Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| CLINICAL TOXICOLOGY | - | Spring Semester | 2+0 | 2 | 6 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | Prof.Dr. Gülden Zehra OMURTAG |
| Name of Lecturer(s) | Prof.Dr. Gülden Zehra OMURTAG |
| Assistant(s) | |
| Aim | It is aimed to understand the general treatment principles in poisoning, to define side effects and allergic reactions, and to teach the role of genetic factors and adverse drug reactions in the emergence of toxicity. |
| Course Content | This course contains; Introduction to Clinical Toxicology,First Aid in Poisonings,Acceleration of Elimination and Antidote Mechanisms in Poisonings,Analgesic Drugs, Central Nervous System Intoxication and Treatments,Intoxication with Vitamins and Antihistamine Drugs and Their Treatment,Intoxication with Cardiovascular Drugs and Their Treatment,Substance Abuse and Drug Abuse,Preclinical and Clinical Studies,Pharmacovigilance Applications,Herbal Poisons and Their Treatment in Poisoning,Fungal Poisonings and Treatments,Poisoning with Mycotoxins,Poisoning with Organic Solvents,Poisoning with Pesticides and Their Treatment. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1. Defines toxicology. | 16, 9 | A |
| 1.1 Explains the concept of dose and the ways poisons enter the body and are absorbed. | 16, 9 | A |
| 1.2. Define the terms allergy, polymorphism and pharmacovigilance. | 16, 9 | A |
| 2. Explains acute and chronic poisoning. | 16, 9 | A |
| 2.2. It shows possible treatment schemes by evaluating treatment methods and antidotes that change toxicokinetic parameters in poisonings. | 16, 9 | A |
| 2.3. Explains first aid steps, specific antidotes and treatment principles. | 16, 9 | A |
| 3. Explains the absorption, distribution, metabolism and elimination steps of poisons. | 16, 9 | A |
| 3. Evaluates drugs in terms of pharmacodynamics, pharmacokinetics, and toxicology. | 16, 9 | A |
| 3.1. Evaluates the toxic effects, side effects, and interactions of drugs used in allergy treatment with other drugs. | 16, 9 | A |
| 3.2. Evaluates the toxic effects, side effects and interactions of analgesics with other drugs. | 16, 9 | A |
| 3.3. Evaluates the toxic effects, side effects and interactions of drugs acting on the central nervous system with other drugs. | 16, 9 | A |
| 3.4. Evaluates the toxic effects, side effects, and interactions of drugs effective on the cardiovascular system with other drugs. | 16, 9 | A |
| 4. Explains the toxic effects that occur or are likely to occur due to the use of herbal products and foods. | 16, 9 | A |
| 4.1. Explains mushroom poisoning and treatments. | 16, 9 | A |
| 4.2. Evaluates mycotoxins, the conditions that lead to their formation, their effects, and the diseases they cause. | 16, 9 | A |
| 4.3. Evaluates poisoning with pesticides and findings of exposure through residues. | 16, 9 | A |
| 5. Classifies addictive substances according to their toxic effect mechanisms and method of use. | 16, 9 | A |
| 5.1. Gives examples of drugs that are susceptible to abuse. Explains legal regulations. | 16, 9 | A |
| 6. Defines the studies of Phases 1,2,3,4. | 16, 9 | A |
| 6.1. Evaluates by comparing animal experiments performed in preclinics and data obtained in the clinic. | 16, 9 | A |
| Teaching Methods: | 16: Question - Answer Technique, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Introduction to Clinical Toxicology | 1,2 |
| 2 | First Aid in Poisonings | 1,2 |
| 3 | Acceleration of Elimination and Antidote Mechanisms in Poisonings | 1,2,3 |
| 4 | Analgesic Drugs, Central Nervous System Intoxication and Treatments | 1 |
| 5 | Intoxication with Vitamins and Antihistamine Drugs and Their Treatment | 1,2 |
| 6 | Intoxication with Cardiovascular Drugs and Their Treatment | 1,2,3 |
| 7 | Substance Abuse and Drug Abuse | 1 |
| 8 | Preclinical and Clinical Studies | 1 |
| 9 | Pharmacovigilance Applications | 1,2 |
| 10 | Herbal Poisons and Their Treatment in Poisoning | 1,2 |
| 11 | Fungal Poisonings and Treatments | 1,2 |
| 12 | Poisoning with Mycotoxins | 1,2,3 |
| 13 | Poisoning with Organic Solvents | 1 |
| 14 | Poisoning with Pesticides and Their Treatment | 1,2,3 |
| Resources |
| 1. Lecture notes. 2. Ellenhorn MJ, Ellenhorn's Medical Toxicology, Second Edition, Williams & Wilkins, London, 1997. 3.Klaassen CD, Watkins III JB, Casarett & Doull's Essentials of Toxicology, The McGraw-Hill Companies, USA, 2003. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | PY-1. Knows about accessing the scientific information in the field of clinical pharmacy, monitoring, evaluating, and implementing the current literature | X | |||||
| 2 | PY-2. Has the advanced knowledge of creating patient profiles, patient education, and medication counseling. | X | |||||
| 3 | PY-3. Cooperates with persons in relevant disciplines at the stages of collecting, interpreting, implementing, and announcing results of data related to the clinical pharmacy field | X | |||||
| 4 | PY-4. Uses the knowledge and equipment related to administering medicine to patients and the use of the drug. Gives pharmaceutical care service by providing rational and safe drug use with the duty of observance and supervision. | X | |||||
| 5 | PY-5. Acquires administrative and technical stand-by equipment in the areas where the clinical pharmacy is responsible for and achieves hospital pharmacy practices properly. | X | |||||
| 6 | PY-6. Produces solutions to the problems in the field of clinical pharmacy in the direction of scientific data/ scientific evidence. | X | |||||
| 7 | PY-7. Plans, manages, watches the process, and evaluates activities that oriented improvements of employees as part of a project. | ||||||
| 8 | PY-8. Carries out a study independently by using advanced level knowledge about the field of clinical pharmacy and takes responsibility as a team member in cooperation with other occupational groups working in this field. | ||||||
| 9 | PY-9. Demonstrates embarking on lifelong learning, open for improvement, and continue this behavior. | ||||||
| 10 | PY-10. Follows and evaluates national and international developments in the field of clinical pharmacy. | X | |||||
| 11 | PY-11. Safely documents and keeps track of professional activities and practices. | X | |||||
| 12 | PY-12. Provides information to the patience, healthcare personnel, and society on every drug-related issue. | ||||||
| 13 | PY-13. Informs relevant persons and institutions in the fields of quality assurance of pharmaceutical products | ||||||
| 14 | PY-14. Behaves according to the legislation and professional ethics related to duty, right, and responsibilities as an individual. | ||||||
| 15 | PY-15. Has sufficient consciousness in the field of individual and public health, environmental protection, and job security and applies it. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |
| ECTS / Workload Table | ||||||
| Activities | Number of | Duration(Hour) | Total Workload(Hour) | |||
| Course Hours | 14 | 2 | 28 | |||
| Guided Problem Solving | 14 | 1 | 14 | |||
| Resolution of Homework Problems and Submission as a Report | 14 | 2 | 28 | |||
| Term Project | 0 | 0 | 0 | |||
| Presentation of Project / Seminar | 2 | 14 | 28 | |||
| Quiz | 1 | 10 | 10 | |||
| Midterm Exam | 1 | 14 | 14 | |||
| General Exam | 1 | 30 | 30 | |||
| Performance Task, Maintenance Plan | 2 | 14 | 28 | |||
| Total Workload(Hour) | 180 | |||||
| Dersin AKTS Kredisi = Toplam İş Yükü (Saat)/30*=(180/30) | 6 | |||||
| ECTS of the course: 30 hours of work is counted as 1 ECTS credit. | ||||||
Detail Informations of the Course
Course Description
| Course | Code | Semester | T+P (Hour) | Credit | ECTS |
|---|---|---|---|---|---|
| CLINICAL TOXICOLOGY | - | Spring Semester | 2+0 | 2 | 6 |
| Course Program |
| Prerequisites Courses | |
| Recommended Elective Courses |
| Language of Course | Turkish |
| Course Level | Second Cycle (Master's Degree) |
| Course Type | Elective |
| Course Coordinator | Prof.Dr. Gülden Zehra OMURTAG |
| Name of Lecturer(s) | Prof.Dr. Gülden Zehra OMURTAG |
| Assistant(s) | |
| Aim | It is aimed to understand the general treatment principles in poisoning, to define side effects and allergic reactions, and to teach the role of genetic factors and adverse drug reactions in the emergence of toxicity. |
| Course Content | This course contains; Introduction to Clinical Toxicology,First Aid in Poisonings,Acceleration of Elimination and Antidote Mechanisms in Poisonings,Analgesic Drugs, Central Nervous System Intoxication and Treatments,Intoxication with Vitamins and Antihistamine Drugs and Their Treatment,Intoxication with Cardiovascular Drugs and Their Treatment,Substance Abuse and Drug Abuse,Preclinical and Clinical Studies,Pharmacovigilance Applications,Herbal Poisons and Their Treatment in Poisoning,Fungal Poisonings and Treatments,Poisoning with Mycotoxins,Poisoning with Organic Solvents,Poisoning with Pesticides and Their Treatment. |
| Dersin Öğrenme Kazanımları | Teaching Methods | Assessment Methods |
| 1. Defines toxicology. | 16, 9 | A |
| 1.1 Explains the concept of dose and the ways poisons enter the body and are absorbed. | 16, 9 | A |
| 1.2. Define the terms allergy, polymorphism and pharmacovigilance. | 16, 9 | A |
| 2. Explains acute and chronic poisoning. | 16, 9 | A |
| 2.2. It shows possible treatment schemes by evaluating treatment methods and antidotes that change toxicokinetic parameters in poisonings. | 16, 9 | A |
| 2.3. Explains first aid steps, specific antidotes and treatment principles. | 16, 9 | A |
| 3. Explains the absorption, distribution, metabolism and elimination steps of poisons. | 16, 9 | A |
| 3. Evaluates drugs in terms of pharmacodynamics, pharmacokinetics, and toxicology. | 16, 9 | A |
| 3.1. Evaluates the toxic effects, side effects, and interactions of drugs used in allergy treatment with other drugs. | 16, 9 | A |
| 3.2. Evaluates the toxic effects, side effects and interactions of analgesics with other drugs. | 16, 9 | A |
| 3.3. Evaluates the toxic effects, side effects and interactions of drugs acting on the central nervous system with other drugs. | 16, 9 | A |
| 3.4. Evaluates the toxic effects, side effects, and interactions of drugs effective on the cardiovascular system with other drugs. | 16, 9 | A |
| 4. Explains the toxic effects that occur or are likely to occur due to the use of herbal products and foods. | 16, 9 | A |
| 4.1. Explains mushroom poisoning and treatments. | 16, 9 | A |
| 4.2. Evaluates mycotoxins, the conditions that lead to their formation, their effects, and the diseases they cause. | 16, 9 | A |
| 4.3. Evaluates poisoning with pesticides and findings of exposure through residues. | 16, 9 | A |
| 5. Classifies addictive substances according to their toxic effect mechanisms and method of use. | 16, 9 | A |
| 5.1. Gives examples of drugs that are susceptible to abuse. Explains legal regulations. | 16, 9 | A |
| 6. Defines the studies of Phases 1,2,3,4. | 16, 9 | A |
| 6.1. Evaluates by comparing animal experiments performed in preclinics and data obtained in the clinic. | 16, 9 | A |
| Teaching Methods: | 16: Question - Answer Technique, 9: Lecture Method |
| Assessment Methods: | A: Traditional Written Exam |
Course Outline
| Order | Subjects | Preliminary Work |
|---|---|---|
