response,Acquired Immunity and Its Components,Complement System, Autoimmunity and Viruses. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1-Cell Mechanics, Cytoskeleton and Motor Proteins, Interaction with ECM (Prof. Dr. Gürkan Öztürk) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.1.Explains the importance of cell mechanics, cellular formations and their functions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.2.Explains the proteins that form the cytoskeleton and their cellular functions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.3.Defines the motor proteins associated with the cytoskeleton and their functions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 1.4.Explains the structure and functions of structural and adhesive extracellular matrix components with examples. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2-Cell Cycle, Mitosis, Meiosis and Cancer (Assoc. Prof. Dr. Esra Çağavi) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.1.Defines the stages of the cell cycle in eukaryotic cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.2.Explains the molecular mechanisms of cyclins and cyclin-dependent kinases that control the cell cycle. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.3.Mitoz ve mayoz bölünmenin evrelerini tanımlar. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.4.Explains the molecular mechanisms of cancer and the stages of metastasis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 2.5.Explains the basic principles of cancer formation, progression and treatment with examples. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3- Cell survival and death mechanisms, Apoptosis, Necrosis, Autophagy and Aging (Dr. Lecturer Turan Demircan) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.1.Hücre sağkalım ve ölüm mekanizmalarını açıklar | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.2.Explains the mechanism of apoptosis, organelles, enzymes and molecular steps of apoptosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.3.Defines necrotic death and compares it with apoptotic death. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.4.Explains the mechanism of autophagy and the diseases it is associated with with examples. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 3.5.Defines the intra- and extracellular mechanisms and factors effective in cell aging. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4-Signal transmission mechanisms (Prof. Dr. Gürkan Öztürk) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.1.Explains the molecular principles of signal transmission. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.2.Explains the mechanism of signal transduction mediated by G-protein coupled receptors (GPCR). | 10, 11, 16, 19, 6, 9 | A, D, E |
| 4.3.Explains the mechanism of receptor tyrosine kinase (RTK)-mediated signal transduction. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5-Cell Regeneration and Differentiation, Stem Cell and Tissue Repair (Assoc. Prof. Dr. Esra Çağavi) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.1.Defines intracellular and extracellular factors that play a role in cell renewal | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.2.Defines stem cells according to embryonic and adult origin and explains with examples. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.3.Explains the production and characterization of induced pluripotent stem cells and their usage areas in the laboratory. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 5.4.Interprets stem cell applications in tissue engineering and repair. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6- Cell Biochemistry (Prof. Dr. Nesrin Emekli) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.1.Explains the entry of dietary nutrients into enterocytes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.2.Explains that resynthesis occurs in enterocytes. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.3.Explains energy production from exogenous and endogenous molecules. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.5.Explains the synthesis, degradation and metabolism of molecules that will take part in various reactions. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7- Carbohydrates (Prof.Dr.Nesrin Emekli) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.1.Can question the metabolic pathway of carbohydrates | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.2.Explain the fate of glucose in the blood and glycemic control. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8- Lipids (Prof.Dr.Türkan Yiğitbaşı) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.1.Explains the structure and properties of lipids | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.2.Explains the properties and importance of fatty acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.3.Explains essential fatty acids and their role in cardiac diseases. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.4.Explains the importance of lipoproteins. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.5.Explains the importance of apoproteins in lipid metabolism. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.6.Explains alcohols esterified with fatty acids. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.8.Explains the importance of lipids in energy metabolism | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9- Proteins and Nucleic Acids (Assoc. Prof. Dr. Sibel Erdem) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.1.Explains the structure and properties of Nucleic Acids | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.3.Explains the steps of purine and pyrimidine synthesis and their activation and inhibition. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.4.Explains the degradation of purine and pyrimidine bases and related pathologies. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10-Cell Energy Metabolism, Mitochondria, Cancer and Fasting (Prof. Dr. Türkan Yiğitbaşı) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.1.Explain that cancer cell energy metabolism is different from the normal cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.2.Explains the Warburg effect. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.3.Explains the mechanisms by which cancer cells use excess glucose. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 10.4.Explain the role of Hypoxia inducible factor-1 alpha (HIF-1α) in the metabolism of cancer cells. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 11-Human Microbiome and Taxonomy, Identification of Microorganisms, Immune Organs (Prof. Dr. Süleyman Yıldırım, Ass. Prof. Dr. Deniz Duralı) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 12-Innate Immunity and Its Components, Phases of the Immune Response, (Prof. Dr. Süleyman Yıldırım, Ass. Prof. Dr. Deniz Duralı) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 13-Adaptive Immunity and Its Components (Prof. Dr. Süleyman Yıldırım, Ass. Prof. Dr. Deniz Duralı) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 14-Complement System, Autoimmunity and Viruses (Prof. Dr. Süleyman Yıldırım, Ass. Prof. Dr. Deniz Duralı) | 10, 11, 16, 19, 6, 9 | A, D, E |
| 6.4. Explains detoxification of metabolites (urea synthesis, H2O2 etc.). | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.3. Explains the ways of producing energy from glucose | 10, 11, 16, 21, 6, 9 | A, D, E |
| 7.4. Explains the ways of converting glucose into other molecules and other molecules into glucose | 10, 11, 16, 19, 6, 9 | A, D, E |
| 7.5. Explains the importance of carbohydrates in energy metabolism | 10, 11, 16, 19, 6, 9 | A, D, E |
| 8.7. Questions the importance of lipid metabolism disorders and lipids in the development of atherosclerosis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| 9.2. Explains the denova synthesis of purine and pyrimidine bases and the drug metabolisms that act by inhibiting the synthesis. | 10, 11, 16, 19, 6, 9 | A, D, E |
| Teaching Methods: | 10: Discussion Method, 11: Demonstration Method, 16: Question - Answer Technique, 19: Brainstorming Technique, 21: Simulation Technique, 6: Experiential Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, D: Oral Exam, E: Homework |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Cell Mechanics, Cytoskeleton and Motor Proteins, Interaction with ECM | |
| 2 | Cell Cycle, Mitosis, Meiosis and Cancer | source 4 |
| 3 | Cell survival and death mechanisms, Apoptosis, Necrosis, Autophagy and Aging | |
| 4 | Signal transmission mechanisms | |
| 5 | Cell Regeneration and Differentiation, Stem Cell and Tissue Repair | source 4 |
| 6 | Cell Biochemistry | 1, 2, 3 |
| 7 | Carbohydrates | 1, 2, 3 |
| 8 | Lipids | 1, 2, 3 |
| 9 | Proteins and Nucleic Acids | 1, 2, 3 |
| 10 | Cell Energy Metabolism, Mitochondria, Cancer and Hunger | 1, 2, 3 |
| 11 | Human Microbiome and Taxonomy, Identification of Microorganisms, Immune Organs | |
| 12 | Natural Immunity and Its Components, Phases of Immune Response | |
| 13 | Acquired Immunity and Its Components | |
| 14 | Complement System, Autoimmunity and Viruses |
| Resources |
| 1.Yiğitbaşı T, Emekli N. Biyokimya Laboratuarı. İstanbul Medipol Üniversitesi, Yayınları, Akademi Basın Yayın, İstanbul 2013. 2.Emekli N. Temel ve Uygulamalı Biyokimya, 4.Baskı. Akademi Basın Yayın, İstanbul 2006. 3.Marks Basic Medical Biochemistry A Clinical Approach.Lieberman M,Marks,AD. Lippiccott Williams Wilkins. 4.Güneş HV, Moleküler Hücre Biyolojisi, 5. Baskı, İstanbul Tıp Kitabevi, 2018. |
| Internet database. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Plans and statistically assesses scientific research, prepares an article for publication in a refereed journal and presents it in a scientific meeting. | ||||||
| 2 | Knows laboratory methods used in the field of Medical Microbiology and designs experimental studies on microorganisms. | ||||||
| 3 | Gains up-to-date scientific knowledge and skills in the field of microbiology and follows the innovations in this field. | ||||||
| 4 | Develops ability to use of devices and tools that serve routine analyses and research purposes in the medical microbiology laboratory | ||||||
| 5 | Statistically analyzes results of experiments at the expert level, (re)evaluates and convincingly defends, if necessary, and presents the results of scientific studies at the in writing or orally. | ||||||
| 6 | Develops ability to write grant proposals | ||||||
| 7 | Solves a scientific and technical problem. | ||||||
| 8 | Participates in meetings related to the field of Medical Microbiology, presents papers, participates in discussions, talks before audiance | ||||||
| 9 | Understands and interprets microbial diseases and their etiology at expert level. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |