Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| MEDICAL BIOLOGY & GENETICS | - | Yearly | 66+10 | - | 5 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | English |
| Course Level | First Cycle (Bachelor's Degree) |
| Course Type | Committee Course |
| Course Coordinator | Prof.Dr. Esra ÇAĞAVİ |
| Name of Lecturer(s) | Prof.Dr. Esra ÇAĞAVİ, Assist.Prof. Berrak ÇAĞLAYAN, Assist.Prof. Salih GENCER, Assist.Prof. Yasemin YOZGAT BYRNE |
| Assistant(s) | None |
| Aim | The aim of this course is to define and evaluate the fundamental concepts in medical biology and medical genetics, that will lay the foundation for first year medical students for understanding of basic cellular mechanisms as well as associating the dysfunctional molecular mechanisms with human diseases. |
| Course Content | This course contains; Fundamentals of life - the cell,Chemical principles of the cell biology and biosynthesis,Protein structure and function,Genetic material of the cell - DNA, chromosomes and the genome,DNA replication and repair,RNA structure and transcription,Genetic code and tranlation,Control of gene expression and genetic switches-I,Control of gene expression and genetic switches-II,Epigenetics and epigenome,Molecular techniques and clinical applications,The structure and function of cellular membranes and transport across the membrane,Cellular compartments: Organelles-I,Cellular compartments: Organelles-II,Cellular compartments: Organelles-III,Vesicular transport within the cell,Endocytosis, exocytosis and membrane transport,Cell Signaling -I,Cell Signaling -II,Cytoskeleton and motor proteins,Cell adhesion, junctions and extracellular matrix,Cell cycle,Cell senescence and cell death,Developmental biology and organ regeneration,Stem cells and regenerative medicine,Cancer biology and molecular basis of cancer,Current therapeutic approaches and cancer therapy,Fundamentals of medical genetics,Mendelian/non-mendelian/population genetics,Principles of autosomal genetic inheritance,Principles of genetic inheritance sex chromosomes,Gonosomal and autosomal chromosomal abnormalities,Prenatal testing and genetic counseling. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 10, 12, 14, 16, 17, 19, 3, 37, 4, 9 | A, E, G |
| Teaching Methods: | 10: Discussion Method, 12: Problem Solving Method, 14: Self Study Method, 16: Question - Answer Technique, 17: Experimental Technique, 19: Brainstorming Technique, 3: Problem Baded Learning Model, 37: Computer-Internet Supported Instruction, 4: Inquiry-Based Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, E: Homework, G: Quiz |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Fundamentals of life - the cell | |
| 2 | Chemical principles of the cell biology and biosynthesis | |
| 3 | Protein structure and function | |
| 4 | Genetic material of the cell - DNA, chromosomes and the genome | |
| 5 | DNA replication and repair | |
| 6 | RNA structure and transcription | |
| 7 | Genetic code and tranlation | |
| 8 | Control of gene expression and genetic switches-I | |
| 9 | Control of gene expression and genetic switches-II | |
| 10 | Epigenetics and epigenome | |
| 11 | Molecular techniques and clinical applications | |
| 12 | The structure and function of cellular membranes and transport across the membrane | |
| 13 | Cellular compartments: Organelles-I | |
| 14 | Cellular compartments: Organelles-II | |
| 15 | Cellular compartments: Organelles-III | |
| 16 | Vesicular transport within the cell | |
| 17 | Endocytosis, exocytosis and membrane transport | |
| 18 | Cell Signaling -I | |
| 19 | Cell Signaling -II | |
| 20 | Cytoskeleton and motor proteins | |
| 21 | Cell adhesion, junctions and extracellular matrix | |
| 22 | Cell cycle | |
| 23 | Cell senescence and cell death | |
| 24 | Developmental biology and organ regeneration | |
| 25 | Stem cells and regenerative medicine | |
| 26 | Cancer biology and molecular basis of cancer | |
| 27 | Current therapeutic approaches and cancer therapy | |
| 28 | Fundamentals of medical genetics | |
| 29 | Mendelian/non-mendelian/population genetics | |
| 30 | Principles of autosomal genetic inheritance | |
| 31 | Principles of genetic inheritance sex chromosomes | |
| 32 | Gonosomal and autosomal chromosomal abnormalities | |
| 33 | Prenatal testing and genetic counseling |
| Resources |
| Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter “Essential Cell Biology” Fourth Edition, Garland Science Publishers, USA, 2013. |
| 1. Presentations of lecture notes 2. Stephen R Goodman “Medical Cell Biology”, Third Edition, Elsevier, USA, 2007. 3. Alberts, Johnson, Lewis, Raff, Roberts, Walter “Molecular Biology of the Cell” Sixth Edition, Garland Science Publishers, USA, 2013. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | PQ1: Knows the morphological and functional normal and abnormal structure of human body. | ||||||
| 2 | PQ2: Knows the essential ways of determining the underlying causes of the pathologies with basic scientific approaches and the diagnoses of illnesses and disorders. | ||||||
| 3 | PQ3: Knows the reasons for illnesses, the ways of protection, and the methods of promotion and improvement of public health. | ||||||
| 4 | PQ4: Knows the methods of advancing his/her knowledge about health and its practice. | ||||||
| 5 | PQ5: Accesses, interprets and applies the advanced interdisciplinary information related to health. | ||||||
| 6 | PQ6: Performs a complete clinical examination of the human body, both morphologically and functionally and defines the problems. | ||||||
| 7 | PQ7: Interprets examination data for diagnoses, compares with clinical data, and provides solutions. | ||||||
| 8 | PQ8: Selects and applies appropriate tools for promotion and improvement of individual and public health. | ||||||
| 9 | PQ9: Plans and conducts an advanced study of health independently. | ||||||
| 10 | PQ10: Takes responsibility individually and as a team member to solve the problems encountered in the promotion and improvement of individual and public health. | ||||||
| 11 | PQ11: Takes responsibility for any intervention on the human body for the diagnosis and treatment. | ||||||
| 12 | PQ12: Determines personal learning requirements and decides and develops a positive lifelong learning attitude. | ||||||
| 13 | PQ13: Evaluates the information gained in the field of health with a critical approach. | ||||||
| 14 | PQ14: Informs the patient, the relevant people and institutions, and the public about the health problem and conveys recommendations of solutions in writing and/or verbally. | ||||||
| 15 | PQ15: Shares their recommendations on promotion and improvement of health with interdisciplinary experts by supporting with data. | ||||||
| 16 | PQ16: Uses English at least at the General Level of European Language Portfolio B1, follows resources in his/her field and communicates. | ||||||
| 17 | PQ17: Uses computer software, information, and communication technologies at least at the Advanced Level of European Computer Operating License. | ||||||
| 18 | PQ18: Acts in accordance with social, scientific, cultural and ethical values in the stages of obtaining, interpreting, applying and announcing the data related to the field of health. | ||||||
| 19 | PQ19: Develops strategy, policy and implementation plans on health issues and evaluate the results obtained the framework of quality processes. | ||||||
| 20 | PQ20: Systematically shares his/her works on promoting and improving health with quantitative and qualitative data and interdisciplinary experts. | ||||||
| 21 | PQ21: Has sufficient awareness on occupational health and safety issues. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 40 | |
| Rate of Final Exam to Success | 60 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 0 | 0 | 0 | |||
| Guided Problem Solving | 0 | 0 | 0 | |||
| Resolution of Homework Problems and Submission as a Report | 0 | 0 | 0 | |||
| Term Project | 0 | 0 | 0 | |||
| Presentation of Project / Seminar | 0 | 0 | 0 | |||
| Quiz | 0 | 0 | 0 | |||
| Midterm Exam | 0 | 0 | 0 | |||
| General Exam | 0 | 0 | 0 | |||
| Performance Task, Maintenance Plan | 0 | 0 | 0 | |||
| Total Workload(Hour) | 0 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(0/30) | 0 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| MEDICAL BIOLOGY & GENETICS | - | Yearly | 66+10 | - | 5 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | English |
| Course Level | First Cycle (Bachelor's Degree) |
| Course Type | Committee Course |
| Course Coordinator | Prof.Dr. Esra ÇAĞAVİ |
| Name of Lecturer(s) | Prof.Dr. Esra ÇAĞAVİ, Assist.Prof. Berrak ÇAĞLAYAN, Assist.Prof. Salih GENCER, Assist.Prof. Yasemin YOZGAT BYRNE |
| Assistant(s) | None |
| Aim | The aim of this course is to define and evaluate the fundamental concepts in medical biology and medical genetics, that will lay the foundation for first year medical students for understanding of basic cellular mechanisms as well as associating the dysfunctional molecular mechanisms with human diseases. |
| Course Content | This course contains; Fundamentals of life - the cell,Chemical principles of the cell biology and biosynthesis,Protein structure and function,Genetic material of the cell - DNA, chromosomes and the genome,DNA replication and repair,RNA structure and transcription,Genetic code and tranlation,Control of gene expression and genetic switches-I,Control of gene expression and genetic switches-II,Epigenetics and epigenome,Molecular techniques and clinical applications,The structure and function of cellular membranes and transport across the membrane,Cellular compartments: Organelles-I,Cellular compartments: Organelles-II,Cellular compartments: Organelles-III,Vesicular transport within the cell,Endocytosis, exocytosis and membrane transport,Cell Signaling -I,Cell Signaling -II,Cytoskeleton and motor proteins,Cell adhesion, junctions and extracellular matrix,Cell cycle,Cell senescence and cell death,Developmental biology and organ regeneration,Stem cells and regenerative medicine,Cancer biology and molecular basis of cancer,Current therapeutic approaches and cancer therapy,Fundamentals of medical genetics,Mendelian/non-mendelian/population genetics,Principles of autosomal genetic inheritance,Principles of genetic inheritance sex chromosomes,Gonosomal and autosomal chromosomal abnormalities,Prenatal testing and genetic counseling. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 10, 12, 14, 16, 17, 19, 3, 37, 4, 9 | A, E, G |
| Teaching Methods: | 10: Discussion Method, 12: Problem Solving Method, 14: Self Study Method, 16: Question - Answer Technique, 17: Experimental Technique, 19: Brainstorming Technique, 3: Problem Baded Learning Model, 37: Computer-Internet Supported Instruction, 4: Inquiry-Based Learning, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam, E: Homework, G: Quiz |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Fundamentals of life - the cell | |
| 2 | Chemical principles of the cell biology and biosynthesis | |
| 3 | Protein structure and function | |
| 4 | Genetic material of the cell - DNA, chromosomes and the genome | |
| 5 | DNA replication and repair | |
| 6 | RNA structure and transcription | |
| 7 | Genetic code and tranlation | |
| 8 | Control of gene expression and genetic switches-I | |
| 9 | Control of gene expression and genetic switches-II | |
| 10 | Epigenetics and epigenome | |
| 11 | Molecular techniques and clinical applications | |
| 12 | The structure and function of cellular membranes and transport across the membrane | |
| 13 | Cellular compartments: Organelles-I | |
| 14 | Cellular compartments: Organelles-II | |
| 15 | Cellular compartments: Organelles-III | |
| 16 | Vesicular transport within the cell | |
| 17 | Endocytosis, exocytosis and membrane transport | |
| 18 | Cell Signaling -I | |
| 19 | Cell Signaling -II | |
| 20 | Cytoskeleton and motor proteins | |
| 21 | Cell adhesion, junctions and extracellular matrix | |
| 22 | Cell cycle | |
| 23 | Cell senescence and cell death | |
| 24 | Developmental biology and organ regeneration | |
| 25 | Stem cells and regenerative medicine | |
| 26 | Cancer biology and molecular basis of cancer | |
| 27 | Current therapeutic approaches and cancer therapy | |
| 28 | Fundamentals of medical genetics | |
| 29 | Mendelian/non-mendelian/population genetics | |
| 30 | Principles of autosomal genetic inheritance | |
| 31 | Principles of genetic inheritance sex chromosomes | |
| 32 | Gonosomal and autosomal chromosomal abnormalities | |
| 33 | Prenatal testing and genetic counseling |
| Resources |
| Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter “Essential Cell Biology” Fourth Edition, Garland Science Publishers, USA, 2013. |
| 1. Presentations of lecture notes 2. Stephen R Goodman “Medical Cell Biology”, Third Edition, Elsevier, USA, 2007. 3. Alberts, Johnson, Lewis, Raff, Roberts, Walter “Molecular Biology of the Cell” Sixth Edition, Garland Science Publishers, USA, 2013. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | PQ1: Knows the morphological and functional normal and abnormal structure of human body. | ||||||
| 2 | PQ2: Knows the essential ways of determining the underlying causes of the pathologies with basic scientific approaches and the diagnoses of illnesses and disorders. | ||||||
| 3 | PQ3: Knows the reasons for illnesses, the ways of protection, and the methods of promotion and improvement of public health. | ||||||
| 4 | PQ4: Knows the methods of advancing his/her knowledge about health and its practice. | ||||||
| 5 | PQ5: Accesses, interprets and applies the advanced interdisciplinary information related to health. | ||||||
| 6 | PQ6: Performs a complete clinical examination of the human body, both morphologically and functionally and defines the problems. | ||||||
| 7 | PQ7: Interprets examination data for diagnoses, compares with clinical data, and provides solutions. | ||||||
| 8 | PQ8: Selects and applies appropriate tools for promotion and improvement of individual and public health. | ||||||
| 9 | PQ9: Plans and conducts an advanced study of health independently. | ||||||
| 10 | PQ10: Takes responsibility individually and as a team member to solve the problems encountered in the promotion and improvement of individual and public health. | ||||||
| 11 | PQ11: Takes responsibility for any intervention on the human body for the diagnosis and treatment. | ||||||
| 12 | PQ12: Determines personal learning requirements and decides and develops a positive lifelong learning attitude. | ||||||
| 13 | PQ13: Evaluates the information gained in the field of health with a critical approach. | ||||||
| 14 | PQ14: Informs the patient, the relevant people and institutions, and the public about the health problem and conveys recommendations of solutions in writing and/or verbally. | ||||||
| 15 | PQ15: Shares their recommendations on promotion and improvement of health with interdisciplinary experts by supporting with data. | ||||||
| 16 | PQ16: Uses English at least at the General Level of European Language Portfolio B1, follows resources in his/her field and communicates. | ||||||
| 17 | PQ17: Uses computer software, information, and communication technologies at least at the Advanced Level of European Computer Operating License. | ||||||
| 18 | PQ18: Acts in accordance with social, scientific, cultural and ethical values in the stages of obtaining, interpreting, applying and announcing the data related to the field of health. | ||||||
| 19 | PQ19: Develops strategy, policy and implementation plans on health issues and evaluate the results obtained the framework of quality processes. | ||||||
| 20 | PQ20: Systematically shares his/her works on promoting and improving health with quantitative and qualitative data and interdisciplinary experts. | ||||||
| 21 | PQ21: Has sufficient awareness on occupational health and safety issues. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 40 | |
| Rate of Final Exam to Success | 60 | |
| Total | 100 | |