| 1 | Introduction to Clinical Toxicology | 1,2 |
| 2 | First Aid in Poisonings | 1,2 |
| 3 | Acceleration of Elimination and Antidote Mechanisms in Poisonings | 1,2,3 |
| 4 | Analgesic Drugs, Central Nervous System Intoxication and Treatments | 1 |
| 5 | Intoxication with Vitamins and Antihistamine Drugs and Their Treatment | 1,2 |
| 6 | Intoxication with Cardiovascular Drugs and Their Treatment | 1,2,3 |
| 7 | Substance Abuse and Drug Abuse | 1 |
| 8 | Preclinical and Clinical Studies | 1 |
| 9 | Pharmacovigilance Applications | 1,2 |
| 10 | Herbal Poisons and Their Treatment in Poisoning | 1,2 |
| 11 | Fungal Poisonings and Treatments | 1,2 |
| 12 | Poisoning with Mycotoxins | 1,2,3 |
| 13 | Poisoning with Organic Solvents | 1 |
| 14 | Poisoning with Pesticides and Their Treatment | 1,2,3 |
| Resources |
| 1. Lecture notes. 2. Ellenhorn MJ, Ellenhorn's Medical Toxicology, Second Edition, Williams & Wilkins, London, 1997. 3.Klaassen CD, Watkins III JB, Casarett & Doull's Essentials of Toxicology, The McGraw-Hill Companies, USA, 2003. |
Course Contribution to Program Qualifications
| Course Contribution to Program Qualifications | |||||||
| No | Program Qualification | Contribution Level | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | PY-1. Knows about accessing the scientific information in the field of clinical pharmacy, monitoring, evaluating, and implementing the current literature | X | |||||
| 2 | PY-2. Has the advanced knowledge of creating patient profiles, patient education, and medication counseling. | X | |||||
| 3 | PY-3. Cooperates with persons in relevant disciplines at the stages of collecting, interpreting, implementing, and announcing results of data related to the clinical pharmacy field | X | |||||
| 4 | PY-4. Uses the knowledge and equipment related to administering medicine to patients and the use of the drug. Gives pharmaceutical care service by providing rational and safe drug use with the duty of observance and supervision. | X | |||||
| 5 | PY-5. Acquires administrative and technical stand-by equipment in the areas where the clinical pharmacy is responsible for and achieves hospital pharmacy practices properly. | X | |||||
| 6 | PY-6. Produces solutions to the problems in the field of clinical pharmacy in the direction of scientific data/ scientific evidence. | X | |||||
| 7 | PY-7. Plans, manages, watches the process, and evaluates activities that oriented improvements of employees as part of a project. | ||||||
| 8 | PY-8. Carries out a study independently by using advanced level knowledge about the field of clinical pharmacy and takes responsibility as a team member in cooperation with other occupational groups working in this field. | ||||||
| 9 | PY-9. Demonstrates embarking on lifelong learning, open for improvement, and continue this behavior. | ||||||
| 10 | PY-10. Follows and evaluates national and international developments in the field of clinical pharmacy. | X | |||||
| 11 | PY-11. Safely documents and keeps track of professional activities and practices. | X | |||||
| 12 | PY-12. Provides information to the patience, healthcare personnel, and society on every drug-related issue. | ||||||
| 13 | PY-13. Informs relevant persons and institutions in the fields of quality assurance of pharmaceutical products | ||||||
| 14 | PY-14. Behaves according to the legislation and professional ethics related to duty, right, and responsibilities as an individual. | ||||||
| 15 | PY-15. Has sufficient consciousness in the field of individual and public health, environmental protection, and job security and applies it. | ||||||
Assessment Methods
| Contribution Level | Absolute Evaluation | |
| Rate of Midterm Exam to Success | 50 | |
| Rate of Final Exam to Success | 50 | |
| Total | 100 | |